Alcon Google Innovation "Visions of Ophthalmology in 2020" presented at OIS@AAO 2015

1. Alcon – Google Innovation:
Visions of Ophthalmology in 2020
Moderated By: Panel Participants:

2. a Novartis company
Future Technology in Eye Care
Franck Leveiller
Vice President, Head R&D Surgical franchise
Alliance Manager Alcon-Google partnership

3. The Intersection of the Eye and Technology

4. [X] Marks the Spot...

5. In July 2014, Novartis and Google announced
collaboration...

6. Alcon focus is to address unmet medical needs for patients in eye
care... by potentially applying “smart lens” technology
• 20 million blind from treatable cataracts1
• 25 million with AMD2
• 67 million with glaucoma3
• 1.7 billion people with presbyopia4
• 90% of problems can be prevented,
treated or cured1,5,6
1) International Agency for the Prevention of Blindness (IAPB), Global Facts, http://www.iapb.org/vision-2020/global-facts │ 2) World Health Organization. Vision 2020: The Right to Sight.
http://www/whoint/blindness/Vision_2020_report.pdf. (Accessed September 26, 2012) │ 3) Lighthouse International. Prevalence of Vision Impairment. http://www.lighthouse.org/research/statistics-on-vision-
impairment/prevalence-of-vision-impairment/. │ 4) Market Scope, Global Presbyopia-Correcting Surgery Market Report, April 2012 │ 5) Brien Holden Vision Institute, Vision Correction Needs,
http://www.brienholdenvision.org/research/vision-correction-needs.html. │ 6) World Health Organization (WHO: Blindness: Visual Impairment and Blindness. (Updated June 2012)
http://www.who.int/mediacentre/factsheets/fs282/en/index.html (Accessed March 29, 2013)

7. Novartis Interest in the Google “Smart Lens”
Technology Currently Focused in Two Areas
Helping diabetic patients manage
their disease by providing a continuous,
minimally invasive measurement of the
body’s glucose levels via a “smart
contact lens”
For people living with presbyopia who
can no longer read without glasses, the
“smart lens” has the potential to help
restore the eye’s natural focusing
ability on near objects
1. Ophthalmic Biosensing 2. Functional Improvement

8. Alcon-Google Collaboration Can Transform Eye Care
• “10x mindset” and passion
• Ultra-fast prototyping
• Miniaturization excellence
Glucose-sensing
Contact Lens
Accommodating
Contact Lens
Accommodating
IOL
• Medical device leadership
• Deep pharmaceuticals expertise

9. While Many Possible Configurations Exist, the
Goal is to Empower Actions with Data
Smart Lens
Mobile
Storage/
Analytics
Sensor data/config
Actionable
feedback

10. Upcoming Biosensor Challenges
• Patient Privacy
– Despite the many advantages (ease of use, sharing data with HCPs,
potential for analytics, etc.), some patients may not be comfortable
with personal health data being stored on cloud-based systems
– Additionally, concerns may arise around healthcare payers using
personal health data to potentially deny reimbursement of medical
expenses
• Regulatory Issues
– Agencies will need to continually adapt regulations on mobile
medical applications to support innovative ways to enhance health and
healthcare delivery
– Multiple branches of Regulatory bodies will need to work together to
thoroughly review “smart device” submissions

11. We’ve Barely Tipped the Innovation Scale
• Our eyes are the window into
the body’s systemic conditions
• The promising impact of
innovation spurs continued
investment
• Innovation is critical in ensuring
healthy vision as we age
• The merger of technology and
healthcare will provide
improved patient outcomes

12. a Novartis company