We present the latest developments around the Biopharma Navigator, a consolidated large search, analysis and reporting application for tens of millions of biomedical documents. In its latest version the application has expanded to include yet more document sources, is offering real-time data-driven dashboards, an enhanced API that facilitates integration into third-party environments, advances in expert identification, the extension of the pharmacovigilance approach to new sources from news and social media as well as live extension of drug name repositories and clinical trial monitoring. The Biopharma Navigator is used by a growing number of experts in the industry for their daily analyses and can be employed either on a simple subscription basis or with an on-premise installation. The Biopharma Navigator is our answer for the question how big data, cognitive computing analysis and intuitive webfrontends can be combined to provide broad and up-to-date information access to Life Science professionals.

1. Navigating to new shores –
The Biopharma Navigator
Stefan Geißler, Archna Bhandari, Gilles Pouzenc,
Expert System
II SDV, Nice, April 23, 20918

2. ▪ Software provider: Largest
European vendor
of Text Analytics & Cognitive
Computing
▪ Publicly listed (EXSY)
with offices and R&D labs in
Europe and USA
▪ Patented technology: Cogito!
▪ The technology of choice
corporate clients in many
sectors: BASF, Swiss Re, Zurich,
Daimler, Sanofi, Lloyd’s, Europol
and many, many others
Who we areExpert System

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Biopharma Navigator
• Webbased search, analysis and reporting
solution
• Broad coverage of life science content,
constantly up to date
• Powerful text analytics, simple web frontend
• Available inhouse or as SAAS
• Validated by (and developed in cooperation
with) large industry user community

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We all know this situation!
Multiple Data Sources!

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How do I Navigate Complex Data Landscape?
Clinical Trials
Publications
Regulatory
Grants
Patents
Other…
News Releases
Time Consuming Process
n…n+1

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User Feedback
• One Stop Search
• One Tool; One Interface
• Multiple Sources; Linked Together
• Easy Navigation
• Like Google, but More Powerful
• Better On-target Results
• Combine the best of both worlds
• Real-time Data + Customization
• One View: 1+1=3!
Friendly, faster and reliable information!

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Real-Time
• SaaS
• Point Solutions
• Standard
Navigator
Value Proposition
Custom
• Report Form
• DIY or Outsourced
• … but Static
Custom AND Real-Time
Better Decisions…Faster!

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User Adoption
Supporting over 1,400 Researchers, Analysts and Executives @ SANOFI
0
200
400
600
800
1000
1200
1400
Nov '14 Feb '15 Mai '15 Aug '15 Nov '15 Feb '16 Mai '16 Aug '16 Nov '16 Feb '17 Mai '17 Aug '17 Nov '17

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Area of
Interest
Publications
MEDLINE
Daily
Grants
NIH & RCUK
Weekly
Patents
USPTO
Weekly
News
Releases &
Twitter
Every 30
MinutesFDA Orange
Book
Monthly
FDA
Adverse
Events
FDA
Release
Schedule
Clinical
Trials USA,
Europe,
WHO, etc.
Daily to
Weekly
Experts
Multiple
Sources
Daily
Navigator Data Sources
>17M
>450K
> 7M
>2.2M
>46K
>450K
>10M
>48M
Internal &
Other
Sources
Integrated, Normalized and Linked Data to speed up analysis!
Sunshine
Act

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Data Challenges: Disambiguation,
Normalization, Linking!
Example: Company Names
There are two companies “Merck” and the user expects
them to be presented in a disambiguated way
This is the reality when looking at raw data

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Data Challenges
How should I Search for a Drug Name or a Target?
PF-
05280586
Lab Code
Rituximab
INN Name
Rituxan
Brand
Name
Drug Activity
Drug/target/MoA association enables
more precise and relevant results!

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Data Challenges
Amyotrophic
Lateral
Sclerosis
ALS
Charcot
Disease
Gehrig
Disease
Lou Gehrig
Disease
Motor
Neuron
Disease,
ALS
Sclerosis,
Lateral
Amyotrophic
How should I Search for a Condition/Disease Name?

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Data Challenges
Clinical
Trials
Clinicaltrials
.gov
Registry
European
Registry
Australian
Registry
Japanese
Registry
WHO ICTP &
Others
Publication
News
Where Do I Find All/Unique Clinical Trials?

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Experts
Principal
Investigators
(PI)
Clinical
Trials
Authors
Publications
Inventors
Patents
Grantees
Funded
Grants
Data Challenges
Where do I Find Experts?
Who Works
with Whom?
Who is Who?
(Name Ambiguity)

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Navigator Vocabularies
Standard and In-house
Condition*
Disease, Disorder,
Syndrome
Intervention*
Drugs-Chemical
& Biological type
Organization**
Companies,
Universities, Agencies,
Institutions
* Combination of Standard Vocabularies and In-house development
** In-house development
All vocabularies are reviewed, curated and customized on an ongoing basis by the Navigator team
Target*Mechanism of
Action**
Phase**Location*

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Navigator Platform
High Level Architecture
Management & Curation
Application
Analytics
Application
Back-end Services
SolR Search
Engine
MongoDB
Database
Data
Analytics
and
Reporting
Content
Enrichment
Ingestion
Pipeline
Text Analytics and NLP
Engine
SearchContent
Crawlers
Web API

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Biopharma Navigator: more than
faceted search!
• Integration of the Expert System
NLP platform Cogito
• Built-in knowledge graph of
several hundred thousand
concepts and their relations
• Disambiguation: determine the
meaning of terms from the context
• Syntactic parsing: determine the
roles of terms from the context
• Anaphora resolution and linking
• Generate human readable (and
refinable) models from training
data

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Benefits
Some examples:
• Mining of trial announcements from unstructured text:
companies, clinical phase, timeline
 trial landscape beyond published data from ClinicalTrials.gov
• Detection of new drugs from unstructured text
drug beyond what is listed in predefined vocabularies
• Disambiguate, normalize and link entities like experts
(people), substances, organizations
 BPN knows background info about a drug so when search e.g.
for a target X, it returns information on substances that target X

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Sample use cases

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One Stop Search
Single Integrated Platform - for simple questions
Identify Competitive Landscape
related to global clinical trials
CLINICAL TRIALSCLINICAL TRIALS
Find Experts and know their
research network: over 10 million
& growing
EXPERTSEXPERTS
Find Latest News: Syndicated,
regulatory & company news,
updated every 30 minutes
NEWSNEWS
Multiple Access Points for Different Use Cases!

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Easy Navigation & Analysis
When your questions are more complex
CONDITIONSCONDITIONS SPONSORSSPONSORS COUNTRYCOUNTRY
PHASE CHARTPHASE CHARTMECHANISM OF ACTIONSMECHANISM OF ACTIONSINTERVENTIONSINTERVENTIONS
No more Pivots Tables! No more Chart Tools!
Access to source data at your fingertips!

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Data Augmentation
Where CI analysts add context and extra value
Combine Primary Intelligence with Secondary Data!

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Real-time Data
Automatically updated from original sources
Pipeline Chart
Timeline Chart
Bullseye Chart
Always Up-to-date: No More Cutting & Pasting!

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Dissemination On-demand
Customized News
One View: Disseminate customized information to targeted
stakeholders!

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Thank you for your attention!
Biopharma Navigator online at
https://www.biopharmanavigator.com/bpn/
Test access available (no obligation, full functionality)
Contact: www.linkedin.com/in/stefangeissler