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Mandibular
anaesthesia
19 October 2017
I.Kassem,BDS,MSc,MFDS RCS Ed,MOMS RCPS Glasg,
FDSRCS
Consultant Oral & Maxillofacial surgeon
Mandibular Anesthesia
Lower success rate than Maxillary
anesthesia - approx. 80-85 %
Related to bone density
Less access to nerve trunks  
Mandibular Nerve Blocks
Inferior alveolar
Mental - Incisive
Buccal
Lingual
Gow-Gates
Akinosi
Mandibular Anesthesia
Most commonly performed technique
Has highest failure rate (15-20%)
Success depends on depositing solution within 1 mm of
nerve trunk
Inferior Alveolar Nerve Block
Not a complete mandibular nerve block.
Requires supplemental buccal nerve block
May require infiltration of incisors or
mesial root of first molar
Inferior Alveolar Nerve Block
Nerves anesthetized
Inferior Alveolar
Mental
Incisive
Lingual
Inferior Alveolar Nerve Block
Areas Anesthetized
Mandibular teeth to midline
Body of mandible, inferior ramus
Buccal mucosa anterior to mental foramen
Anterior 2/3 tongue & floor of mouth
Lingual soft tissue and periosteum
Inferior Alveolar Nerve Block
Indications
Multiple mandibular teeth
Buccal anterior soft tissue
Lingual anesthesia
Inferior Alveolar Nerve Block
Contraindications
Infection/inflammation at injection site
Patients at risk for self injury (eg.
children)
Inferior Alveolar Nerve Block
10%-15% positive aspiration
Inferior Alveolar Nerve Block
Alternatives
Mental nerve block
Incisive nerve block
Anterior infiltration
Inferior Alveolar Nerve Block
Alternatives (cont.)
Periodontal ligament injection (PDL)
Gow-Gates
Akinosi
Intraseptal
Inferior Alveolar Nerve Block
Technique
Apply topical
Area of insertion:
medial ramus, mid-coronoid notch,
level with occlusal plane (1 cm above),
3/4 posterior from coronoid notch to
pterygomandibular raphe
advance to bone (20-25 mm)
Inferior Alveolar Nerve Block
Target Area
Inferior alveolar nerve, near mandibular foramen
Landmarks
Coronoid notch
Pterygomandibular raphe
Occlusal plane of mandibular posteriors
Inferior Alveolar Nerve Block
Precautions
Do not inject if bone not contacted
Avoid forceful bone contact
Inferior Alveolar Nerve Block
Complications
Hematoma
Trismus
Facial paralysis
a) Halstead method
b) Gow-Gates method
c) Akinosi method
1. Inferior Alveolar Nerve Block
a) Individual variations in the locations of the
mandibular foramen
b) Be aware of the proximal extremity of the
maxillary artery. Aspiration !
a) The finger in the retromolar fossa with the
fingernail poiting backward
a) A line is sighted from occlusal surfaces of the
premolars of the opposite side to the midpoint of
the fingernail
b) Inject 0,5 - 1ml solution
c) Continue to inject 0,5ml on removal from
injection site to anesthetize the lingual branch
a) Halstead Open-Mouth method
a) Inject remaining anesthetic into coronoid notch
region in the mucous membrane distal and buccal
to most distal molar to perform a long buccal
nerve block
a) Field block anesthesia
b) The injection site is higher than Halstead
c) Below the insertion of the lateral pterygoid
muscle at the anterior side of the condyle at
maximal opening in relatively avascular area
d) The injection line is parralel with the external
line from the intertragal notch to the angle of the
mouth
b) Gow-Gates method
a) The diffusion of the anesthetic solution reach all
three oral sensory portion of mandibular branch
V.n. and other sensory nerves in this region
b) High success rate, fewer complication x slower
rate of onset
a) Field block anesthesia
b) For patient with limited opening due trismus,
ankylosis, fracture
The gingival margin above the maxillary 2nd and
3rd molars and the pterygomandibular raphae
serve as landmarks for this technique
c) Vazirani-Akinosi
closed mouth method
a) The needle is advanced through the mucous
membrane and buccinator muscle to enter the
pterygomandibular space
b) Penetrate to a depht 25mm
a) Remaining
anesthetic in long
buccal nerve area
2. Mental Nerve Block
a) Terminal branch of the inferior alveolar
nerve, exits the mandible via the mental
foramen
b) The position of this foramen is most
frequently near the apex of the mandibular 2nd
premolar
c) The foramen open upward and slightly
posteriorly!
a) Anesthetized lower lip, chin, labial gingiva,
alveolar mucosa, pulpal/periodontal tissue for the
canine, incisors and premolars on side blocked
Technique
The tip of needle be directed or anterior to
approximate the position of the foramen, but not
enter the foramen !
