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INTRODUCED 1st
TIME IN INDIA
NUTAS
BREAST CONSERVANCY THERAPY CENTRE
A JOINT VENTURE BETWEEN
INCREDIBLE GROUP ( INDIA )
&
S.C.T.D.Co. Ltd. ( CHINA )
AWARENESS ON BREAST CANCER
BREAST CANCER IS CURABLE NOW WITH PREVENTIVE
MEASURES AND BREAST SELF EXAMINATION
EARLY DETECTION ALONE CAN SAVE LIVES
A FIGHT AGAINST BREAST CANCER, No.1 KILLER DISEASE
AMONG WOMEN
BECAUSE IT MATTERS TO OUR DEAR WOMEN
WOMEN ARE THE BACKBONE OF EVERY FAMILY
NO HOUSE IS COMPLETE WITHOUT
A WOMAN IN A FAMILY
BREAST HEALTH & THE FUTURE OF BREAST CANCER
IS IN WOMAN’s HANDS ONLY
NO WOMEN IS IMMUMUNE TO
GRAND MOTHER
DAUGHTER COUSIN
MOTHER FRIEND
WIFE AUNT
NIECE SISTER
GRAND DAUGHTER
DOCTORS WANTS TO FIND THE CURE FOR THE BREAST CANCER &
FOR BREAST CONSERVANCY TO SAVE A WOMAN’s MOST
PRECIOUS ORGAN THE BREAST
MY PATIENTS ARE WAITING FOR THE SAME ?
HELLO DOCTOR WAIT NOW WE HAVE AN ANSWER
FOR 100% BREAST CONSERVANCY
NUTAS
A NON INVASIVE ULTRASOUND TUMOR ABLATION SYSTEM
TO ABLATE TUMOR WITH COAGULATIVE NECROSIS
WITH EFFECTIVE RATE AS 98.4%
THERE WILL BE IMMEDIATE FREEDOM FROM THE
CANCEROUS CELLS PRESENT IN THE TUMOR
NOW
WOMEN CAN SAY NO TO LUMPECTOMY / RADICAL MASTECTOMY
A Gift of Beauty and Hope
NUTAS
IT IS A VICTORY OVER SURGERY & CANCER TREATMENT
A CUTTING EDGE TECHNOLGY TO TREAT VARIOUS SOLID TUMORS
BREAST CANCER IS CONQUERABLE IF DETECTED IN EARLY STAGES & TREATED
WITH NUTAS ALONE OR
IN COMBINATION WITH CHEMO / RADIO / HORMONE / D.C.THERAPIES, etc.
IT IS A BOON FOR SURGEONS, PATIENTS & GOVT. CANCER HOSPITALS
IT IS AN INNOVATION IN THE FIELD OF RADIOLOGY
IT CAN TREAT CANCEROUS TUMOR IN BREAST IN 0-1 STAGES WITHOUT
SURGERY PLUS IT CAN BE USED IN OTHER STAGES ALONG WITH MULTI
MODALITIES TREATMENT OF CHEMO/ RADIO THERAPIES, FOR COMPLETE CURE
NUTAS
Breast Conservancy Therapy Centre
It was set up in Delhi in April, 2014 and it was inaugurated by
the present D.G.H.S., Govt. of India, New Delhi
Dr. Jagdish Prasad
It is a research product and has 9 Patents regd. in China
BREAST CANCER
IT IS No. 1 KILLER DISEASE AMOMG WOMEN IN THE WORLD & INDIA IS NOT FAR BEHIND
AS THERE WERE 155,367 NEW BREAST CANCER PATIENTS IN THE YEAR 2014
THE SAID FIGURE WILL INCREASE TO 200,000 BY THE YEAR 2020
1 IN 25 PER LAC INDIAN WOMEN ARE AT RISK OF ACQUIRING BREAST CANCER DURING
THEIR LIFETIME & IS AN ALARMING SITUATION TO TREAT & CURE
WE CAN SAVE WOMEN LIVES WITH EARLY DETECTION ALONE
WOMEN MUST TAKE OF THEIR BREAST HEALTH WITH REGULAR BREAST SELF
EXAMINATION, HEALTHY DIET, EXCERCISES & PREVENTIVE MEASURES
KINDLY VISIT VARIOUS YOUTUBE VIDEOS ON BREAST ANATOMY, B.S.E., BREAST CANCER
SYMPTOMS & CONVENTIONAL TREATMENT AVAILABLE TO TREAT BREAST CANCER:
https://www.youtube.com/watch?v=L7xjiqGwhW4
https://www.Youtube.com/watch?v=VsviAPGfPUo
https://www.youtube.com/watch?v=ga_mHYGgeFM
https://www.youtube.com/watch?v=NQvjngIFIiA
NOW WOMEN MAY NOT REQUIRED TO UNDERGO CONVENTIONAL TREATMENT OF
SURGERY TO TREAT CANNCEROUS TUMOR IN BREAST
NOW WOMEN HAVE A CHOICE WITH A NON INVASIVE TREATMENT TO TREAT TUMOR
NUTAS
IT IS AN ALTERNATIVE FOR SURGERY & TO SAVE THEIR BREAST FROM LUMPECTOMY
/ MASTECTOMY WITH IMMEDIATE FREEDOM FROM CANCER CELLS PRESENT IN THE
TUMOR WHICH WILL REDUCE THE METASTASIS RATE AS WELL FOLLOWED BY CHEMO ,
RADIO,HORMONE THERAPIES FOR COMPLETE CURE
IT IS INCISION LESS, NO BLEEDING, NO GENERAL ANESTHESIA, NO HOSPITALIZATION
IT IS RADIATION FREE ENERGY TO ABLATE TUMOR WITH IRREVERSIBLE COAGULATIVE
NECROSIS WITHOUT ANY HARM TO THE SURROUNDING HEALTHY TISSUES OR SIDE
EFFECTS AND IS 100% BREAST CONSERVANCY THERAPY TO TREAT WITH
KINDLY VISIT YOUTUBE VIDEOS FOR DETAILED INFORMATION ON NUTAS SYSTEM :
http://www.youtube.com/watch?v=6Dpl1ZNI4XQ
https://www.youtube.com/watch?v=FibOgIH6dfw
https://www.youtube.com/watch?v=xLPTeB_W_g4
I. Principle of NUTAS
• Under the guidance of Color Doppler Ultrasound images, NUTAS focuses
high intensity ultrasound beams generated in vitro on target lesions
inside body. High energy deposition appears in the focal area which
destroys tumor cell structure, and results in irreversible coagulative
necrosis of tumor tissues.
NUTAS treatment applies to
the target regions which
ultrasound can detect,
with good & enough
ultrasound path.
• According to the size, shape and boundary of tumor, NUTAS automatically generates treatment
scheme by using tumor tomography recognition and 3D reconstruction technologies. Then, by
controlling the movement of focused ultrasound, it cover the whole tumor, the complete tumor
ablation is accomplished.
• The temperature of the focal volume of an Ultrasound Beam is rapidly raised to cytotoxic levels
to selectively ablate a targeted tumor at depth cell-by-cell & line-by-line layers of cancerous
cells present in the tumor to ablate, without any damage to the surrounding or overlying
healthy tissues.
•
Coagulative necrosis is a type of accidental cell death typically caused by ischemia or infarction.
