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Refractory Cardiac Arrest
Stephen Bernard
MD FACEM FCICM FCCM ASM
The Victorian setting: Refractory Arrest
– 12 month period (2012)
– Age < 65 years
– VF as initial cardiac rhythm
• 222 patients
• 149 (67%) ROSC
• (Survival of these = 55%)
• 68 no ROSC
• 5/68 transported with CPR (Autopulse)
• 63 declared deceased at scene
The Victorian setting: Refractory Arrest
– 12 month period (2012)
– Age < 65 years
– VF as initial cardiac rhythm
• 222 patients
• 149 (67%) ROSC
• (Survival of these = 55%)
• 68 no ROSC
• 5/68 transported with CPR (Autopulse)
• 63 declared deceased at scene
Refractory Arrest
– No ambulance transport
due to:
• Risk of unrestrained
CPR
• “Futility”
The CHEER Trial
– Pilot observational trial
– Refractory cardiac arrest
– No ROSC at 30 minutes
• CPR mechanical to The Alfred ED
• Hypothermia with IV cold saline
• ECMO
• Emergency
• Reperfusion
Stub D, Bernard S, Pellegrino V, et al. Refractory cardiac arrest treated with mechanical CPR,
hypothermia, ECMO and early reperfusion (the CHEER Trial) Resuscitation 2015; 86:88-94
HERALD SUN 2/9/16 THE MAN DOCTORS BROUGHT
BACK TO LIFE AFTER BEING DEAD FOR 73 MINUTES
A MELBOURNE man has been brought back to life after spending a
staggering 73 minutes clinically dead. Robert Kinderman has praised his
survival as a miracle, while his stunned doctors at The Alfred hospital say
his remarkable case redefines what is possible for cardiac arrest patients
around the world.
What
about
me? 
What
about
me? 
Non-ECPR treatments for refractory cardiac arrest
Mechanical CPR to cardiac catheterisation laboratory?
New anti-arrhythmics? Wagner H, et al. Cardiac arrest in
the catheterisation laboratory: a
5-year experience of using
mechanical chest compressions
to facilitate PCI during prolonged
resuscitation efforts.
Resuscitation 2010; 81:383-7 3.
Driver BE, et al. Use of esmolol
after failure of standard
cardiopulmonary resuscitation to
treat patients with refractory
ventricular fibrillation.
Resuscitation 2014; 85:1337-41
Refractory Arrest:
“CHEER2” Clinical Practice
Guideline
Commenced 8/10/15
29 LUCAS2™ CPR
machines for transport to
metro ED for ECMO or
Cath lab
Refractory Arrest in Rural:
Autopulse™ in rural Victoria
for “extra pair of hands”
14 Units available
Issues about fitting in car
?Transport to ED
?Transport by HEMS
The RINSE trial:
The RINSE trial:
The RINSE trial:
Thank you!
s.bernard@Alfred.org.au
@AmbVicMedic

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Bernard - Refractory Cardiac Arrest

  • 1. Refractory Cardiac Arrest Stephen Bernard MD FACEM FCICM FCCM ASM
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8. The Victorian setting: Refractory Arrest – 12 month period (2012) – Age < 65 years – VF as initial cardiac rhythm • 222 patients • 149 (67%) ROSC • (Survival of these = 55%) • 68 no ROSC • 5/68 transported with CPR (Autopulse) • 63 declared deceased at scene
  • 9. The Victorian setting: Refractory Arrest – 12 month period (2012) – Age < 65 years – VF as initial cardiac rhythm • 222 patients • 149 (67%) ROSC • (Survival of these = 55%) • 68 no ROSC • 5/68 transported with CPR (Autopulse) • 63 declared deceased at scene
  • 10. Refractory Arrest – No ambulance transport due to: • Risk of unrestrained CPR • “Futility”
  • 11. The CHEER Trial – Pilot observational trial – Refractory cardiac arrest – No ROSC at 30 minutes • CPR mechanical to The Alfred ED • Hypothermia with IV cold saline • ECMO • Emergency • Reperfusion
  • 12. Stub D, Bernard S, Pellegrino V, et al. Refractory cardiac arrest treated with mechanical CPR, hypothermia, ECMO and early reperfusion (the CHEER Trial) Resuscitation 2015; 86:88-94
  • 13.
  • 14. HERALD SUN 2/9/16 THE MAN DOCTORS BROUGHT BACK TO LIFE AFTER BEING DEAD FOR 73 MINUTES A MELBOURNE man has been brought back to life after spending a staggering 73 minutes clinically dead. Robert Kinderman has praised his survival as a miracle, while his stunned doctors at The Alfred hospital say his remarkable case redefines what is possible for cardiac arrest patients around the world.
  • 15.
  • 17. Non-ECPR treatments for refractory cardiac arrest Mechanical CPR to cardiac catheterisation laboratory? New anti-arrhythmics? Wagner H, et al. Cardiac arrest in the catheterisation laboratory: a 5-year experience of using mechanical chest compressions to facilitate PCI during prolonged resuscitation efforts. Resuscitation 2010; 81:383-7 3. Driver BE, et al. Use of esmolol after failure of standard cardiopulmonary resuscitation to treat patients with refractory ventricular fibrillation. Resuscitation 2014; 85:1337-41
  • 18.
  • 19. Refractory Arrest: “CHEER2” Clinical Practice Guideline Commenced 8/10/15 29 LUCAS2™ CPR machines for transport to metro ED for ECMO or Cath lab
  • 20.
  • 21.
  • 22. Refractory Arrest in Rural: Autopulse™ in rural Victoria for “extra pair of hands” 14 Units available Issues about fitting in car ?Transport to ED ?Transport by HEMS