The aim of the presentation was to create awareness about the interaction between health and travel. Here, particular emphasis is on infectious diseases. Read and digest. Comments are welcomed.
Presentation bumpsa 2015-symposium - effect of global travel on health _ the case of infectious diseases
1. EFFECT OF GLOBAL TRAVEL ON HEALTH:
the case of infectious diseases
By
NCHANJI GORDON T.
BUMPSA 2015
2. OUTLINE
Introduction
Conceptual Framework
Why travel?
Infectious diseases and travel
CASES: TYPHOID MARY: CHOLERA:
MALARIA: SARS; EBOLA
How is this issue handled?
CONCLUSIONS
2
3. INTRODUCTION
Today, there is growing recognition that an outbreak anywhere can
potentially represent an emergency of international public health concern.
“The movement of populations shapes the patterns and distribution of
infectious diseases globally” (Wilson, 2003).
During travel, humans carry their genetic makeup, immunologic sequelae of
past infections, cultural preferences, customs, and behavioral patterns
(Wilson, 1995).
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5. GLOBAL TRAVEL
Geographical location
Route of Transmission
- Foodborne and waterborne diseases
- Vector-borne diseases
- Zoonoses (diseases transmitted by animals)
- Sexually transmitted diseases
- Blood borne diseases
- Airborne diseases
- Diseases transmitted via soil / formites
Economic Tourism Social
NON-INFECTIOUS
DISEASES
-NCDs/Genetics
-Toxins (chemical and
biological))
INFECTIOUS DISEASES
-Virus
-Bacteria
-Fungi
-Protozoa
How do we handle this problem?
-Sensitization
-Prevention
-Vaccination
-Quarantine
ConflictsNatural Disasters
Figure 1: Conceptual flow of ideas (with inspiration from WHO’s International Travel and Health guide, 2012 )
ENVIRONMENTAL
RISKS
-Altitude
-Heat/humidity
-UV radiation
INJURY AND VIOLENCE
-Road traffic injuries
-Recreational waters
-Interpersonal violence
PSYCHOLOGICAL
HEALTH
Stress
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6. Why do we travel?
Social
Natural disasters
Conflicts
Figure 2: Tourism and commerce: cornerstones for “A World of
Movement.”
Figure 3: Tourism is the fastest growing industry worldwide,
and the number of in-country arrivals is projected to double
by the year 2020 (Source: Hurley and Friend, 2006)
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8. Selected pecific infectious diseases involving potential
health risks for travellers(WHO, 2007)
Disease Agent Risk
ANTHRAX Bacillus anthracis Very low for most travellers.
BRUCELLOSIS Brucella bacteria Generally low, but higher in rural/agricultural areas
LISTERIOSIS Listeria monocytogenes Low. consumption of unpasteurized milk and
milk products and prepared meat products
VIRUSES
Chikungunya Chikungunya virus Risk in endemic areas/those affected by epidemics
Yellow fever virus Yellow fever virus Risk in endemic area; greater for visitors who enter forest and jungle areas
DENGUE Dengue virus Significant risk in endemic areas/those affected by epidemics
PROTOZOA
GIARDIASIS Giardia intestinalis Significant risk in recreational waters
Parasitic
LEISHMANIASIS Leishmania sp Visitors to rural and forested areas in endemic countries are at risk.
TRYPANOSOMIASIS Trypanosoma brucei sp Risk in endemic regions if they visit rural areas for hunting,
fishing, safari trips, sailing or other activities in endemic areas.
Risk varies geographically
and with lifestyle (Toovey
et al., 2007a)
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9. Routes of transmission
Figure 4: Common routes for potential transmission of infectious diseases
between animals and humans and vice versa (Hurley and Friend, 2006).
Waterborne diseases
Sexually transmitted diseases
Bloodborne diseases
Diseases transmitted via soil
• MRSA lives for a week on seat-back
pockets in Airplanes; E. coli O157:H7
persisted for 96 hours on armrests and
72 hours on tray tables (ASM, 2014).
• Windshield washer fluid as potential
source of Legionella pneumophila; 84%
of samples at a high concentration of
8.1×104 CFU/mL (Schwake, 2015).
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11. Typhoid Mary: Mary Mallon~
Cook: 1900-1907
Asymptomatic carrier of typhoid fever
The work of a chronic typhoid germ
distributor (SOPER, 1907).
First quarantine (1907–10); Mary Brown
Release and second quarantine (1915–38)
Death 1938 (68 years)
Blamed for 51 Cases and 3 Deaths
(The New York Times, 1938).http://upload.wikimedia.org/wikipedia/
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12. CHOLERA: Haiti 2010
-START: October 21, 2010
-Nov. 16: + cases in the
neighboring Dominican
Republic and in Florida.