Penetrate to a depth 5 mm, inject 0,5 - 1,0 ml
To provide incisive nerve anesthesia via the
application of finger pressure over the foramen
after local anesthetic solution is deposited there
Mental nerve
3. Lingual Nerve Block
a) Nerve passes from the infratemporal fossa into
the floor of the mouth, in the vicinity of the 2nd and
3rd molars, is quite vulnerable
b) Is anesthetizes during the inferior alveolar
nerve block or with a bolus of anesthetic solution
injected after an inferior alveolar nerve block
a) Anesthetized anterior ⅔ of the tongue, lingual
gingiva and adjacent mucosa
Lingual nerve
4. Buccal Nerve Block
a) Arises in the infratemporal fossa and crosses
the anterior border of the ramus to give multiple
branches
b) Supplies buccal gingiva and mucosa of the
mandible for a variable length, from the vicinity of
the 3th molar to the canine
Technique - anterior ramus of the mandible at the
level of the mandibular molar occlusal plane in
the vicinity of the retromolar fossa
Buccal
nerve
Lingual
nerve
Inferior
alveolar
nerve
Mental
nerve
Reported Reasons for Mandibular
Anaesthesia Failure
1. Operator Inexperience
2. Armamentarium: Deflection of the needle tip
3. Patient factors:
1. Variations in anatomy
2. Accessory innervation
3. Unpredictable spread of LA
4. Local infection
5. Pulpal inflammation
6. Psychological issues
Reported Reasons for Mandibular
Anaesthesia Failure
1. Operator Inexperience
2. Armamentarium: Deflection of the needle tip
3. Patient factors:
1. Variations in anatomy
2. Accessory innervation
3. Unpredictable spread of LA
4. Local infection
5. Pulpal inflammation
6. Psychological issues
■ What about experienced operators?
Reported Reasons for Mandibular
Anaesthesia Failure
1. Operator Inexperience
2. Armamentarium: Deflection of the needle tip
3. Patient factors:
1. Variations in anatomy
2. Accessory innervation
3. Unpredictable spread of LA
4. Local infection
5. Pulpal inflammation
6. Psychological issues
■ Always use a long 25 gauge needle (the red
one)
■ 2 reasons:
■ 1. Less deflection
■ 2. Less false negative aspiration
Reported Reasons for Mandibular
Anaesthesia Failure
1. Operator Inexperience
2. Armamentarium: Deflection of the needle tip
3. Patient factors:
1. Variations in anatomy
2. Accessory innervation
3. Unpredictable spread of LA
4. Local infection
5. Pulpal inflammation
6. Psychological issues
Reported Reasons for Mandibular
Anaesthesia Failure
1. Operator Inexperience
2. Armamentarium: Deflection of the needle tip
3. Patient factors:
1. Variations in anatomy
2. Accessory innervation
3. Unpredictable spread of LA
4. Local infection
5. Pulpal inflammation
6. Psychological issues
Nerve to mylohyoid
Reported Reasons for Mandibular
Anaesthesia Failure
1. Operator Inexperience
2. Armamentarium: Deflection of the needle tip
3. Patient factors:
1. Variations in anatomy
2. Accessory innervation
3. Unpredictable spread of LA
4. Local infection
5. Pulpal inflammation
6. Psychological issues
Reported Reasons for Mandibular
Anaesthesia Failure
1. Operator Inexperience
2. Armamentarium: Deflection of the needle tip
3. Patient factors:
1. Variations in anatomy
2. Accessory innervation
3. Unpredictable spread of LA
4. Local infection
5. Pulpal inflammation
6. Psychological issues
■ Decrease in the pH locally
■ Can influence the amount of LA available in
the lipophilic form to diffuse across the
nerve membrane
■ Result is less drug interference of sodium
channels
■ Less likely to influence mandibular block
anaesthesia
Reported Reasons for Mandibular
Anaesthesia Failure
1. Operator Inexperience
2. Armamentarium: Deflection of the needle tip
3. Patient factors:
1. Variations in anatomy
2. Accessory innervation
3. Unpredictable spread of LA
4. Local infection
5. Pulpal inflammation
6. Psychological issues
Pulpal Inflammation
■ Causes activation and sensitization of
peripheral nociceptors
■ Causes sprouting of nerve terminals in the
pulp
■ Causes expression of different sodium
channels: TTX-resistant class of sodium
channels are 4 times as resistant to blockade
by lidocaine and their expression is doubled
in the presence of PGE2
Adjunctive Strategies
■ Additional Anaesthetic
■ PDL Injection
■ Intraosseous Injection
■ Intrapulpal Injection
■ Different anaesthetic
■ Retest using the CC
Adjunctive Strategies
■ Additional Anaesthetic
■ Higher injection
■ Gow Gates
■ Akinosi
■ Nerve to mylohyoid
■ PDL Injection
■ Intraosseous Injection
■ Intrapulpal Injection
■ Different anaesthetic
Maximum Doses LA
■ % means g/dL
■ Example:
■ 1% = 1 g/dL
■ 1% = 10g/L
■ 1% = 10 mg/mL
■ Therefore:
■ 2% = 20 mg/mL
Maximum Doses LA
■ A cartridge contains 1.8 mL
■ Therefore a cartridge of 2% local anaesthetic
contains 20 mg/mL X 1.8 mL = 36 mg of
local anaesthetic
Maximum Doses LA
■ How much LA can you give?
