How to use the software found here: http://bit.ly/2t9hX7D

1. How to use "Interactive comparison
of false discovery rates and local
false discovery rates" (Bickel, 2019)
David R. Bickel
University of Ottawa
June 23, 2020
http://bit.ly/2t9hX7DLink to the software:

2. Instructions
1. Install Mathematica or the free Wolfram CDF Player
• Wolfram CDF Player: http://bit.ly/2vAF9w4
2. Open the "*.cdf" files from http://bit.ly/2t9hX7D
3. Interpret what you see according to the next slides
4. Play with the sliding controls to explore how the false
discovery rate (FDR) differs from the local FDR
5. Answer Exercise CFDR3 on p. 80 of this book:
• https://davidbickel.com/genomics/

3. FDR = mean(local FDR)
Bickel (2019) "Interactive comparison of false
discovery rates and local false discovery rates"
http://bit.ly/2t9hX7D
mean local FDR highest local FDR of the discoveries
local FDRs of the discoveries# discoveries

4. FDR = mean(local FDR)
(The abbreviations are defined in the previous slide.)
Simple explanation of the concepts:
Chapter 6 of https://davidbickel.com/genomics/

5. FDR = mean(local FDR)

6. FDR = mean(local FDR)

7. local FDRs of the discoveries
highest local FDR of the discoveries
The average of the 10 local FDRs is 0.2,
but only 6 of them are less than 0.2.

8. (The abbreviations are
defined in the previous slide.)
Simple explanation:
Chapter 6 of https://
davidbickel.com/genomics/