Keregen

1.
Jemma Gatliff
Future Health Summit
Dublin, May 2016

2.
• Overview of Keregen Therapeutics
• Our Journey
• Accelerator programs
• Aligning with academia

3. àUK-based early stage drug discovery and
àdevelopment company
àUCL School of Pharmacy Start-up/Future Spin-out
àFounded in 2015
àOperating out of UCL/Stevenage Bioscience Catalyst
Keregen Therapeutics:

4. GEOFF WELLS, Chair of SAB
Management Team
JEMMA GATLIFF, CEO NICK GEORGAKOPOULOS, CSO
Industry Advisors
ILAN ZIPKIN
Takeda Ventures Inc.
SAM FAZELI
Bloomberg
ANDY SANDHAM
Bicycle Therapeutics/ 14M Genomics
KEITH POWELL
Canbex Therapeutics
ROD PORTER
Rod Porter Consulting
Scientific Partners
ALBENA DINKOVA-KOSTOVA
University of Dundee
BIRGITT SCHUELE
Parkinson’s Institute, CA
JEFF JOHNSON
University of Wisconsin
KENNETH SMITH
Institute of Neurology, UCL
TILO KUNATH
University of Edinburgh

5. àFirst-in-class non-covalent small
àmolecule Nrf2 activators
àDisease modifying therapeutic
àintervention in Parkinson’s
àSafety profile – better or equal to
àmarketed symptomatic therapy
àOral once daily route of
àadministration
Target Product Profile:

6. Developing precision medicines for patients with
high unmet clinical need
PATIENT FOCUS
• More than five million
people worldwide have
Parkinson’s Disease
• Long-term progressive
illness
• No disease-modifying
treatments
MULTIDISCIPLINARY UNIT
• Structure-based drug
design to proof-of-
concept biological
validation
R&D DRIVERS
• Targets with genetic
evidence are more
successful in drug
discovery

7.
• Overview of Keregen Therapeutics
• Our Journey
• Accelerator programs
• Aligning with academia

8. The journey so far…
2012/13:
Nick
begins
PhD
with
Geoff.
Jemma
meets
Nick
2014:
Enter
OneStart
Feb
–
May
15:
Mentoring
from
Ilan
Zipkin
and
others
from
OneStart
May
15:
Winners
of
OneStart
£100k
prize
Oct
16
Full-­‐Sme
Keregen
Jan
16
–
Early
for
market
à
Falls
outside
typical
TTO
model
à
UCL/SBC
incubator
March-­‐April
16:
4
new
FTEs
Dec
16
–
Keregen
Incorporated
May
16:
Move
to
SBC

9. Accelerator Programs
BUILD A NETWORK
• Advisors and champions
are essential
• Get advice from
experienced people
• It takes many people to
build a company e.g.
finance, legal, scientists,
HR
LEARN THE LINGO
• Equip yourself with
business terminology
• Understand the market
opportunity
• Where does your
product fit in?
PITCH PERFECT
• Develop your business
plan
• 1 min, 3 min, 5 min, 20
min pitches

10. Aligning with academia early on
WORK SPACE
• Universities have start-
up space e.g. UCL &
Cambridge @ SBC
• Access to equipment
• Existing infrastructure
RECRUITING GROUND
• Stay in the loop with
academic research
• Highly skilled personnel
on your door step
MAXIMISE
• Non-dilutive funding
opportunities
• Collaborative projects:
continued pipeline