■ 193 lb 33 yo male
■ Lidocaine 2% 1:100K
■ Articaine 4% 1:200K
■ 2.2 lbs = 1 kg
■ 193 lbs = 88 kg
Maximum Doses LA
■ Lidocaine 2%
■ Max dose = 7 mg/kg
■ 7mg/kg X 88=616 mg
■ 36 mg/1.8 mL
■ 616mg/36mg/cart.=
■ 17 cartridges **
■ Articaine 4%
■ Max dose 7 mg/kg
■ 7 X 88 = 616 mg
■ 72 mg/1.8mL
■ 616 mg/72 mg/cart. =
■ 9 cartridges
Maximum Doses Epi
■ % = 1/100 = g/dL
■ Therefore:
■ 1/100 = 1% = 1g/dL = 10 mg/mL
■ 1/1000 = 0.1% = 0.1 g/dL = 1 mg/mL
■ 1/10000 = 0.01% = 0.01 g/dL = 0.1 mg/mL
■ 1/100000 = 0.001% = 0.001 g/dL = 0.01mg/mL
■ A cartridge contains 1.8 mL
■ Therefore a cartridge of 1:100 000 epi contains 0.01
mg/mL X 1.8 mL = 0.018 mg
(or about 0.02 mg)
Maximum Doses Epi
■ Cardiovascular patient 0.04 mg
■ Healthy patient 0.2 mg
Maximum Doses LA
■ Lidocaine 2%
■ Max dose = 7 mg/kg
■ 7mg/kg X 88=616 mg
■ 36 mg/1.8 mL
■ 616mg/36mg/cart.=
■ 17 cartridges **
■ 10-11 cartridges (epi)
■ Articaine 4%
■ Max dose 7 mg/kg
■ 7 X 88 = 616 mg
■ 72 mg/1.8mL
■ 616 mg/72 mg/cart. =
■ 9 cartridges
Pregnant Patients
■ Which Local Anaesthetic to use?
■ Articaine 4% 1:200 000 epi
■ Lidocaine 2% 1:100 000 epi
■ Mepivacaine 2% 1:20 000 levo
■ Mepivacaine 3% plain
FDA categories (based on risk of fetal
injury)
■ A: controlled studies in humans—no risk to
fetus demonstrated
■ B: animal studies show no risk, no human
studies; or animal studies have shown a risk
but human studies have shown no risk
■ C: animal studies show risk, no human
studies; or no animal or human studies
Pregnant Patients
■ Which Local Anaesthetic to use?
■ Articaine 4% 1:200 000 FDA category C
■ Lidocaine 2% 1:100 000 FDA category B
■ Mepivacaine 2% 1:20 000 FDA category C
■ Mepivacaine 3% plain FDA category C
Advantages of Injecting “Higher”
■ Failure to achieve profound local anaesthesia
attributed to being “too low” and “too far
forward”
■ Injecting superiorly and more distally may
block accessory innervation
■ 3 nodes of Ranvier may not be true
Gow-Gates Technique
■ Landmarks:
■ Corner of the mouth (contralateral side)
■ Tragus of the ear
■ Disto palatal cusp of the maxillary second molar
■ AIMING FOR THE NECK OF THE CONDYLE
Akinosi Technique
■ Closed-mouth technique
■ Does not rely on a hard-tissue landmark
■ Parallel to occlusal plane, height of the
mucogingival junction
■ Advanced until hub is level with distal surface
of maxillary second molar
■ Delayed onset of anaesthesia
Nerve to Mylohyoid
■ Deposit ¼ cartridge of LA on lingual surface
of tooth in alveolar mucosa
■ Goal is to bathe the nerve as branches of it
enter the lingual surface of the mandible
Adjunctive Strategies
■ Additional Anaesthetic
■ PDL Injection
■ Intraosseous Injection
■ Intrapulpal Injection
■ Different anaesthetic
PDL Injection
■ Technique:
■ needle inserted into the gingival sulcus at a 30
degree angle towards the tooth
■ bevel placed towards bone
■ advanced until resistance felt
■ anaesthetic injected with continuous force for
about 15 seconds.
