1. Bacteria Responsible for lowering Immune System in oral
Cavity informs a Michigan Dentist
A new research has revealed that bacteria known as Porphyromonas gingivalis causing
gum disease in human beings tends to manipulate the human body's immune system to an
extent that is disables normal processes. The damage is quite heavy as it prompts the
production of the anti-inflammatory molecule Interleukin-10 (IL-10). The production of
the anti-inflammatory molecule specifically inhibits the function of T-cells that would have
helped to protect the human body from this microbial infection.
Many dentists have been carrying out research in this regard and thus focus on keeping the
oral cavity clean not just by brushing and flossing but also by other means. As the human
immune system is exposed to many other pathogens thus it may be quite difficult to cure a
particular disease if the human body has already been hosting Porphyromonas gingivalis.
Apart from that the fact that 50 percent of US population over 50 years suffers from
periodontal diseases this study becomes all the more crucial as it will come handy in
deciding the course of treatment that would be taken by dentists while attending on
patients who are already infected with Porphyromonas gingivalis and then have developed
some other kind of periodontal infection.

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Scientists came to the conclusion via a series of experiments that were carried out on mice.
Cells from mice were treated with Porphyromonas gingivalis and another portion of the cells
from mice was left without being infected with Porphyromonas gingivalis. After that all cells
were tested for interferon gamma production. The cells that were infected with
Porphyromonas gingivalis were found to be have an increase in interferon gamma production
whereas no increase was found in the cells that were not infected with Porphyromonas
gingivalis.
Thus it was inferred that the damage done by Porphyromonas gingivalis was quite obvious
and immune system of the organism or organ is destroyed once it is exposed to this pathogen.
Another fact that came to light was that the treatment needs to start as early as possible to take
control of the situation. Thus Porphyromonas gingivalis can establish a chronic infection in
the form of periodontal disease.
A vaccine to stop the growth of Porphyromonas gingivalis can be developed or other
therapeutic treatments can be given to eradicate the damage done by Porphyromonas
gingivalis and save the human oral cavity from further deterioration.
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