This document discusses the need for a One Health approach to address pandemics and zoonotic diseases at their human-animal-environment interface. It outlines seven major drivers of zoonotic disease emergence, including increased demand for animal protein and unsustainable agricultural intensification. At least one billion people are impacted by endemic livestock diseases each year. A One Health approach is necessary to prepare for, detect, prevent, and respond to pandemics and endemics through coordinated action and investment in health systems from the local to global levels. Science also has an important role to play in understanding disease transmission and developing universal vaccines.