In coagulative necrosis the architecture of dead tissue is preserved for at least a couple of
days.[1]
It is believed that the injury denatures structural proteins as well as lysosomal enzymes
thus blocking the proteolysis of the damaged cells. The lack of lysosomal enzymes allows it to
maintain a "coagulated" morphology for some time. Like most types of necrosis if enough viable
cells are present around the affected area regeneration will usually occur.
• Coagulative necrosis can also be induced by high local temperature; it is a desired effect of
treatments such as high intensity focused ultrasound applied to cancerous cells.
Indications
• Breast Tumors: Benign / Malignant, Suggest choosing indications and
perform comprehensive treatment;
• Liver Tumors: Benign and malignant liver tumors. The tumor which is
blocked by rib can be treated by ablating rib or other method to improve
the ultrasound path;
• Bone Tumors: Original and metastatic tumors except skull and spine;
• Pancreatic Tumors: Non-icteric pancreatic tumors or pancreatic tumors
which have received jaundice reducing treatment;
• Kidney Tumors: Benign and malignant kidney tumors except those with
renal vein tumor emboli or inferior vena cava tumor emboli. The tumor
which is blocked by rib can be treated by ablating rib or other method to
improve the ultrasound path;
• Soft Tissue Tumors: Benign or malignant tumors in soft tissue;
• Uterine Fibroid;
• Benign Prostatic Hyperplasia and Prostatic Cancer;
• Retroperitoneal, abdominal and pelvic solid tumors with good
ultrasound path.
Contraindications
• Tumors in gassy and hollow viscera;
• Tumors in the central nervous system;
• Skin with ulcers or infections in the treated region;
• Skin in the treated region that has been treated by radiotherapy over
45Gy;
• Tumor thrombi in the vena cava system in the path of an ultrasound
wave;
• Apparent calcification on an arterial vessel wall in the path of an
ultrasound wave;
• Patients with major organ failure;
• Patients with severe coagulation disorders or definite bleeding
tendency;
• Patients with major organ failure or whose life cycle is estimated to be
within 3 months;
• Tumors are not clearly visible in the matched localization image system.
A Gift of Beauty and Hope
FOR 100% BREAST CONSERVANCY
BREAST HEALTH
BREAST IS AN ELIXIR OF LIFE TO ENJOY THE BLISSFUL LIFE OF MARRIAGE
BREAST MILK IS A LIQUID GOLD & THE ULTIMATE ELIXIR FOR HUMAN LIFE,
WOMANHOOD & MOTHERHOOD TO ENJOY THIS BEAUTIFUL WORLD
MEN CAN TAKE CARE OF THEIR WIFE BETTER WITH REGULAR B.S.E.
DURING....
SO THAT IT REMAINS IN PINK OF HEALTH & FOR SELFISH MOTIVE
WOMEN DO FORGET TO TAKE CARE OF THEMSELVES BUT RARELY FORGET TO
TAKE PROPER CARE OF OTHERS IN THE FAMILY
Who are we?
• We have set up a medical centre in Delhi under the name and style
NUTAS, Breast Conservancy Therapy Centre in April,2014.
• It is an innovation in the field of Radiology to treat various solid tumor (
Benign / Malign ) without Surgery & Radiation to ablate tumor in Breast.
• Trials on other solid tumors i.e. in Liver, Kidney, Pancreatic & in Pelvic
Area are under process.
• NUTAS - is a Non Invasive High Intensity Focused Ultrasound Ablation
System and it is based on a trusted scientific technology called HIFU
Therapy
• Mr. Ashok Arora is a CEO of M/s Incredible Group who has experience
in Medical field since 1975
• Mr. Ashok Arora is HIFU Technical Specialist, Entrepreneur and had a
vision to enter into a Joint Venture with a Chinese Co. M/s
S.C.T.D.Co.Ltd. in Shenyang in the year 2008 to develop an innovative
system called NUTAS E-10 a Non Surgical medical device to treat Breast
Cancerous tumor without Surgery to ablate a tumor with coagulative
necrosis.
What is our product / service?
• It is the 1st
medical centre in India to treat Breast Cancer patient without surgery
& radiation to ablate a tumor and is a replacement for surgery followed by
Chemo / Radiotherapy / Hormone / D. C. Therapies, etc. for complete cure.
• This is the only referral centre in India at the moment to treat and to market the
equipment all over India , South East Asia and in Middle East Countries as well.
The equipment is being manufactured in China since the year 2000 but after a
long research on the same the CE approval of the same was granted in October,
2012 to market the same to treat solid tumors in breast only Benign / Malignant )
• NUTAS is Referral Centre and is a Joint Venture between Incredible Group, Delhi
and M/s S.C.T.D.Co. Ltd. of China and we have treated more than 138 breast
Cancer patients with success from May,2014 to February,2016 . It was
inaugurated by the present D.G.H.S., Dr. Jagdish Prasad.
• World is moving from open surgery to Breast conservancy & NUTAS is 100%
Breast Conservancy
Breast Cancer – The Current
Scenario• In India more than 155,000 women new patients were diagnosed to be suffering
from Breast Cancer in the year 2014, out of 11 lacs New Cancer patients and this
no. will increase to 200,000 by the year 2020 as per WHO report.
– India recorded 70,218 deaths from Breast cancer in 2013
– In India (1 in 25 ) Women are at risk and may be diagnosed to be suffering
from Breast Cancer in their lifetime and (1 in 10 ) young Indian women are at
risk to be diagnosed to be suffering from Fibroadenoma in Breast ( Benign
Tumor )
– NUTAS can treat both Benign / Malignant tumors in an OPD under local
anesthesia to ablate a tumor irrespective of its size with irreversible
coagulative necrosis ( Tissue death of cancer cells present in the tumor)
– In Delhi / NCR on an average 10,000 cases of breast cancer surgeries are
being carried out in a year in more than 25 dedicated Cancer hospitals in
Delhi / NCR
• Surgery is the only choice to treat Breast Cancer patients in any stage for
treatment along with Chemo / Radio / Hormone therapy, etc. but with Surgery a
woman is forced to part with her Breast by Lumpectomy / Mastectomy
• The Vision was to replace surgery for Breast cancer patients to save their most
precious organ the breast and NUTAS is the answer for 100% Breast
.
HOW BREAST CANCER
DEVELOPS ?
BREAST CANCER IS A CANCER THAT STARTS IN THE TISSUES OF THE BREAST
AND THERE ARE TWO MAIN TYPES OF BREAST CANCER :
•DUCTAL CARCINOMA STARTS IN THE TUBES OF DUCTS THAT MOVE MILK FROM THE
BREAST TO THE NIPPLE
•MOST BREAST CANCERS ARE OF THIS TYPE
•LOBULAR CARCINOMA STARTS FROM THE PART
OF THE BREAST CALLED THE LOBULES WHICH
PRODUCE MILK
WHAT IS NUTAS ?
It is Non – Invasive Focused Ultrasound Treatment
As a non-invasive method of lumpectomy, focused ultrasound may offer the
following benefits in treating breast cancer:
•No post operative complications and a very short recovery time, compared
with surgical lumpectomy;
•No scar tissue and no risk for breast deformation;
•Zero risk for infection; and
•More precise treatment as a result of real-time guidance by Ultrasound Guided
FUS
With increased precision, focused ultrasound has the potential to be a more
effective lumpectomy than surgery
Thus it could potentially be a primary treatment approach for various patients in
future to be treated initially with HIFU technology and to save a woman’s most
precious organ the breast from Lumpectomy / Mastectomy or any other organs
required to be treated with for a speedy treatment in an OPD and there is no
Surgical removal of tissue involved.