■ approx. 0.2 mL of solution
■ 25 vs. 30 gauge needle
Adjunctive Strategies
■ Additional Anaesthetic
■ PDL Injection
■ Intraosseous Injection
■ Intrapulpal Injection
■ Different anaesthetic
Intraosseous Injection
■ Technique for mandibular infiltration
■ Perforate the cortical plate to introduce LA in
medullary bone
■ Bathes the periradicular region in LA
■ 2 commercial systems available:
■ Stabident (Patterson)
■ X-Tip (Tulsa Dentsply)
Stabident
Stabident
Stabident
Stabident
X-Tip
Adjunctive Strategies
■ Additional Block (higher injection)
■ PDL Injection
■ Intraosseous Injection
■ Intrapulpal Injection
■ Different anaesthetic
Intrapulpal Anaesthesia
■ VanGheluwe and Walton 1997:
■ under back-pressure, efficacy of LA=saline
injection
■ Conclusion: back-pressure is the key to
intrapulpal anaesthetic success
Adjunctive Strategies
■ Additional Anaesthetic
■ PDL Injection
■ Intraosseous Injection
■ Intrapulpal Injection
■ Different anaesthetic
Articaine
■ Reputation for improved local anaesthetic
effect—short linear molecule
■ Amide local, contains a thiophene ring
instead of a benzene ring
■ Partial hydrolysis by plasma esterases
■ 4% solution—concern with toxicity
■ Potential for methemoglobinemia (like
prilocaine)
Articaine
■ More effective than other local anaesthetics?
■ No difference found:
■ Haas et al. 1990 (vs. prilocaine)
■ Vahatalo et al. 1993 (vs. lidocaine)
■ Malamed et al. 2000 (vs. lidocaine)
■ Donaldson et al. 2000 (vs. prilocaine)
■ Claffey et al. 2004 (vs. lidocaine)
■ Mikesell et al. 2005 (vs. lidocaine)
Articaine
■ Claffey et al. 2004:
■ Articaine vs. lidocaine IANB for irreversible pulpitis
of mandibular teeth
■ Articaine 9/37 (24%)
■ Lidocaine 8/35 (23%)
■ (all subjects had subjective lip anaesthesia)
Articaine
■ Paraesthesia?
■ Haas and Lennon 1995: higher incidence of
paraesthesia associated with prilocaine and
articaine. Attributed to the higher concentration of
drug required for comparable clinical effect
■ 14/11 000 000 injections
■ Statistically higher
■ Clinical relevance? Claffey et al 2004 “clinically rare
event”
Articaine
■ Paraesthesia?
■ Dower 2003 (Dentistry Today)
■ Review article
■ Paraesthesia rates up to 2-4% when using
articaine for lingual blocks or IANBs
Articaine
■ Hillerup and Jensen 2006:
■ Danish population—all cases in Denmark referred
to authors for evaluation
■ 54 injection injuries in 52 patients
■ 54% of all nerve injuries associated with articaine
■ Substantial increase in number of injection injuries
following introduction of articaine to Danish market
in 2000.
Articaine
■ What about a mandibular infiltration?
