Allergy

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KARTHIK REDDY C A

Allergy

Ciencias

Skin Allergy & Detection Tests
KKR1116 9

The in vitro diagnosis of IgE-mediated allergic diseases is useful in the
identification of the causative allergen(s) and usually involves different
laboratory procedures. In particular:
•The total IgE assay which is nonspecific and provides only gross
information.
•Serum specific IgE assays against allergen sources/molecules are the most
commonly used in vitro diagnostic approach. They can be performed by a
singleplexed or multiplexed strategy.
•The Basophil Activation Test (BAT) which is quite specific, but complex to
perform, and therefore limited to selected situations.
KKR1116 24

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Context. WASP-76 b has been a recurrent subject of study since the detection of a signature in high-resolution transit spectroscopy data indicating an asymmetry between the two limbs of the planet. The existence of this asymmetric signature has been confirmed by multiple studies, but its physical origin is still under debate. In addition, it contrasts with the absence of asymmetry reported in the infrared (IR) phase curve. Aims. We provide a more comprehensive dataset of WASP-76 b with the goal of drawing a complete view of the physical processes at work in this atmosphere. In particular, we attempt to reconcile visible high-resolution transit spectroscopy data and IR broadband phase curves. Methods. We gathered 3 phase curves, 20 occultations, and 6 transits for WASP-76 b in the visible with the CHEOPS space telescope. We also report the analysis of three unpublished sectors observed by the TESS space telescope (also in the visible), which represents 34 phase curves. Results. WASP-76 b displays an occultation of 260±11 and 152±10 ppm in TESS and CHEOPS bandpasses respectively. Depending on the composition assumed for the atmosphere and the data reduction used for the IR data, we derived geometric albedo estimates that range from 0.05 ± 0.023 to 0.146 ± 0.013 and from <0.13 to 0.189 ± 0.017 in the CHEOPS and TESS bandpasses, respectively. As expected from the IR phase curves, a low-order model of the phase curves does not yield any detectable asymmetry in the visible either. However, an empirical model allowing for sharper phase curve variations offers a hint of a flux excess before the occultation, with an amplitude of ∼40 ppm, an orbital offset of ∼−30◦ , and a width of ∼20◦ . We also constrained the orbital eccentricity of WASP-76 b to a value lower than 0.0067, with a 99.7% confidence level. This result contradicts earlier proposed scenarios aimed at explaining the asymmetry observed in high-resolution transit spectroscopy. Conclusions. In light of these findings, we hypothesise that WASP-76 b could have night-side clouds that extend predominantly towards its eastern limb. At this limb, the clouds would be associated with spherical droplets or spherically shaped aerosols of an unknown species, which would be responsible for a glory effect in the visible phase curves.

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Allergy

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24. The in vitro diagnosis of IgE-mediated allergic diseases is useful in the identification of the causative allergen(s) and usually involves different laboratory procedures. In particular: •The total IgE assay which is nonspecific and provides only gross information. •Serum specific IgE assays against allergen sources/molecules are the most commonly used in vitro diagnostic approach. They can be performed by a singleplexed or multiplexed strategy. •The Basophil Activation Test (BAT) which is quite specific, but complex to perform, and therefore limited to selected situations. KKR1116 24

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