HOW EFFECTIVE IS SURGERY AS A CURE ?
According to Dr. Kapil Kumar a renowned Breast Cancer surgeon
has mentioned on 18th
March, 2016 in an interview to TOI, that
Surgery is most effective in the EARLY stages when the cancer is
in-situ or has not spread and is in non-metastasis stage and it means
that Surgery is not effective in stage II & III and in stage IV it is not
recommended by the surgeons.
Whereas NUTAS treatment is ideal in EARLY stages of 0-I and can be
advised in II,III & IV as well stages being Non–Invasive, as a Palliative
treatment and is the safest treatment to ablate a tumor and will
reduce metastasis rate followed by various modes of treatment
available for complete cure instead of waiting for surgeries.
WHICH TREATMENT IS BETTER SURGERY OR NUTAS
NUTAS -A BOON FOR SURGEONS, PATIENTS & GOVT.EXCHEQUER TO SAVE ON COST OF SURGER-
IES & HOSPITAL BEDS, O.T. EXPENSES, MEDICINES, DISPOSABLES, POST OPERATIVE CARE, etc.
NO INCISION, NO BLEEDING, NO GENERAL ANESTHESIA, NO HOSPITALIZATION, NO BED REST,
NO MEDICINES FOR HEALING, NO SIDE EFFECTS, AN OPD BLOODLESS PROCEDURE, SAFE &
RADIATION FREE ENERGY TO ABLATE TUMOR WITH IRREVERSIBLE COAGULATIVE NECROSIS
SURGEONS -WILL REMOVE THE BENIGN / MALIGNANT TUMOR WHICH WILL DEFORM / REMOVE
THE WHOLE BREAST, THE MOST PRECIOUS ORGAN OF A WOMAN WITH HOSPITALIZATION,
BED REST & MEDICINES TO HEAL THE WOUND & RECONSTRUCTION COST OF BREAST
CHEMOTHERAPIES – IT REQUIRES MINIMUM 3-12 SESSIONS IN AN INTERVAL OF 21-45 DAYS TO
KILL CANCER CELLS PRESENT IN THE TUMOR OR IN THE BODY. CONFIRMATION REQUIRES
SEVERAL TESTS OVER A PERIOD OF YEAR & ABOVE
RADIOTHERAPY – IT REQUIRES MINIMUM 35 SITTINGS IN 5 WEEKS OF CONTINUOUS
RADIATION THERAPY TO KILL THE CANCEROUS CELLS IN TUMOR , etc. CONFIRMATION REQUIRES
SEVERAL TESTS
NUTAS – IT BURNS THE CANCEROUS CELLS PRESENT IN THE TUMOR IN AN HOUR, CELL BY CELL
WITH REAL TIME MONITORING ON SCREEN, IN ONE SITTING WITHOUT ANY SURGICAL KNIVES
WITH IMMEDIATE FREEDOM FROM METASTASIS & CONFIRMED REPORT AFTER 15 DAYS ONLY
ABSTRACT ON NUTAS
IT CAN BE RECOMMENDED SAFELY FOR TREATMENT BY PHYSICIANS / SURGEONS
IT IS RADIATION FREE ENERGY TO ABLATE TUMOR WITH IRREVERSIBLE COAGULATIVE
NECROSIS in ONE SITTING OR IS REPEATABLE
IT HAS NO POST OPERATIVE COMPLCATIONS AS COMPARED TO SURGERY
IT IS HARMLESS FOR SURROUNDING HEALTHY TISSUES
IT WILL BURNT THE CANCER CELLS PRESENT IN THE TUMOR IN ONE SITTING WHICH
WILL REDUCE METASTASIS WITH IMMEDIATE FREEDOM FROM CANCER CELLS PRESENT
IN THE TUMOR WHICH IS THE PRIMARY SOURCE OF SPREAD OF CANCER IN THE BODY
IT CAN BE TREATED SAFELY WITH NUTAS ALONE IN 0-1 STAGES OR IN NON METASTASIS
STAGE OR WITH ADJUVANT THERAPY AS PER THE CLINICAL ADVICE OF ONCOLOGISTS
IT CAN ALSO BE RECOMMEMNDED SAFELY FOR PALLIATIVE TREATMENT IN II – IV
STAGES AS WELL ALONG WITH MULTI MODALITIES OF TREATMENT FOR COMPLETE CURE
NUTAS
TREATMENT PROTOCOL FOR TREATING BREAST CANCER IN VARIOUS STAGES AS PER
THE RECOMMENDATIONS OF THE TUMOR BOARD & ONCOLOGISTS TO TREAT
WE TREAT AGAINST CONFIRMED TRUE CUT / CORE BIOPSY REPORT COMPLETE WITH ER / PR / HER2 nue
STATUS ONLY WITH MULTI MODALITIES OF TREATMENTS AVAILBLE FOR COMPLETE CURE
WITH NUTAS THERAPY WE CAN BURNT / KILL THE CANCER CELLS PRESENT IN THE TUMOR ONLY
IT IS 100% BREAST CONSERVANCY FOR PATIENTS DIAGNOSED WITH BREAST CANCER & WOMEN CAN SAY
BYE-BYE TO LUMPECTOMY / MASTECTOMY
Stage T 0 – T 1 = NUTAS + CHEMO OR NUTAS + HOMEOTHERAPY ( 9 Months Treatment Course to reduce
CA Level ) OR NUTAS + COW URINE THEARPY ( Govt. Approved AUYERVEDIC ) OR NUTAS + D.C . Therapy
Stage T 2 = NUTAS + CHEMO + RADIO OR NUTAS +HOMEO FOR 9 MONTHS / Cow Urine Therapy OR NUTAS +
D.C. Therapy
Stage T 3 = NUTAS + CHEMO + RADIO OR NUTAS + CHEMO + RADIO + HOMEO/ COW URINE THERAPY
OR NUTAS + D.C. Therapy
Stage T 4 = NUTAS + CHEMO + RADIO + HOMEO / COW URINE THERAPY OR NUTAS + D.C. Therapy
NUTAS – It can be used to treat Tumor Benign / Malignant in Breast and the Breast too can be saved as well.
CLINICAL TRIALS ON BREAST CANCER BY HIFU TECHNOLOGY
British Journal of Cancer (2003) 89, 2227–2233. doi:10.1038/sj.bjc.6601411 www.bjcancer.com
Published online 12 December 2003
A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment
of patients with localised breast cancer
1
Institute of Ultrasonic Engineering in Medicine, and Clinical Center for Tumor Therapy of 2nd Hospital, Chongqing
University of Medical Sciences, Box 153, 1 Medical College Road, Chongqing 400016, China
Correspondence: Dr F Wu, E-mail: mfengwu@yahoo.com
Received 24 April 2003; Revised 26 August 2003; Accepted 12 September 2003
Abstract
High-intensity focused ultrasound (HIFU) is a noninvasive treatment that induces complete
coagulative necrosis of a tumour at depth through the intact skin. This study was to explore the
possibility of using HIFU for the treatment of patients with localised breast cancer in a controlled
clinical trial. A total of 48 women with biopsy-proven breast cancer (T1–2
, N0–2
, M0
) were randomised
to the control group in which modified radical mastectomy was performed, and the HIFU group in
which an extracorporeal HIFU ablation of breast cancer was followed by modified radical mastectomy.