■ Recommended by Steve Buchanan
■ Kanaa et al. 2006
■ Cross-over design comparing articaine and
lidocaine for mandibular infiltration for first molars
■ Anaesthesia measured by maximal EPT X2
■ Lidocaine 38% effective
■ Articaine 65% effective
Reported Reasons for Mandibular
Anaesthesia Failure
1. Operator Inexperience
2. Armamentarium: Deflection of the needle tip
3. Patient factors:
1. Variations in anatomy
2. Accessory innervation
3. Unpredictable spread of LA
4. Local infection
5. Pulpal inflammation
6. Psychological issues
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Mandibular anesthesia techniques

  • 1. Mandibular anaesthesia 19 October 2017 I.Kassem,BDS,MSc,MFDS RCS Ed,MOMS RCPS Glasg, FDSRCS Consultant Oral & Maxillofacial surgeon
  • 2. Mandibular Anesthesia Lower success rate than Maxillary anesthesia - approx. 80-85 % Related to bone density Less access to nerve trunks  
  • 3. Mandibular Nerve Blocks Inferior alveolar Mental - Incisive Buccal Lingual Gow-Gates Akinosi
  • 4. Mandibular Anesthesia Most commonly performed technique Has highest failure rate (15-20%) Success depends on depositing solution within 1 mm of nerve trunk
  • 5. Inferior Alveolar Nerve Block Not a complete mandibular nerve block. Requires supplemental buccal nerve block May require infiltration of incisors or mesial root of first molar
  • 6. Inferior Alveolar Nerve Block Nerves anesthetized Inferior Alveolar Mental Incisive Lingual
  • 7. Inferior Alveolar Nerve Block Areas Anesthetized Mandibular teeth to midline Body of mandible, inferior ramus Buccal mucosa anterior to mental foramen Anterior 2/3 tongue & floor of mouth Lingual soft tissue and periosteum
  • 8. Inferior Alveolar Nerve Block Indications Multiple mandibular teeth Buccal anterior soft tissue Lingual anesthesia
  • 9. Inferior Alveolar Nerve Block Contraindications Infection/inflammation at injection site Patients at risk for self injury (eg. children)
  • 10. Inferior Alveolar Nerve Block 10%-15% positive aspiration
  • 11. Inferior Alveolar Nerve Block Alternatives Mental nerve block Incisive nerve block Anterior infiltration
  • 12. Inferior Alveolar Nerve Block Alternatives (cont.) Periodontal ligament injection (PDL) Gow-Gates Akinosi Intraseptal
  • 13. Inferior Alveolar Nerve Block Technique Apply topical Area of insertion: medial ramus, mid-coronoid notch, level with occlusal plane (1 cm above), 3/4 posterior from coronoid notch to pterygomandibular raphe advance to bone (20-25 mm)
  • 14. Inferior Alveolar Nerve Block Target Area Inferior alveolar nerve, near mandibular foramen Landmarks Coronoid notch Pterygomandibular raphe Occlusal plane of mandibular posteriors
  • 15. Inferior Alveolar Nerve Block Precautions Do not inject if bone not contacted Avoid forceful bone contact
  • 16. Inferior Alveolar Nerve Block Complications Hematoma Trismus Facial paralysis
  • 17.
  • 18.
  • 19.
  • 20.
  • 21.
  • 22.
  • 23. a) Halstead method b) Gow-Gates method c) Akinosi method 1. Inferior Alveolar Nerve Block a) Individual variations in the locations of the mandibular foramen b) Be aware of the proximal extremity of the maxillary artery. Aspiration !
  • 24. a) The finger in the retromolar fossa with the fingernail poiting backward a) A line is sighted from occlusal surfaces of the premolars of the opposite side to the midpoint of the fingernail b) Inject 0,5 - 1ml solution c) Continue to inject 0,5ml on removal from injection site to anesthetize the lingual branch a) Halstead Open-Mouth method
  • 25.
  • 26. a) Inject remaining anesthetic into coronoid notch region in the mucous membrane distal and buccal to most distal molar to perform a long buccal nerve block
  • 27. a) Field block anesthesia b) The injection site is higher than Halstead c) Below the insertion of the lateral pterygoid muscle at the anterior side of the condyle at maximal opening in relatively avascular area d) The injection line is parralel with the external line from the intertragal notch to the angle of the mouth b) Gow-Gates method
  • 28. a) The diffusion of the anesthetic solution reach all three oral sensory portion of mandibular branch V.n. and other sensory nerves in this region b) High success rate, fewer complication x slower rate of onset
  • 29.
  • 30. a) Field block anesthesia b) For patient with limited opening due trismus, ankylosis, fracture The gingival margin above the maxillary 2nd and 3rd molars and the pterygomandibular raphae serve as landmarks for this technique c) Vazirani-Akinosi closed mouth method
  • 31. a) The needle is advanced through the mucous membrane and buccinator muscle to enter the pterygomandibular space b) Penetrate to a depht 25mm a) Remaining anesthetic in long buccal nerve area
  • 32. 2. Mental Nerve Block a) Terminal branch of the inferior alveolar nerve, exits the mandible via the mental foramen b) The position of this foramen is most frequently near the apex of the mandibular 2nd premolar c) The foramen open upward and slightly posteriorly!
