Evolving over Time: The Story of Immune Attack Version 2.0

1. Immune Attack Evolving over Time: The Story of Immune Attack Version 2.0 Michelle Roper & Adam Burrowbridge Federation of American Scientists www.fas.org/immuneattack

5. How do you turn this:

6. And this:

7. And this…

8. Into a Game?

10. … and Fiction The storyline sets up the fiction that we are on a grave mission to save a patient with an immune system that is present, but not yet functional. Our objective is to retrain the immune cells of the innate system to fend off invading pathogens.

11. Immune Attack: The Vision Characters Powers of the Character level Macrophage Battleship : big, lethal, slow, not terribly smart. 1 Neutrophil Swift boat: moves quickly and in large numbers 2 Dendritic Intelligence agents: detect intruders and bring evidence (typically body parts of the intruder) to processing centers (lymph nodes 3 T (CD-8) Specialized Hit men: lethal to cells harboring attacking agents (e.g. kills cells infected with a virus) 3 T (CD-4 T H 2) Intelligence Operations Manager: Interrogates intelligence agents and if satisfied that they bring valid news of an attack, provide a key that can unlock chemical agents. 4 B Chemical Warfare Operations: very high tech weapon system. Each specialized to produce highly specialized chemicals targeting specific invaders 4 T (CD-4 T H 1) Emergency Support Team: pressed into action when macrophages are too dumb to do their job 5 Natural Killer (NK) Night Watch men 6 Mast Cells Mines: explode releasing histamine when hostile action is detected 7

12. Version 2.0 Changes from v1.0 to v2.0 Lessons Learned Blood Vessel Network Visualizations of environment must reinforce key concepts Connective Tissue Remodel The importance of realism Trophy Room Method of tracking game progress & in-game assessment Scoring Gameplay vs. Learning Objective Scoring Options Making the game accessible for all levels of gameplayers Save/Load Instructor Menu Advisors Adding personality to immunology Q&A My Learning Assistant evolution Game Progress Teachers: “What do I have to show for it” Gameplay Scale, visualizations, conceptualization, knowledge transfer Briefing Interstitials Importance of supporting multiple concepts

13. Blood Vessel Network Changes from v1.0 to v2.0 Blood Vessel Network Connective Tissue Remodel Trophy Room Scoring Options Save/Load Advisors Q&A Implementation Hurdles Game Progress Gameplay Briefing Interstitials

14. Connective Tissue Remodel ? Changes from v1.0 to v2.0 Blood Vessel Network Connective Tissue Remodel Trophy Room Scoring Options Save/Load Advisors Q&A Implementation Hurdles Game Progress Gameplay Briefing Interstitials

15. Connective Tissue Remodel Changes from v1.0 to v2.0 Blood Vessel Network Connective Tissue Remodel Trophy Room Scoring Options Save/Load Advisors Q&A Implementation Hurdles Game Progress Gameplay Briefing Interstitials

16. Connective Tissue Remodel Changes from v1.0 to v2.0 Blood Vessel Network Connective Tissue Remodel Trophy Room Scoring Options Save/Load Advisors Q&A Implementation Hurdles Game Progress Gameplay Briefing Interstitials

22. Question & Answering Alphabetized Glossary Answers Changes from v1.0 to v2.0 Blood Vessel Network Connective Tissue Remodel Trophy Room Scoring Options Save/Load Advisors Q&A Implementation Hurdles Game Progress Gameplay Briefing Interstitials

24. Gameplay

27. Briefing Interstitials Changes from v1.0 to v2.0 Blood Vessel Network Connective Tissue Remodel Trophy Room Scoring Options Save/Load Advisors Q&A Implementation Hurdles Game Progress Gameplay Briefing Interstitials