Short-term follow-up, pathologic and immunohistochemical stains were performed to assess the
therapeutic effects on tumour and complications of HIFU. The results showed that no severe side
effect was observed in the HIFU-treated patients. Pathologic findings revealed that HIFU-treated
tumour cells underwent complete coagulative necrosis, and tumour vascular vessels were severely
damaged. Immunohistochemical staining showed that no expression of PCNA, MMP-9, and CD44v6
was detected within the treated tumour cells in the HIFU group, indicating that the treated tumour
cells lost the abilities of proliferation, invasion, and metastasis.
It is concluded that, as a noninvasive therapy, HIFU could be effective, safe, and feasible in the
extracorporeal treatment of localised breast cancer.
Keywords:
high-intensity focused ultrasound; focused ultrasound surgery; breast carcinomas; therapy; ablation
TREATMENT PRINCIPLE OF NUTAS :
Under the guidance of Color Doppler Ultrasound images,
NUTAS focuses high intensity ultrasound beams generated in
vitro on target lesions inside the body.
High energy deposition appears in the focal area which destroys
tumor cell structure and results in irreversible coagulative
necrosis of tumor tissues, according to the size, shape and 3D
reconstruction technologies.
Then, by controlling the movement of focused ultrasound the
whole tumor, the complete tumor ablation is accomplished.
PROMISING RESULTS ON BREAST CANCER STUDY WITH HIFU :
Dr. Alessandro Napoli, M.D., Ph.D., assistant professor of radiology at Sapienza
University in Rome, presented the results of his study involving 12 patients with
invasive ductal breast cancer. All patients were treated with FUS, and post-
treatment, histological evaluation confirmed the absence of residual disease in
the treatment area in 10 patients. Though this study is part of early stage research
Dr. Napoli is hopeful that focused ultrasound will one day be a treatment option
for women with Breast cancer
The Doctors at Churchill Hospital in Oxford (Radcliffe Hospitals NHS) where
Professor Sir Peter Morris, President of Royal College of Surgeons say Breast
cancer patient’s lumps could instead be “zapped” with ultrasound, sparing them
the trauma of breast removal.
NUTAS is a Cancer Treatment of 21st
Centaury
Imagine being treated for cancer in an outpatient setting
No Hospital Stay, No Surgery, Non Incision, No Radiation, No Side effects, No
Dysfunctions of Limbs & Organs (Equivalent to Surgery)
It is a One Time Treatment Cost for the patients to go through, avoids the
costly expenses of treatment of Cancer & Reconstruction cost of Breast as it is
a trauma for a women to live without her most precious organ the Breast
It is a Revolutionary Approach for Tumor Treatment with Remote Non –
Invasive Surgery & the only system in the World to treat with NO DELAY to
treat patients diagnosed to be treated
ADVANTAGES OF HIFU / NUTAS THERAPY
•HIFU is Radiation free energy which kills the cancer cells by focused High
Intensity Ultrasounds in the solid tumor to treat which will burn the cancer
cells present in the tumor only without affecting the surrounding healthy
tissues & the tumor residue after treatment with NUTAS will be autolysed by
Phagocytes as it happens in Radiotherapy & RFA irrespective of tumor size to
treat with
•HIFU treatment has no side effects or any damaging side effects than
conventional treatment with surgical procedure
•HIFU can be used along with Chemotherapy, Radiotherapy, Hormone & D.C.
Therapy, etc. for complete cure
•HIFU replaces the need of surgery and is Non Invasive
•HIFU does not require General Anesthesia and a lengthy hospital stay with
immediate return to normal routine
Post operative complications after Surgery:
-Infection, bed rest for 5-15 days
-Poor wound healing
-Fluid collection under the skin or armpit
-Tingling or numbness along the arm
-Stiffness of the shoulder
-Swelling of the arm
-To wear a Breast form, called a prosthesis that fits in the bra after
mastectomy
-Reconstruction cost of breast after 4-6 weeks of surgery by a Plastic
surgeon
-Physiotherapy for arms, etc.
Lymph Nodes are treated today with Sentinel Lymph Node biopsy as
compared to auxillry dissection.
With the use of NUTAS it burns the cancerous tissues, cell by cell as the
temperature goes up to 90 degrees centigrade or above, deep inside the tumor
to completely ablate the cancerous cells within the tumor and we do take
an extra margin of minimum 1 cm around the tumor to treat but nothing
happens on the skin of the patients to treat except some redness and fever
can develop for 2-3 days later on.
AWARENESS ON NUTAS
• It is a matter of time only when people will be made aware of the said
technology available to get treated of their cancerous tumor in an OPD
and there will be immediate freedom from cancer cells present in the
tumor as the same will be burnt completely cell by cell with real time
monitoring of the patient and for confirmation there will be grey
changes in the tumor treated with NUTAS which will be confirmed after
15 days of therapy with path analysis of complete response of necrosis.
• It will reduce the metastasis rate and NUTAS is idle to treat patients in
0-1 stage when it is in non metastasis stage.
• Chemo / Radio / Hormone / D.C. Therapies may or may not be required
as per the clinical advise of Oncologists for complete cure in 0-1 stages
• NUTAS is a replacement of Surgery only in any stage followed by other
therapies for complete cure.
• Follow up of the patients is done by our High End Color Doppler / MRI,
etc. on every 3 / 6 months of treatment with NUTAS
VARIOUS REFERENCES, Youtube Videos ON HIFU TECHNOLOGY & BREAST CANCER
TREATMENT , CLINICAL TRIALS, etc. IN VARIOUS MEDICAL JOURNALS
Wide local ablation of localized breast cancer by HIFU
http://www.ncbi.nlm.nih.gov/pubmed/17443737
.
Clinical trials on Breast Cancer by INSIGHTEC
https://clinicaltrials.gov/ct2/show/NCT01620359
https://clinicaltrials.gov/ct2/show/NCT00008437
A randomised clinical trial of HIFU for the treatment of patients with localized breast cancer
http://www.ncbi.nlm.nih.gov/pubmed/14676799
https://jtultrasound.biomedcentral.com/articles/10.1186/s40349-015-0027-6
Coagulative necrosis
https://en.wikipedia.org/wiki/Coagulative_necrosis
https://en.wikipedia.org/wiki/Necrosis
New hope for Liver Cancer Patients
https://www.youtube.com/watch?v=DHjNSUVBktU
What is Cancer www.cancercentre.com
https://www.youtube.com/watch?v=SGaQ0WwZ_0I
Cancer : From a healthy cell to a Cancer cell
https://www.Youtube.com/watch?v=8LhQllh46yI
Animated introduction to cancer biology
https://www.Youtube.com/watch?v=46Xh7OkkCE
Breast Cancer Treatment Options & Survivors ( Alternative treatment Breast Cancer No-Surgery-Chemo )
HYPERTHERMIA
https://www.Youtube.com/watch?v=VkvOL6-dl_w
The Cancer & Natural Healing of Breast Cancer
https://www.Youtube.com/watch?v=Q5-Cig0VYo
Mastectomy or Lumpectomy for Breast Cancer, Which one is Best?
https://www.Youtube.com/watch?v=8xDTzz53d-U
Lumpectomy Vs Mastectomy Which should I choose?
https://www.Youtube.com/watch?v=DjA2PXLTQ8
Side effects of Radiation Therapy after Breast Cancer
https://www.Youtube.com/watch?v=DHjNSUVBktU

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Nutas presentation

  • 1.