  • 33. a) Anesthetized lower lip, chin, labial gingiva, alveolar mucosa, pulpal/periodontal tissue for the canine, incisors and premolars on side blocked Technique The tip of needle be directed or anterior to approximate the position of the foramen, but not enter the foramen ! Penetrate to a depth 5 mm, inject 0,5 - 1,0 ml To provide incisive nerve anesthesia via the application of finger pressure over the foramen after local anesthetic solution is deposited there
  • 35.
  • 36. 3. Lingual Nerve Block a) Nerve passes from the infratemporal fossa into the floor of the mouth, in the vicinity of the 2nd and 3rd molars, is quite vulnerable b) Is anesthetizes during the inferior alveolar nerve block or with a bolus of anesthetic solution injected after an inferior alveolar nerve block a) Anesthetized anterior ⅔ of the tongue, lingual gingiva and adjacent mucosa
  • 38. 4. Buccal Nerve Block a) Arises in the infratemporal fossa and crosses the anterior border of the ramus to give multiple branches b) Supplies buccal gingiva and mucosa of the mandible for a variable length, from the vicinity of the 3th molar to the canine
  • 39. Technique - anterior ramus of the mandible at the level of the mandibular molar occlusal plane in the vicinity of the retromolar fossa
  • 41.
  • 42. Reported Reasons for Mandibular Anaesthesia Failure 1. Operator Inexperience 2. Armamentarium: Deflection of the needle tip 3. Patient factors: 1. Variations in anatomy 2. Accessory innervation 3. Unpredictable spread of LA 4. Local infection 5. Pulpal inflammation 6. Psychological issues
  • 43. Reported Reasons for Mandibular Anaesthesia Failure 1. Operator Inexperience 2. Armamentarium: Deflection of the needle tip 3. Patient factors: 1. Variations in anatomy 2. Accessory innervation 3. Unpredictable spread of LA 4. Local infection 5. Pulpal inflammation 6. Psychological issues
  • 44. ■ What about experienced operators?
  • 45. Reported Reasons for Mandibular Anaesthesia Failure 1. Operator Inexperience 2. Armamentarium: Deflection of the needle tip 3. Patient factors: 1. Variations in anatomy 2. Accessory innervation 3. Unpredictable spread of LA 4. Local infection 5. Pulpal inflammation 6. Psychological issues
  • 46. ■ Always use a long 25 gauge needle (the red one) ■ 2 reasons: ■ 1. Less deflection ■ 2. Less false negative aspiration
  • 47. Reported Reasons for Mandibular Anaesthesia Failure 1. Operator Inexperience 2. Armamentarium: Deflection of the needle tip 3. Patient factors: 1. Variations in anatomy 2. Accessory innervation 3. Unpredictable spread of LA 4. Local infection 5. Pulpal inflammation 6. Psychological issues
  • 48.
  • 49.
  • 50. Reported Reasons for Mandibular Anaesthesia Failure 1. Operator Inexperience 2. Armamentarium: Deflection of the needle tip 3. Patient factors: 1. Variations in anatomy 2. Accessory innervation 3. Unpredictable spread of LA 4. Local infection 5. Pulpal inflammation 6. Psychological issues
  • 52. Reported Reasons for Mandibular Anaesthesia Failure 1. Operator Inexperience 2. Armamentarium: Deflection of the needle tip 3. Patient factors: 1. Variations in anatomy 2. Accessory innervation 3. Unpredictable spread of LA 4. Local infection 5. Pulpal inflammation 6. Psychological issues
  • 53. Reported Reasons for Mandibular Anaesthesia Failure 1. Operator Inexperience 2. Armamentarium: Deflection of the needle tip 3. Patient factors: 1. Variations in anatomy 2. Accessory innervation 3. Unpredictable spread of LA 4. Local infection 5. Pulpal inflammation 6. Psychological issues
  • 54. ■ Decrease in the pH locally ■ Can influence the amount of LA available in the lipophilic form to diffuse across the nerve membrane ■ Result is less drug interference of sodium channels ■ Less likely to influence mandibular block anaesthesia
  • 55. Reported Reasons for Mandibular Anaesthesia Failure 1. Operator Inexperience 2. Armamentarium: Deflection of the needle tip 3. Patient factors: 1. Variations in anatomy 2. Accessory innervation 3. Unpredictable spread of LA 4. Local infection 5. Pulpal inflammation 6. Psychological issues
  • 56. Pulpal Inflammation ■ Causes activation and sensitization of peripheral nociceptors ■ Causes sprouting of nerve terminals in the pulp ■ Causes expression of different sodium channels: TTX-resistant class of sodium channels are 4 times as resistant to blockade by lidocaine and their expression is doubled in the presence of PGE2
  • 57. Adjunctive Strategies ■ Additional Anaesthetic ■ PDL Injection ■ Intraosseous Injection ■ Intrapulpal Injection ■ Different anaesthetic ■ Retest using the CC
  • 58. Adjunctive Strategies ■ Additional Anaesthetic ■ Higher injection ■ Gow Gates ■ Akinosi ■ Nerve to mylohyoid ■ PDL Injection ■ Intraosseous Injection ■ Intrapulpal Injection ■ Different anaesthetic
  • 59.
