hepatorenal combined histopathology gulshan serum creatinine blood urea nitrogen alp sgot sgpt nephroprotective hepatoprotective gsh ldh sod abts dpph antioxidant dhb nephrotoxicity hepatotoxicity pathways granzyme perforin intrinsic extinsic pathway lifescience m pharm b pharm pharmacology 2023 latest programmed cell death autophagy necroptosis necrosis cell death apoptosis
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