  • 2. INTRODUCED 1st TIME IN INDIA NUTAS BREAST CONSERVANCY THERAPY CENTRE A JOINT VENTURE BETWEEN INCREDIBLE GROUP ( INDIA ) & S.C.T.D.Co. Ltd. ( CHINA )
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  • 9. AWARENESS ON BREAST CANCER BREAST CANCER IS CURABLE NOW WITH PREVENTIVE MEASURES AND BREAST SELF EXAMINATION EARLY DETECTION ALONE CAN SAVE LIVES A FIGHT AGAINST BREAST CANCER, No.1 KILLER DISEASE AMONG WOMEN BECAUSE IT MATTERS TO OUR DEAR WOMEN WOMEN ARE THE BACKBONE OF EVERY FAMILY NO HOUSE IS COMPLETE WITHOUT A WOMAN IN A FAMILY BREAST HEALTH & THE FUTURE OF BREAST CANCER IS IN WOMAN’s HANDS ONLY
  • 10. NO WOMEN IS IMMUMUNE TO GRAND MOTHER DAUGHTER COUSIN MOTHER FRIEND WIFE AUNT NIECE SISTER GRAND DAUGHTER DOCTORS WANTS TO FIND THE CURE FOR THE BREAST CANCER & FOR BREAST CONSERVANCY TO SAVE A WOMAN’s MOST PRECIOUS ORGAN THE BREAST MY PATIENTS ARE WAITING FOR THE SAME ?
  • 11. HELLO DOCTOR WAIT NOW WE HAVE AN ANSWER FOR 100% BREAST CONSERVANCY NUTAS A NON INVASIVE ULTRASOUND TUMOR ABLATION SYSTEM TO ABLATE TUMOR WITH COAGULATIVE NECROSIS WITH EFFECTIVE RATE AS 98.4% THERE WILL BE IMMEDIATE FREEDOM FROM THE CANCEROUS CELLS PRESENT IN THE TUMOR NOW WOMEN CAN SAY NO TO LUMPECTOMY / RADICAL MASTECTOMY
  • 12. A Gift of Beauty and Hope NUTAS IT IS A VICTORY OVER SURGERY & CANCER TREATMENT A CUTTING EDGE TECHNOLGY TO TREAT VARIOUS SOLID TUMORS BREAST CANCER IS CONQUERABLE IF DETECTED IN EARLY STAGES & TREATED WITH NUTAS ALONE OR IN COMBINATION WITH CHEMO / RADIO / HORMONE / D.C.THERAPIES, etc. IT IS A BOON FOR SURGEONS, PATIENTS & GOVT. CANCER HOSPITALS IT IS AN INNOVATION IN THE FIELD OF RADIOLOGY IT CAN TREAT CANCEROUS TUMOR IN BREAST IN 0-1 STAGES WITHOUT SURGERY PLUS IT CAN BE USED IN OTHER STAGES ALONG WITH MULTI MODALITIES TREATMENT OF CHEMO/ RADIO THERAPIES, FOR COMPLETE CURE
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  • 20. NUTAS Breast Conservancy Therapy Centre It was set up in Delhi in April, 2014 and it was inaugurated by the present D.G.H.S., Govt. of India, New Delhi Dr. Jagdish Prasad It is a research product and has 9 Patents regd. in China
  • 21. BREAST CANCER IT IS No. 1 KILLER DISEASE AMOMG WOMEN IN THE WORLD & INDIA IS NOT FAR BEHIND AS THERE WERE 155,367 NEW BREAST CANCER PATIENTS IN THE YEAR 2014 THE SAID FIGURE WILL INCREASE TO 200,000 BY THE YEAR 2020 1 IN 25 PER LAC INDIAN WOMEN ARE AT RISK OF ACQUIRING BREAST CANCER DURING THEIR LIFETIME & IS AN ALARMING SITUATION TO TREAT & CURE WE CAN SAVE WOMEN LIVES WITH EARLY DETECTION ALONE WOMEN MUST TAKE OF THEIR BREAST HEALTH WITH REGULAR BREAST SELF EXAMINATION, HEALTHY DIET, EXCERCISES & PREVENTIVE MEASURES KINDLY VISIT VARIOUS YOUTUBE VIDEOS ON BREAST ANATOMY, B.S.E., BREAST CANCER SYMPTOMS & CONVENTIONAL TREATMENT AVAILABLE TO TREAT BREAST CANCER: https://www.youtube.com/watch?v=L7xjiqGwhW4 https://www.Youtube.com/watch?v=VsviAPGfPUo https://www.youtube.com/watch?v=ga_mHYGgeFM https://www.youtube.com/watch?v=NQvjngIFIiA
  • 22. NOW WOMEN MAY NOT REQUIRED TO UNDERGO CONVENTIONAL TREATMENT OF SURGERY TO TREAT CANNCEROUS TUMOR IN BREAST NOW WOMEN HAVE A CHOICE WITH A NON INVASIVE TREATMENT TO TREAT TUMOR NUTAS IT IS AN ALTERNATIVE FOR SURGERY & TO SAVE THEIR BREAST FROM LUMPECTOMY / MASTECTOMY WITH IMMEDIATE FREEDOM FROM CANCER CELLS PRESENT IN THE TUMOR WHICH WILL REDUCE THE METASTASIS RATE AS WELL FOLLOWED BY CHEMO , RADIO,HORMONE THERAPIES FOR COMPLETE CURE IT IS INCISION LESS, NO BLEEDING, NO GENERAL ANESTHESIA, NO HOSPITALIZATION IT IS RADIATION FREE ENERGY TO ABLATE TUMOR WITH IRREVERSIBLE COAGULATIVE NECROSIS WITHOUT ANY HARM TO THE SURROUNDING HEALTHY TISSUES OR SIDE EFFECTS AND IS 100% BREAST CONSERVANCY THERAPY TO TREAT WITH KINDLY VISIT YOUTUBE VIDEOS FOR DETAILED INFORMATION ON NUTAS SYSTEM : http://www.youtube.com/watch?v=6Dpl1ZNI4XQ https://www.youtube.com/watch?v=FibOgIH6dfw https://www.youtube.com/watch?v=xLPTeB_W_g4
  • 23. I. Principle of NUTAS • Under the guidance of Color Doppler Ultrasound images, NUTAS focuses high intensity ultrasound beams generated in vitro on target lesions inside body. High energy deposition appears in the focal area which destroys tumor cell structure, and results in irreversible coagulative necrosis of tumor tissues. NUTAS treatment applies to the target regions which ultrasound can detect, with good & enough ultrasound path.