  • 60. Maximum Doses LA ■ % means g/dL ■ Example: ■ 1% = 1 g/dL ■ 1% = 10g/L ■ 1% = 10 mg/mL ■ Therefore: ■ 2% = 20 mg/mL
  • 61. Maximum Doses LA ■ A cartridge contains 1.8 mL ■ Therefore a cartridge of 2% local anaesthetic contains 20 mg/mL X 1.8 mL = 36 mg of local anaesthetic
  • 62. Maximum Doses LA ■ How much LA can you give? ■ 193 lb 33 yo male ■ Lidocaine 2% 1:100K ■ Articaine 4% 1:200K ■ 2.2 lbs = 1 kg ■ 193 lbs = 88 kg
  • 63. Maximum Doses LA ■ Lidocaine 2% ■ Max dose = 7 mg/kg ■ 7mg/kg X 88=616 mg ■ 36 mg/1.8 mL ■ 616mg/36mg/cart.= ■ 17 cartridges ** ■ Articaine 4% ■ Max dose 7 mg/kg ■ 7 X 88 = 616 mg ■ 72 mg/1.8mL ■ 616 mg/72 mg/cart. = ■ 9 cartridges
  • 64. Maximum Doses Epi ■ % = 1/100 = g/dL ■ Therefore: ■ 1/100 = 1% = 1g/dL = 10 mg/mL ■ 1/1000 = 0.1% = 0.1 g/dL = 1 mg/mL ■ 1/10000 = 0.01% = 0.01 g/dL = 0.1 mg/mL ■ 1/100000 = 0.001% = 0.001 g/dL = 0.01mg/mL ■ A cartridge contains 1.8 mL ■ Therefore a cartridge of 1:100 000 epi contains 0.01 mg/mL X 1.8 mL = 0.018 mg (or about 0.02 mg)
  • 65. Maximum Doses Epi ■ Cardiovascular patient 0.04 mg ■ Healthy patient 0.2 mg
  • 66. Maximum Doses LA ■ Lidocaine 2% ■ Max dose = 7 mg/kg ■ 7mg/kg X 88=616 mg ■ 36 mg/1.8 mL ■ 616mg/36mg/cart.= ■ 17 cartridges ** ■ 10-11 cartridges (epi) ■ Articaine 4% ■ Max dose 7 mg/kg ■ 7 X 88 = 616 mg ■ 72 mg/1.8mL ■ 616 mg/72 mg/cart. = ■ 9 cartridges
  • 67.
  • 68. Pregnant Patients ■ Which Local Anaesthetic to use? ■ Articaine 4% 1:200 000 epi ■ Lidocaine 2% 1:100 000 epi ■ Mepivacaine 2% 1:20 000 levo ■ Mepivacaine 3% plain
  • 69. FDA categories (based on risk of fetal injury) ■ A: controlled studies in humans—no risk to fetus demonstrated ■ B: animal studies show no risk, no human studies; or animal studies have shown a risk but human studies have shown no risk ■ C: animal studies show risk, no human studies; or no animal or human studies
  • 70. Pregnant Patients ■ Which Local Anaesthetic to use? ■ Articaine 4% 1:200 000 FDA category C ■ Lidocaine 2% 1:100 000 FDA category B ■ Mepivacaine 2% 1:20 000 FDA category C ■ Mepivacaine 3% plain FDA category C
  • 71. Advantages of Injecting “Higher” ■ Failure to achieve profound local anaesthesia attributed to being “too low” and “too far forward” ■ Injecting superiorly and more distally may block accessory innervation ■ 3 nodes of Ranvier may not be true
  • 72. Gow-Gates Technique ■ Landmarks: ■ Corner of the mouth (contralateral side) ■ Tragus of the ear ■ Disto palatal cusp of the maxillary second molar ■ AIMING FOR THE NECK OF THE CONDYLE
  • 73.
  • 74.
  • 75. Akinosi Technique ■ Closed-mouth technique ■ Does not rely on a hard-tissue landmark ■ Parallel to occlusal plane, height of the mucogingival junction ■ Advanced until hub is level with distal surface of maxillary second molar ■ Delayed onset of anaesthesia
  • 76.