-Nov. 19: had reached
every department of the
country
-Several confirmed
cases in the Dominican
Republic (3) and all
confirmed U.S. cases (5)
were among travelers
from Haiti (CDC, 2010).
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13. Malaria
Population movement
contributes to the spread of
malaria (Martens and Hall,
2000)
Risk is dependent upon the
entomological inoculation
rate faced by the long-term
traveler.
Risk is cumulative, increasing
with duration of exposure,
greatest in rural and periurban
areas, and least in urban
centers (Toovey et al., 2007b).
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14. SARS
(Source: Hurley and Friend, 2006)
-February 2003, a Canadian and a US
resident were both infected when they and
the index SARS patient stayed at the same
hotel in Hong Kong
--The US (symptomatic) resident returned
as a suspect case; was treated with caution;
so, she did not cause a SARS outbreak.
--The Canadian resident returned to Canada
as an asymptomatic case and caused a
SARS outbreak in Toronto (Ruin et al.,
2003).
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17. Global Outbreak Alert and Response Network-(GOARN)
-Creation: April 2000. W.H.O
-Presently monitoring:
Middle East respiratory syndrome coronavirus (MERS-CoV) -United Arab
Emirates, Qatar, Saudi Arabia, Korea, Germany and The Philippines: 1118
laboratory-confirmed cases of infection with MERS-CoV, including at least 423
related deaths
Meningococcal disease -Niger: 6,179 suspected cases of meningococcal
meningitis, including 423 deaths (WHO, 2015).
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20. Prevention/control of spread
The most effective measure and needs to be prompt
Hygiene (Faecal-Orally Transmitted Diseases)
Prophylaxis (Malaria)
Cure all disease humans and/animals
Quarantine (Ebola, Swine and bird flu,)
Vaccination (Yellow fever, Polio,)
Due to better hygienic standards at
travel destination, Faeco-orally
transmitted diseases among travellers
is decreasing (Baaten et al., 2010)
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21. CONCLUSIONS
Travel is very much linked to infectious diseases???
Knowledge of transmission routes and putting in place of proper
disinfection protocols, and personal hygiene is invaluable to keeping
travelers safe.
Rapid response in case of outbreaks, to establish source and
transmission mechanism(s), so as to prevent spread and thus control
the disease.
Are we doing enough? (Ebola outbreak 2014).
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Outbreaks threaten the health of the world’s population
The consequences of travel extend beyond the traveler to the population visited and the ecosystem.
Microbes, animals, and other biologic life also accompany them.
STDs:::Several aspects of travel such as opportunity, isolation, and the desire for unique experiences
all enhance the likelihood of casual sexual experiences while abroad.
Injuries also occur in other settings,
particularly in recreational waters in association with swimming, diving, sailing and other activities.
Under the stress of travel, pre-existing mental disorders can be exacerbated. Disorders include: Anxiety disorders
Mood disorders and suicide attempts
Psychotic disorders
Disorders due to psychoactive substance use
TRAVEL: to make a journey, usually over a long distance
Over 880 million tourists in 2009
Nowadays, there are 29.6 million scheduled flights per year and around 2.7 billion passengers are transported
Annually (Huang et al., 2012).
Travel medicine is the medical subspecialty which promotes healthy and safe travel.
Criteria for selecting these diseases:
— diseases that have a sufficiently high global or regional prevalence to constitute a significant risk for travellers;
— diseases that are severe and life-threatening, even though the risk of exposure
may be low for most travellers;
— diseases for which the perceived risk may be much greater than the real
risk, and which may therefore cause anxiety to travellers;
— diseases that involve a public health risk due to transmission of infection
to others by the infected traveller.
Leptospirosis and rickettsiosis – the most common travel-associated bacterial zoonoses (Leshem et al., 2011)
-In October 2010, cholera appeared in Haiti for the first time in nearly a century.
-caused by bacteria introduced into Haiti as a result of human activity; more specifically by the contamination of the Meye Tributary System of the Artibonite River with a pathogenic strain of the current South Asian type Vibrio cholerae.
Ongoing cholera outbreak in Burundian refugees ( As of 2 June 2015, a total of 4578 suspected cholera cases) puts local Tanzanian populations at risk.
The sudden influx of people, combined with overcrowding and poor sanitation, intensified the
transmission of the ongoing cholera outbreak.
Therefore, travel by the exposed and infective individuals is one of the main channels to spread the disease, and travel by the undiagnosed asymptomatic individuals is potentially more harmful than that
of the infectives.
On 23 March 2014 WHO’s African Regional Office reported an outbreak of Ebola virus disease in Guinea.
S. korea: 108 confirmed cases: 9 deaths: 3400+ quarantined: around 2400 schools closed
Yellow fever vaccination is recommended for all travellers ≥9 months old in areas where there is evidence of persistent or periodic yellow fever virus transmission.