  • 24. • According to the size, shape and boundary of tumor, NUTAS automatically generates treatment scheme by using tumor tomography recognition and 3D reconstruction technologies. Then, by controlling the movement of focused ultrasound, it cover the whole tumor, the complete tumor ablation is accomplished. • The temperature of the focal volume of an Ultrasound Beam is rapidly raised to cytotoxic levels to selectively ablate a targeted tumor at depth cell-by-cell & line-by-line layers of cancerous cells present in the tumor to ablate, without any damage to the surrounding or overlying healthy tissues. • Coagulative necrosis is a type of accidental cell death typically caused by ischemia or infarction. In coagulative necrosis the architecture of dead tissue is preserved for at least a couple of days.[1] It is believed that the injury denatures structural proteins as well as lysosomal enzymes thus blocking the proteolysis of the damaged cells. The lack of lysosomal enzymes allows it to maintain a "coagulated" morphology for some time. Like most types of necrosis if enough viable cells are present around the affected area regeneration will usually occur. • Coagulative necrosis can also be induced by high local temperature; it is a desired effect of treatments such as high intensity focused ultrasound applied to cancerous cells.
  • 25. Indications • Breast Tumors: Benign / Malignant, Suggest choosing indications and perform comprehensive treatment; • Liver Tumors: Benign and malignant liver tumors. The tumor which is blocked by rib can be treated by ablating rib or other method to improve the ultrasound path; • Bone Tumors: Original and metastatic tumors except skull and spine; • Pancreatic Tumors: Non-icteric pancreatic tumors or pancreatic tumors which have received jaundice reducing treatment; • Kidney Tumors: Benign and malignant kidney tumors except those with renal vein tumor emboli or inferior vena cava tumor emboli. The tumor which is blocked by rib can be treated by ablating rib or other method to improve the ultrasound path; • Soft Tissue Tumors: Benign or malignant tumors in soft tissue; • Uterine Fibroid; • Benign Prostatic Hyperplasia and Prostatic Cancer; • Retroperitoneal, abdominal and pelvic solid tumors with good ultrasound path.
  • 26. Contraindications • Tumors in gassy and hollow viscera; • Tumors in the central nervous system; • Skin with ulcers or infections in the treated region; • Skin in the treated region that has been treated by radiotherapy over 45Gy; • Tumor thrombi in the vena cava system in the path of an ultrasound wave; • Apparent calcification on an arterial vessel wall in the path of an ultrasound wave; • Patients with major organ failure; • Patients with severe coagulation disorders or definite bleeding tendency; • Patients with major organ failure or whose life cycle is estimated to be within 3 months; • Tumors are not clearly visible in the matched localization image system.
  • 27. A Gift of Beauty and Hope FOR 100% BREAST CONSERVANCY BREAST HEALTH BREAST IS AN ELIXIR OF LIFE TO ENJOY THE BLISSFUL LIFE OF MARRIAGE BREAST MILK IS A LIQUID GOLD & THE ULTIMATE ELIXIR FOR HUMAN LIFE, WOMANHOOD & MOTHERHOOD TO ENJOY THIS BEAUTIFUL WORLD MEN CAN TAKE CARE OF THEIR WIFE BETTER WITH REGULAR B.S.E. DURING.... SO THAT IT REMAINS IN PINK OF HEALTH & FOR SELFISH MOTIVE WOMEN DO FORGET TO TAKE CARE OF THEMSELVES BUT RARELY FORGET TO TAKE PROPER CARE OF OTHERS IN THE FAMILY
  • 28. Who are we? • We have set up a medical centre in Delhi under the name and style NUTAS, Breast Conservancy Therapy Centre in April,2014. • It is an innovation in the field of Radiology to treat various solid tumor ( Benign / Malign ) without Surgery & Radiation to ablate tumor in Breast. • Trials on other solid tumors i.e. in Liver, Kidney, Pancreatic & in Pelvic Area are under process. • NUTAS - is a Non Invasive High Intensity Focused Ultrasound Ablation System and it is based on a trusted scientific technology called HIFU Therapy • Mr. Ashok Arora is a CEO of M/s Incredible Group who has experience in Medical field since 1975 • Mr. Ashok Arora is HIFU Technical Specialist, Entrepreneur and had a vision to enter into a Joint Venture with a Chinese Co. M/s S.C.T.D.Co.Ltd. in Shenyang in the year 2008 to develop an innovative system called NUTAS E-10 a Non Surgical medical device to treat Breast Cancerous tumor without Surgery to ablate a tumor with coagulative necrosis.
  • 29. What is our product / service? • It is the 1st medical centre in India to treat Breast Cancer patient without surgery & radiation to ablate a tumor and is a replacement for surgery followed by Chemo / Radiotherapy / Hormone / D. C. Therapies, etc. for complete cure. • This is the only referral centre in India at the moment to treat and to market the equipment all over India , South East Asia and in Middle East Countries as well. The equipment is being manufactured in China since the year 2000 but after a long research on the same the CE approval of the same was granted in October, 2012 to market the same to treat solid tumors in breast only Benign / Malignant ) • NUTAS is Referral Centre and is a Joint Venture between Incredible Group, Delhi and M/s S.C.T.D.Co. Ltd. of China and we have treated more than 138 breast Cancer patients with success from May,2014 to February,2016 . It was inaugurated by the present D.G.H.S., Dr. Jagdish Prasad. • World is moving from open surgery to Breast conservancy & NUTAS is 100% Breast Conservancy
  • 30. Breast Cancer – The Current Scenario• In India more than 155,000 women new patients were diagnosed to be suffering from Breast Cancer in the year 2014, out of 11 lacs New Cancer patients and this no. will increase to 200,000 by the year 2020 as per WHO report. – India recorded 70,218 deaths from Breast cancer in 2013 – In India (1 in 25 ) Women are at risk and may be diagnosed to be suffering from Breast Cancer in their lifetime and (1 in 10 ) young Indian women are at risk to be diagnosed to be suffering from Fibroadenoma in Breast ( Benign Tumor ) – NUTAS can treat both Benign / Malignant tumors in an OPD under local anesthesia to ablate a tumor irrespective of its size with irreversible coagulative necrosis ( Tissue death of cancer cells present in the tumor) – In Delhi / NCR on an average 10,000 cases of breast cancer surgeries are being carried out in a year in more than 25 dedicated Cancer hospitals in Delhi / NCR • Surgery is the only choice to treat Breast Cancer patients in any stage for treatment along with Chemo / Radio / Hormone therapy, etc. but with Surgery a woman is forced to part with her Breast by Lumpectomy / Mastectomy • The Vision was to replace surgery for Breast cancer patients to save their most precious organ the breast and NUTAS is the answer for 100% Breast
  • 31. . HOW BREAST CANCER DEVELOPS ? BREAST CANCER IS A CANCER THAT STARTS IN THE TISSUES OF THE BREAST AND THERE ARE TWO MAIN TYPES OF BREAST CANCER : •DUCTAL CARCINOMA STARTS IN THE TUBES OF DUCTS THAT MOVE MILK FROM THE BREAST TO THE NIPPLE •MOST BREAST CANCERS ARE OF THIS TYPE •LOBULAR CARCINOMA STARTS FROM THE PART OF THE BREAST CALLED THE LOBULES WHICH PRODUCE MILK
  • 32. WHAT IS NUTAS ? It is Non – Invasive Focused Ultrasound Treatment As a non-invasive method of lumpectomy, focused ultrasound may offer the following benefits in treating breast cancer: •No post operative complications and a very short recovery time, compared with surgical lumpectomy; •No scar tissue and no risk for breast deformation; •Zero risk for infection; and •More precise treatment as a result of real-time guidance by Ultrasound Guided FUS With increased precision, focused ultrasound has the potential to be a more effective lumpectomy than surgery Thus it could potentially be a primary treatment approach for various patients in future to be treated initially with HIFU technology and to save a woman’s most precious organ the breast from Lumpectomy / Mastectomy or any other organs required to be treated with for a speedy treatment in an OPD and there is no Surgical removal of tissue involved.