  • 77.
  • 78. Nerve to Mylohyoid ■ Deposit ¼ cartridge of LA on lingual surface of tooth in alveolar mucosa ■ Goal is to bathe the nerve as branches of it enter the lingual surface of the mandible
  • 79. Adjunctive Strategies ■ Additional Anaesthetic ■ PDL Injection ■ Intraosseous Injection ■ Intrapulpal Injection ■ Different anaesthetic
  • 80. PDL Injection ■ Technique: ■ needle inserted into the gingival sulcus at a 30 degree angle towards the tooth ■ bevel placed towards bone ■ advanced until resistance felt ■ anaesthetic injected with continuous force for about 15 seconds. ■ approx. 0.2 mL of solution ■ 25 vs. 30 gauge needle
  • 81.
  • 82. Adjunctive Strategies ■ Additional Anaesthetic ■ PDL Injection ■ Intraosseous Injection ■ Intrapulpal Injection ■ Different anaesthetic
  • 83. Intraosseous Injection ■ Technique for mandibular infiltration ■ Perforate the cortical plate to introduce LA in medullary bone ■ Bathes the periradicular region in LA ■ 2 commercial systems available: ■ Stabident (Patterson) ■ X-Tip (Tulsa Dentsply)
  • 88. X-Tip
  • 89. Adjunctive Strategies ■ Additional Block (higher injection) ■ PDL Injection ■ Intraosseous Injection ■ Intrapulpal Injection ■ Different anaesthetic
  • 90. Intrapulpal Anaesthesia ■ VanGheluwe and Walton 1997: ■ under back-pressure, efficacy of LA=saline injection ■ Conclusion: back-pressure is the key to intrapulpal anaesthetic success
  • 91. Adjunctive Strategies ■ Additional Anaesthetic ■ PDL Injection ■ Intraosseous Injection ■ Intrapulpal Injection ■ Different anaesthetic
  • 92.
  • 93. Articaine ■ Reputation for improved local anaesthetic effect—short linear molecule ■ Amide local, contains a thiophene ring instead of a benzene ring ■ Partial hydrolysis by plasma esterases ■ 4% solution—concern with toxicity ■ Potential for methemoglobinemia (like prilocaine)
  • 94. Articaine ■ More effective than other local anaesthetics? ■ No difference found: ■ Haas et al. 1990 (vs. prilocaine) ■ Vahatalo et al. 1993 (vs. lidocaine) ■ Malamed et al. 2000 (vs. lidocaine) ■ Donaldson et al. 2000 (vs. prilocaine) ■ Claffey et al. 2004 (vs. lidocaine) ■ Mikesell et al. 2005 (vs. lidocaine)
  • 95. Articaine ■ Claffey et al. 2004: ■ Articaine vs. lidocaine IANB for irreversible pulpitis of mandibular teeth ■ Articaine 9/37 (24%) ■ Lidocaine 8/35 (23%) ■ (all subjects had subjective lip anaesthesia)
  • 96. Articaine ■ Paraesthesia? ■ Haas and Lennon 1995: higher incidence of paraesthesia associated with prilocaine and articaine. Attributed to the higher concentration of drug required for comparable clinical effect ■ 14/11 000 000 injections ■ Statistically higher ■ Clinical relevance? Claffey et al 2004 “clinically rare event”
  • 97. Articaine ■ Paraesthesia? ■ Dower 2003 (Dentistry Today) ■ Review article ■ Paraesthesia rates up to 2-4% when using articaine for lingual blocks or IANBs
  • 98. Articaine ■ Hillerup and Jensen 2006: ■ Danish population—all cases in Denmark referred to authors for evaluation ■ 54 injection injuries in 52 patients ■ 54% of all nerve injuries associated with articaine ■ Substantial increase in number of injection injuries following introduction of articaine to Danish market in 2000.
  • 99. Articaine ■ What about a mandibular infiltration? ■ Recommended by Steve Buchanan ■ Kanaa et al. 2006 ■ Cross-over design comparing articaine and lidocaine for mandibular infiltration for first molars ■ Anaesthesia measured by maximal EPT X2 ■ Lidocaine 38% effective ■ Articaine 65% effective
  • 100. Reported Reasons for Mandibular Anaesthesia Failure 1. Operator Inexperience 2. Armamentarium: Deflection of the needle tip 3. Patient factors: 1. Variations in anatomy 2. Accessory innervation 3. Unpredictable spread of LA 4. Local infection 5. Pulpal inflammation 6. Psychological issues
  • 101. Do you need a break?