Parkinson's Disease Therapeutics Market @

1. Parkinsons Disease Therapeutics Market to 2019 - Pipeline Shows Shift towards Long Term Disease
Management
GBI Research has released the pharma report - “Parkinson’s Disease Therapeutics Market to
2019 - Pipeline Shows Shift towards Long Term Disease Management”. The Parkinson’s
Disease (PD) market is dominated by symptomatic treatments targeting functional impairment in PD.
Levodopa has remained the gold standard treatment for almost 40 years and has significantly improved patient
quality of life. There is currently there is a huge unmet need for disease-modifying treatments that slow
progression or have neuroprotective properties. Over the 2012–2019 forecast period, the PD market is
anticipated to decline from $3.4 billion in 2012 to $2.9 billion in 2019, as a consequence of upcoming patent
expirations of high-profile products such as Azilect, Stalevo and Comtan. Although a few market entrants are
anticipated to enter the market over the forecast period, they are not expected to offset the impact of generic
erosion. Despite their superior profiles over existing treatments, these new products are not expected to
command a premium price as they will be competing against generic products. The current PD pipeline
reflects a shift of focus to long-term PD management, marked by the development of key pipeline candidates
targeting levodopa-associated motor complications. These products will have the potential to change the future
treatment algorithm as side effects of dopaminergic therapies become more manageable.
Scope
A brief introduction to PD, including pathogenesis, disease staging, diagnosis and treatment algorithms
In-depth analysis of the drugs available for the treatment of PD, covering their safety, efficacy, treatment
patterns, and strengths/weaknesses, as well as a heat map comparing drugs in terms of safety and efficacy
Comprehensive review of the pipeline for PD therapies, including individual analysis of a number of late-stage
pipeline drugs that are likely to enter the market in the forecast period, on the basis of phase distribution,
molecule type and molecular target Additional in-depth analysis of pipeline drug clinical trials by Phase,
molecule type, trial size, trial duration, and program failure rate analyses for each molecule type and
mechanism of action Multi-scenario market forecast data to 2019, taking into account how it will be affected
by the introduction of new drugs, the expiry of key patents on current drugs, and changes in disease
epidemiology across the key developed markets of the US, Canada, Japan, Germany, the UK, France, Italy
and Spain Discussion of the drivers of and barriers to market growth Discussion of the licensing and
co-development deals landscape in PD, by stage of development, molecule type and mechanism of action, as
well as analysis both licensing and co-development deals by year, and network maps of licensing and
co-development deals
Reasons to Buy
Understand the different levels of PD therapy from early-stage to advanced Understand the vast scope of the
pipeline, including which molecule types and mechanisms of action are prominent Observe the trends in
clinical trial duration and size amongst clinical phases and molecule types, and use the clinical trial failure rate
analysis to assess the risk profiles of current and/or future developmental programs for PD therapeutics
Observe the trends in clinical trial duration and size amongst clinical Phases, between molecule types and
mechanisms of action, and use the clinical trial failure rate analysis to assess the risk profiles of current and/or
future developmental programs for PD therapeutics Assess the potential clinical and commercial impact of
current late-stage pipeline molecules on the PD therapeutics market
Parkinsons Disease Therapeutics Market to 2019 - Pipeline Shows Shift towards Long Term Disease Management

2. table Of Contents
1 Table Of Contents 1
1.1 List Of Tables 3
1.2 List Of Figures 4
2 Executive Summary 5
2.1 Impact Of Patent Expiration Unlikely To Be Diminished By New Market Entrants 5
2.2 Shifting Focus Of Pipeline To Long-term Management Of Parkinson’s Disease 5
2.3 High Number Of Neuroprotective Targets In Early Pipeline 5
3 Introduction 6
3.1 Overview 6
3.2 Epidemiology 6
3.3 Etiology 7
3.3.1 Loss Of Dopaminergic Neurons 7
3.3.2 Genetic Factors 7
3.3.3 Exposure To Environmental Toxins 7
3.4 Pathophysiology 8
3.4.1 Pathophysiological Changes In Basal Ganglia In Parkinson’s Disease 10
3.4.2 Pathophysiological Changes Involved In The Rise Of Motor Complications In Parkinson’s
Disease 10
3.5 Symptoms 11
3.6 Co-morbidities And Complications 12
3.7 Diagnosis 12
3.7.1 Classification 13
3.8 Prognosis And Disease Staging 16
3.9 Treatment Options 17
3.9.1 Pharmacological Treatment 17
3.9.2 Non-pharmacological Treatments 19
3.9.3 Treatment Algorithm 20
3.10 Gbi Research Report Guidance 24
4 Marketed Products 25
4.1 Therapeutic Landscape 26
4.1.1 Dopamine Replacement Therapies 26
4.1.2 Mao-b Inhibitors 30
4.1.3 Dopamine Agonists 32
4.1.4 Comt Inhibitors 42
Parkinsons Disease Therapeutics Market to 2019 - Pipeline Shows Shift towards Long Term Disease Management

