Introduction of The OIS Index at OIS@AAO 2016. Presenter: Michael Lachman, Founder - EyeQ Research Powered by: Healthegy For more ophthalmology innovation Visit us at www.ois.net

1. Introduction:
OIS@AAO ■ Chicago ■ October 13, 2016
Michael E. Lachman
© Copyright 2016 EyeQ Research and Healthegy/OIS

2. October 13, 2016 ■ Page 1
Stock Market Indices
US Broad Market Indices
 Dow Jones Industrial Average
 S&P-500
 Russell 3000
International Market Indices
 Nikkei 225 (Tokyo), FTSE 100 (London), DAX Index (Frankfurt)
Market Sector Indices
 Dow Jones Transportation and Utility Averages
 NASDAQ Biotechnology Index

3. October 13, 2016 ■ Page 2
Introducing the OIS Index
October 1, 2016
1,000.00

4. October 13, 2016 ■ Page 3
OIS Index Methodology
Mid-Cap and Small-Cap Ophthalmic Companies
 Publicly Traded
 ≥ 50% Ophthalmology
 Initial Composition: 70% Biopharma, 30% Ophthalmic Device
Market Cap Weighted, with Limits
 Largest Companies Capped at 10% of Total Index Value
 Others Capped at 8% and 6%
Updated and Rebalanced Quarterly
 IPOs, Acquisitions, Share Counts
 30 - Eleven = 29

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OIS Index Components
Mkt.
Cap
Raw
Pct.
Adj.
Pct.
C. Zeiss Meditec $3,091 24% 10.0%
Spark Therap. $1,839 14% 8.0%
Ophthotech $1,642 13% 8.0%
Glaukos $1,246 9.6% 8.0%
Aerie Pharma. $1,102 8.5% 8.0%
Molecular Part. $529 4.1% 6.0%
Omeros $477 3.7% 6.0%
STAAR Surgical $380 2.9% 5.8%
Clearside Bio. $356 2.8% 5.4%
Inotek Pharma. $255 2.0% 3.9%
NicOx $231 1.8% 3.5%
GenSight Bio. $191 1.5% 2.9%
AGTC $177 1.4% 2.7%
Ocular Therap. $171 1.3% 2.6%
Adverum Bio. $170 1.3% 2.6%
Mkt.
Cap
Raw
Pct.
Adj.
Pct.
Second Sight $149 1.2% 2.3%
Iridex $147 1.1% 2.2%
Thrombogenics $116 0.9% 1.8%
pSivida $103 0.8% 1.6%
Aldeyra Therap. $98 0.8% 1.5%
Alimera Sci. $94 0.7% 1.4%
Ohr Pharma. $91 0.7% 1.4%
Opthea $84 0.7% 1.3%
Presbia $58 0.5% 0.9%
Imprimis $50 0.4% 0.8%
NovaBay Pharm. $46 0.4% 0.7%
TearLab $34 0.3% 0.5%
Eyegate Pharm. $16 0.1% 0.3%
Escalon Med. $5 .04% .08%

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OIS Index – Six Month Performance
April 1 – October 1, 2016 OIS Index +22%
Total US Market +6%
US Medical
Devices + 19%
NASDAQ
Biotechnology
Index + 11%
Total US market based on Russell 3000 Index (^RUA)
US medical devices based on iShares US Medical Devices ETF (IHI)
Equity valuations from MarketXLS

7. October 13, 2016 ■ Page 6
OIS Index – Key Drivers of Performance
April 1 – October 1, 2016
Aerie Pharmaceuticals
Glaukos
Spark Therapeutics
Clearside BioMedical
Omeros
AGTC
Molecular Partners

8. We Invite Your Feedback… Thank You!
Michael E. Lachman ■ michael@EyeQResearch.com
Craig Simak ■ craig@healthegy.com
© Copyright 2016 EyeQ Research and Healthegy/OIS

9. October 13, 2016 ■ Page 8