  • 33. HOW EFFECTIVE IS SURGERY AS A CURE ? According to Dr. Kapil Kumar a renowned Breast Cancer surgeon has mentioned on 18th March, 2016 in an interview to TOI, that Surgery is most effective in the EARLY stages when the cancer is in-situ or has not spread and is in non-metastasis stage and it means that Surgery is not effective in stage II & III and in stage IV it is not recommended by the surgeons. Whereas NUTAS treatment is ideal in EARLY stages of 0-I and can be advised in II,III & IV as well stages being Non–Invasive, as a Palliative treatment and is the safest treatment to ablate a tumor and will reduce metastasis rate followed by various modes of treatment available for complete cure instead of waiting for surgeries.
  • 34. WHICH TREATMENT IS BETTER SURGERY OR NUTAS NUTAS -A BOON FOR SURGEONS, PATIENTS & GOVT.EXCHEQUER TO SAVE ON COST OF SURGER- IES & HOSPITAL BEDS, O.T. EXPENSES, MEDICINES, DISPOSABLES, POST OPERATIVE CARE, etc. NO INCISION, NO BLEEDING, NO GENERAL ANESTHESIA, NO HOSPITALIZATION, NO BED REST, NO MEDICINES FOR HEALING, NO SIDE EFFECTS, AN OPD BLOODLESS PROCEDURE, SAFE & RADIATION FREE ENERGY TO ABLATE TUMOR WITH IRREVERSIBLE COAGULATIVE NECROSIS SURGEONS -WILL REMOVE THE BENIGN / MALIGNANT TUMOR WHICH WILL DEFORM / REMOVE THE WHOLE BREAST, THE MOST PRECIOUS ORGAN OF A WOMAN WITH HOSPITALIZATION, BED REST & MEDICINES TO HEAL THE WOUND & RECONSTRUCTION COST OF BREAST CHEMOTHERAPIES – IT REQUIRES MINIMUM 3-12 SESSIONS IN AN INTERVAL OF 21-45 DAYS TO KILL CANCER CELLS PRESENT IN THE TUMOR OR IN THE BODY. CONFIRMATION REQUIRES SEVERAL TESTS OVER A PERIOD OF YEAR & ABOVE RADIOTHERAPY – IT REQUIRES MINIMUM 35 SITTINGS IN 5 WEEKS OF CONTINUOUS RADIATION THERAPY TO KILL THE CANCEROUS CELLS IN TUMOR , etc. CONFIRMATION REQUIRES SEVERAL TESTS NUTAS – IT BURNS THE CANCEROUS CELLS PRESENT IN THE TUMOR IN AN HOUR, CELL BY CELL WITH REAL TIME MONITORING ON SCREEN, IN ONE SITTING WITHOUT ANY SURGICAL KNIVES WITH IMMEDIATE FREEDOM FROM METASTASIS & CONFIRMED REPORT AFTER 15 DAYS ONLY
  • 35. ABSTRACT ON NUTAS IT CAN BE RECOMMENDED SAFELY FOR TREATMENT BY PHYSICIANS / SURGEONS IT IS RADIATION FREE ENERGY TO ABLATE TUMOR WITH IRREVERSIBLE COAGULATIVE NECROSIS in ONE SITTING OR IS REPEATABLE IT HAS NO POST OPERATIVE COMPLCATIONS AS COMPARED TO SURGERY IT IS HARMLESS FOR SURROUNDING HEALTHY TISSUES IT WILL BURNT THE CANCER CELLS PRESENT IN THE TUMOR IN ONE SITTING WHICH WILL REDUCE METASTASIS WITH IMMEDIATE FREEDOM FROM CANCER CELLS PRESENT IN THE TUMOR WHICH IS THE PRIMARY SOURCE OF SPREAD OF CANCER IN THE BODY IT CAN BE TREATED SAFELY WITH NUTAS ALONE IN 0-1 STAGES OR IN NON METASTASIS STAGE OR WITH ADJUVANT THERAPY AS PER THE CLINICAL ADVICE OF ONCOLOGISTS IT CAN ALSO BE RECOMMEMNDED SAFELY FOR PALLIATIVE TREATMENT IN II – IV STAGES AS WELL ALONG WITH MULTI MODALITIES OF TREATMENT FOR COMPLETE CURE
  • 36. NUTAS TREATMENT PROTOCOL FOR TREATING BREAST CANCER IN VARIOUS STAGES AS PER THE RECOMMENDATIONS OF THE TUMOR BOARD & ONCOLOGISTS TO TREAT WE TREAT AGAINST CONFIRMED TRUE CUT / CORE BIOPSY REPORT COMPLETE WITH ER / PR / HER2 nue STATUS ONLY WITH MULTI MODALITIES OF TREATMENTS AVAILBLE FOR COMPLETE CURE WITH NUTAS THERAPY WE CAN BURNT / KILL THE CANCER CELLS PRESENT IN THE TUMOR ONLY IT IS 100% BREAST CONSERVANCY FOR PATIENTS DIAGNOSED WITH BREAST CANCER & WOMEN CAN SAY BYE-BYE TO LUMPECTOMY / MASTECTOMY Stage T 0 – T 1 = NUTAS + CHEMO OR NUTAS + HOMEOTHERAPY ( 9 Months Treatment Course to reduce CA Level ) OR NUTAS + COW URINE THEARPY ( Govt. Approved AUYERVEDIC ) OR NUTAS + D.C . Therapy Stage T 2 = NUTAS + CHEMO + RADIO OR NUTAS +HOMEO FOR 9 MONTHS / Cow Urine Therapy OR NUTAS + D.C. Therapy Stage T 3 = NUTAS + CHEMO + RADIO OR NUTAS + CHEMO + RADIO + HOMEO/ COW URINE THERAPY OR NUTAS + D.C. Therapy Stage T 4 = NUTAS + CHEMO + RADIO + HOMEO / COW URINE THERAPY OR NUTAS + D.C. Therapy NUTAS – It can be used to treat Tumor Benign / Malignant in Breast and the Breast too can be saved as well.
