Deepak Kumar

assignment genome organisation gene sequencing methods importance of si rna and microrna polymorphism affecting drug metabolism genetic variation and its role in health pharmacol gene mapping and cloning of disease gene anti vivo anti cancer in vitro anticancer agent assignment on preclinical and clinical screening o and other possible animal alternative models in vitro preclinical screening of new substances for the ph assignment on limitation of animal experimentation assignment on alternatives to animal screening met clinical applications and recent advances in gene applications of recombinant dna technology. gene t various types of vectors assignment on recombinant dna technology and gene objectives and preparation. immunoassay for digoxi protocol outline heterogeneous and homogenous immunoassay systems. assignment on general principles of immunoassay: t janus kinase (jak)/signal transducer and activator mitogen-activated protein kinase (mapk) signaling and diacylglycerol. detailed study of following in no (ip3) 5- trisphosphate 4 inositol 1 calcium ion cyclic gmp secondary messengers: cyclic amp intrinsic and extrinsic pathways of apoptosis. nec regulators cell cycles and its regulation. cell death– events immunotherapeutics in clinical practice humanisation antibody therapy types of immunotherapeutics immunotherapy tyrosine kinase receptors and nuclear receptors. gprotein coupled receptors intercellular and intracellular signaling pathways receptors intracellular signaling pathways types of intercellular signaling pathways intercellular signaling pathways steps in cell signaling need of cell signaling saturation kinetics importance and applications of toxicokinetics- toxicokinetic evaluation in precli clinical study report clinical trial monitoring-sa case report forms investigator brochure preparation of protocol contract research organization and its management sponsor study coordinator roles and responsibilities of clinical trial perso cross sectional case control observation study: cohort experimental study- rct and non rct teratogenecity studies (segment ii) female reproductive studies (segment i and segment male reproductive toxicity studies reproductive toxicology studies in vivo chromosomal aberrations studies in vitro chromosomal aberrations studies in vivo micronucleus in vitro micronucleus ames test genotoxicity studies mechanism of mutation icmr ethical guidelines for biomedical research and hum (ich-gcp) guidelines ethical committee- institutio origin and principles of international conference epa and schedule y oecd principles of good laborat ich regulatory guidelines for conducting toxicity stud regulatory and descriptive) mechanistic basic definition and types of toxicology (general statistical methods for evaluating medication safe vigiflow aris g pharmacovigilance targeted clinical investigations and vaccine safet comparative observational studies passive and active surveillance international classification of diseases international non-proprietary names for drugs roles and responsibilities in pharmacovigilance industry and national programmes related to pharma establishing pharmacovigilance centres in hospital evaluation of medication safety who and regulatory terminologies of adr who international drug monitoring programme pharmacovigilance in india and international aspec significance of safety monitoring history and progress of pharmacovigilance