1. Performance and Security of Internet Applications John Buten Manager, Enterprise Industries jbuten@akamai.com

2. Akamai Confidential POWERING A BETTER INTERNET Who is Akamai? Leader in powering rich media, dynamic transactions and enterprise applications online Proven to speed dynamic Web sites and applications by up to 500% $860MM in Revenue 2009 NASDAQ: AKAM 3,100+ Customers 1,400+ Employees

3. Evolution of Health Information Internet Fax Post EDI

4. Imperatives of Health 2.0 Performance Matters Size Matters Security Matters Location Matters Akamai Confidential POWERING A BETTER INTERNET

5. 1. Performance Matters Akamai Confidential POWERING A BETTER INTERNET 8 Seconds 4 Seconds 0 2 4 6 10 8 Response Time (seconds) Over 50% of consumers expect pages to load in 2 seconds or less Consumer Expectation for Page Load 1999 2006 Source: Jupiter Research Source: Forrester Research 2009 2 Seconds North American consumers

6. 1. Performance Matters Akamai Confidential POWERING A BETTER INTERNET Sites are getting heavier and slower, not lighter and faster 20 2.4 seconds/100KB 18 16 14 12 10 Page Response Time (Seconds) 8 6 4 2 0 50 100 150 200 250 0 300 Page Weight (KB) Source: Akamai - global average page response of

7. 2. Size Matters Akamai Confidential Web sites are critical point of communication in moment of truth

8. 2. Size Matters Akamai Confidential POWERING A BETTER INTERNET Web sites are critical point of communication in moment of truth

9. 3. Security Matters Healthcare and Pharmaceutical lead other industries with a poor 50% SocialNetworking HighTech FinancialServices Insurance Retail Pharma Telecomm Health Source: White Hat Security, 2009

10. 3. Security Matters Data theft is real as are the consequences 130 million accounts compromised $100 million in fines to card issuers 200-500,000 records compromised Forced to notify members 29,000 employee records compromised 15,000 patient records compromised $200,000 in fines

11. 4. Location Matters Akamai Confidential POWERING A BETTER INTERNET Healthcare and Pharmaceutical lead other industries with a poor 50%

12. 4. Location Matters Clinical research is a global endeavor Asia 4% +93% D Europe 18% +25% D North America 76% +6% D Countries with Rave Sites Medidata Offices Outsourced Locations Data Center South America 1% +165% D R&D Spend Analysis (PhRMA Members, 07) % of Worldwide Total R&D Spend % Change in Spend 06-07 POWERING A BETTER INTERNET

14. 8+ million hits per second

15. 100+ million streams / day

16. 1,000,000+ concurrent streams

18. Akamai enables richer Web experiences 20 2.4 seconds/100KB 18 16 14 12 10 Page Response Time (Seconds) Without Akamai 8 With Akamai 6 4 0.7 seconds/100KB 2 0 50 100 150 200 250 0 300 Page Weight (KB)

19. Akamai Flattens the Globe Akamai Confidential POWERING A BETTER INTERNET Online Transaction Speed (seconds)

20. Akamai Inherent SecurityProtecting Applications in the Cloud Akamai’s 60,000+ servers act as a distributed firewall Resources for outclassing any DDOS or DNS attack Lock down your application to unknown traffic

21. Questions / Réponses John Buten Manager, Enterprise Industries jbuten@akamai.com