  • 37. CLINICAL TRIALS ON BREAST CANCER BY HIFU TECHNOLOGY British Journal of Cancer (2003) 89, 2227–2233. doi:10.1038/sj.bjc.6601411 www.bjcancer.com Published online 12 December 2003 A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer 1 Institute of Ultrasonic Engineering in Medicine, and Clinical Center for Tumor Therapy of 2nd Hospital, Chongqing University of Medical Sciences, Box 153, 1 Medical College Road, Chongqing 400016, China Correspondence: Dr F Wu, E-mail: mfengwu@yahoo.com Received 24 April 2003; Revised 26 August 2003; Accepted 12 September 2003 Abstract High-intensity focused ultrasound (HIFU) is a noninvasive treatment that induces complete coagulative necrosis of a tumour at depth through the intact skin. This study was to explore the possibility of using HIFU for the treatment of patients with localised breast cancer in a controlled clinical trial. A total of 48 women with biopsy-proven breast cancer (T1–2 , N0–2 , M0 ) were randomised to the control group in which modified radical mastectomy was performed, and the HIFU group in which an extracorporeal HIFU ablation of breast cancer was followed by modified radical mastectomy. Short-term follow-up, pathologic and immunohistochemical stains were performed to assess the therapeutic effects on tumour and complications of HIFU. The results showed that no severe side effect was observed in the HIFU-treated patients. Pathologic findings revealed that HIFU-treated tumour cells underwent complete coagulative necrosis, and tumour vascular vessels were severely damaged. Immunohistochemical staining showed that no expression of PCNA, MMP-9, and CD44v6 was detected within the treated tumour cells in the HIFU group, indicating that the treated tumour cells lost the abilities of proliferation, invasion, and metastasis. It is concluded that, as a noninvasive therapy, HIFU could be effective, safe, and feasible in the extracorporeal treatment of localised breast cancer. Keywords: high-intensity focused ultrasound; focused ultrasound surgery; breast carcinomas; therapy; ablation
  • 38. TREATMENT PRINCIPLE OF NUTAS : Under the guidance of Color Doppler Ultrasound images, NUTAS focuses high intensity ultrasound beams generated in vitro on target lesions inside the body. High energy deposition appears in the focal area which destroys tumor cell structure and results in irreversible coagulative necrosis of tumor tissues, according to the size, shape and 3D reconstruction technologies. Then, by controlling the movement of focused ultrasound the whole tumor, the complete tumor ablation is accomplished.
  • 39. PROMISING RESULTS ON BREAST CANCER STUDY WITH HIFU : Dr. Alessandro Napoli, M.D., Ph.D., assistant professor of radiology at Sapienza University in Rome, presented the results of his study involving 12 patients with invasive ductal breast cancer. All patients were treated with FUS, and post- treatment, histological evaluation confirmed the absence of residual disease in the treatment area in 10 patients. Though this study is part of early stage research Dr. Napoli is hopeful that focused ultrasound will one day be a treatment option for women with Breast cancer The Doctors at Churchill Hospital in Oxford (Radcliffe Hospitals NHS) where Professor Sir Peter Morris, President of Royal College of Surgeons say Breast cancer patient’s lumps could instead be “zapped” with ultrasound, sparing them the trauma of breast removal.
  • 40. NUTAS is a Cancer Treatment of 21st Centaury Imagine being treated for cancer in an outpatient setting No Hospital Stay, No Surgery, Non Incision, No Radiation, No Side effects, No Dysfunctions of Limbs & Organs (Equivalent to Surgery) It is a One Time Treatment Cost for the patients to go through, avoids the costly expenses of treatment of Cancer & Reconstruction cost of Breast as it is a trauma for a women to live without her most precious organ the Breast It is a Revolutionary Approach for Tumor Treatment with Remote Non – Invasive Surgery & the only system in the World to treat with NO DELAY to treat patients diagnosed to be treated
  • 41. ADVANTAGES OF HIFU / NUTAS THERAPY •HIFU is Radiation free energy which kills the cancer cells by focused High Intensity Ultrasounds in the solid tumor to treat which will burn the cancer cells present in the tumor only without affecting the surrounding healthy tissues & the tumor residue after treatment with NUTAS will be autolysed by Phagocytes as it happens in Radiotherapy & RFA irrespective of tumor size to treat with •HIFU treatment has no side effects or any damaging side effects than conventional treatment with surgical procedure •HIFU can be used along with Chemotherapy, Radiotherapy, Hormone & D.C. Therapy, etc. for complete cure •HIFU replaces the need of surgery and is Non Invasive •HIFU does not require General Anesthesia and a lengthy hospital stay with immediate return to normal routine
  • 42. Post operative complications after Surgery: -Infection, bed rest for 5-15 days -Poor wound healing -Fluid collection under the skin or armpit -Tingling or numbness along the arm -Stiffness of the shoulder -Swelling of the arm -To wear a Breast form, called a prosthesis that fits in the bra after mastectomy -Reconstruction cost of breast after 4-6 weeks of surgery by a Plastic surgeon -Physiotherapy for arms, etc. Lymph Nodes are treated today with Sentinel Lymph Node biopsy as compared to auxillry dissection. With the use of NUTAS it burns the cancerous tissues, cell by cell as the temperature goes up to 90 degrees centigrade or above, deep inside the tumor to completely ablate the cancerous cells within the tumor and we do take an extra margin of minimum 1 cm around the tumor to treat but nothing happens on the skin of the patients to treat except some redness and fever can develop for 2-3 days later on.
  • 43. AWARENESS ON NUTAS • It is a matter of time only when people will be made aware of the said technology available to get treated of their cancerous tumor in an OPD and there will be immediate freedom from cancer cells present in the tumor as the same will be burnt completely cell by cell with real time monitoring of the patient and for confirmation there will be grey changes in the tumor treated with NUTAS which will be confirmed after 15 days of therapy with path analysis of complete response of necrosis. • It will reduce the metastasis rate and NUTAS is idle to treat patients in 0-1 stage when it is in non metastasis stage. • Chemo / Radio / Hormone / D.C. Therapies may or may not be required as per the clinical advise of Oncologists for complete cure in 0-1 stages • NUTAS is a replacement of Surgery only in any stage followed by other therapies for complete cure. • Follow up of the patients is done by our High End Color Doppler / MRI, etc. on every 3 / 6 months of treatment with NUTAS
  • 44. VARIOUS REFERENCES, Youtube Videos ON HIFU TECHNOLOGY & BREAST CANCER TREATMENT , CLINICAL TRIALS, etc. IN VARIOUS MEDICAL JOURNALS Wide local ablation of localized breast cancer by HIFU http://www.ncbi.nlm.nih.gov/pubmed/17443737 . Clinical trials on Breast Cancer by INSIGHTEC https://clinicaltrials.gov/ct2/show/NCT01620359 https://clinicaltrials.gov/ct2/show/NCT00008437 A randomised clinical trial of HIFU for the treatment of patients with localized breast cancer http://www.ncbi.nlm.nih.gov/pubmed/14676799 https://jtultrasound.biomedcentral.com/articles/10.1186/s40349-015-0027-6 Coagulative necrosis https://en.wikipedia.org/wiki/Coagulative_necrosis https://en.wikipedia.org/wiki/Necrosis New hope for Liver Cancer Patients https://www.youtube.com/watch?v=DHjNSUVBktU What is Cancer www.cancercentre.com https://www.youtube.com/watch?v=SGaQ0WwZ_0I Cancer : From a healthy cell to a Cancer cell https://www.Youtube.com/watch?v=8LhQllh46yI
  • 45. Animated introduction to cancer biology https://www.Youtube.com/watch?v=46Xh7OkkCE Breast Cancer Treatment Options & Survivors ( Alternative treatment Breast Cancer No-Surgery-Chemo ) HYPERTHERMIA https://www.Youtube.com/watch?v=VkvOL6-dl_w The Cancer & Natural Healing of Breast Cancer https://www.Youtube.com/watch?v=Q5-Cig0VYo Mastectomy or Lumpectomy for Breast Cancer, Which one is Best? https://www.Youtube.com/watch?v=8xDTzz53d-U Lumpectomy Vs Mastectomy Which should I choose? https://www.Youtube.com/watch?v=DjA2PXLTQ8 Side effects of Radiation Therapy after Breast Cancer https://www.Youtube.com/watch?v=DHjNSUVBktU