3. 4.1.5 Nouriast (istradefylline) – Kyowa Hakko Kirin 44
4.1.6 Exelon (rivastigmine Tartrate) – Novartis Ag 44
4.1.7 Symmetrel (amantadine Hydrochloride) – Alliance Pharma Plc 46
4.1.8 Other Drugs Targeting Non-motor Symptoms Of Pd 47
4.2 Comparative Efficacy And Safety 48
4.3 Unmet Need 52
5 Pipeline For Parkinson’s Disease 53
5.1 Overall Pipeline 53
5.2 Molecular Targets In Parkinson’s Disease Pipeline 55
5.3 Clinical Trials 58
5.3.1 Failure Rate Of Developmental Pipeline 58
5.3.2 Clinical Trial Sizes 61
5.3.3 Clinical Trial Duration 62
5.3.4 Summary Of Clinical Trial Cost And Risk Analyses 64
5.4 Promising Candidates In Pipeline 65
5.4.1 Rytary (carbidopa, Levodopa) – Impax Laboratories, Inc. 65
5.4.2 Safinamide – Newron Pharmaceuticals S.p.a 65
5.4.3 Pimavanserin – Acadia Pharmaceuticals Inc. 66
5.4.4 Tozadenant – Biotie Therapies 67
5.4.5 Mavoglurant – Novartis Ag 67
5.4.6 Dipraglurant – Addex Therapeutics 68
5.5 Heat Map Of Safety And Efficacy For Parkinson’s Disease Pipeline And Marketed Products 69
6 Market Forecast To 2019 73
6.1 Geographical Markets 73
6.1.1 Global Market 74
6.1.2 North America 76
6.1.3 Top Five Countries Of Europe 79
6.1.4 Japan 82
6.2 Drivers And Barriers 85
6.2.1 Drivers 85
6.2.2 Barriers 86
7 Deals And Strategic Consolidations 88
7.1 Major Co-development Deals 88
7.1.1 Newron Pharmaceuticals S.p.a. Enter Agreement With Zambon Company S.p.a. 91
7.1.2 Qr Pharma, Inc. Enter Research Agreement With Massachusetts General Hospital 91
7.1.3 Ceregene, Inc. Enter Agreement With Genzyme Corporation 91
7.2 Major Licensing Deals 91
Parkinsons Disease Therapeutics Market to 2019 - Pipeline Shows Shift towards Long Term Disease Management

4. 7.2.1 Biotie Therapies Corp. Enter Worldwide Agreement With Ucb Group 94
7.2.2 Ono Pharmaceutical Co., Ltd. Enter Agreement With Bial - Portela & Ca, S.a 94
7.2.3 Domain Therapeutics S.a. Enter Agreement With Prexton Therapeutics 95
7.2.4 Newron Pharmaceuticals S.p.a. Enter Agreement With Zambon Company S.p.a. 95
7.2.5 Oncodesign Sa Enter Agreement With Ipsen S.a. 95
7.2.6 Cephalon, Inc. Enter Licensing Agreement With Mesoblast Limited 95
7.2.7 Shire Pharmaceutical Group Plc Enter Agreement With Heptares Therapeutics Ltd. 96
8 Appendix 97
8.1 All Pipeline Products, By Phase 97
8.2 Sources 114
8.3 Market Definition 123
8.4 Abbreviations 123
8.5 Research Methodology 125
8.5.1 Coverage 125
8.5.2 Secondary Research 125
8.6 Therapeutic Landscape 125
8.7 Epidemiology-based Forecasting 126
8.8 Market Size By Geography 126
8.9 Geographical Landscape 127
8.10 Pipeline Analysis 127
8.11 Competitive Landscape 128
8.11.1 Expert Panel Validation 128
8.12 Contact Us 128
8.13 Disclaimer 128
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Parkinsons Disease Therapeutics Market to 2019 - Pipeline Shows Shift towards Long Term Disease Management

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Parkinsons Disease Therapeutics Market to 2019 - Pipeline Shows Shift towards Long Term Disease Management