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Kopexil (Diaminopyrimidine Oxide) - A Fortifying Hair Growth Active For Hair Care Formulation
1. Kopexil
Diaminopyrimidine Oxide
A fortifying hair growth active for hair care formulation
Clinically proven to be effective
Strengthens hair from root to tip
Promotes hair thickness
Ceases hair loss
Accelerates hair growth
Reinforces hair anchoring
2. KOPEXIL increases the volume of hair in the growth stage by working on the deep structure of the roots. It rejuvenates the hair roots so that healthy hair
growth can persist. The perifollicular fibrosis is a condition in which collagen around the roots becomes rigid, tightens, and pushes the hair out; KOPEXIl helps in
softening of the collagen. KOPEXIL is used in hair cosmetics to combat hair loss due to premature exhaustion of the hair root.
Specification
Description
Chemical Name 2,4-diamino pyrimidine-3-Oxide
INCIName Diamino Pyrimidine Oxide
Trade Name Kopexil
CAS No 7438-76-9
Molecular Formula C H N O4 6 4
Harmonized Tariff No. 29335995
Regulatory Status*:
Not approved by FDA
Europe : Allowed for personal care application
USA : Allowed for personal care application
Japan : Allowed in selected product category
Rest of world : Allowed for use in most of the Asian countries
*Consult your regulatory authority for use level and restrictions.
Applications:
-Hair Oil -Hair Conditioner
-Hair Lotion -HairGel
-Hair Shampoo -Treatment for seasonal hair loss
Solubility:
a) 1gm Kopexil soluble in 30 ml water
b) 1gm Kopexil soluble in 10ml of Propylene glycol
c) 1gm Kopexil soluble in mixture of 25ml water & 5ml Ethanol
d) 1gm Kopexil soluble in mixtureof 30 ml Ethanol and 12 ml water.
The above solubility observed with sonication at RT.Generally, solubility of Kopexil is poor in all solvents.
Appearance White to off white crystalline powder
Assayby HPLC(on dried basis) 98.0-102.0%
Impurities
a. 2,4-Diaminopyrimidine
b. 2,4-Diamino 6-chloropyrimidine 3-
oxide
NMT 0.60%
NMT 0.20%
Odor Odorless
Purity by HPLC NLT 98%
Dosage Level 0.2%-1.5%
Clinical efficacy of KOPEXIL hair gel manufactured by
Kumar Organic Products Pvt Ltd in stimulating hair growth
N
NNH2 NH2
O
Pattern of increase in new hair after 6 months of treatment
Corporate Office:
KUMAR ORGANIC PRODUCTS LTD
NO# 819/C, 13th cross, 7th block (West),
Jayanagar, Bangalore-560082, Karnataka, India
TEL:91-080-41425832 FAX: 91-080-26715688
E-mail: sales@kumarorganic.net
Website: http://www.kumarorganic.net
UK office:
Kumar Organic Products Limited
41 King StreetLutonBedfordshireLU1 2DW
TEL: 0044 1582 345334 FAX: 0044 1582 724986
Email - hamitwalia_sales@kumarorganic.net,
sales_europe@kumarorganic.net
USA Office:
Kumar Organic Products limited
Suite M, ITM corporate center
6 Kilmer Road, Edison, NJ 08817
Ph-732 662 2651 Fax – 201 604 6727
Email : sunitha_sales@kumarorganic.net
Singapore Office
Kumar Organic Products limited
The Octagon 105, Cecil Street
#07-01- Centennial Business Centre Singapore
069534
PH: 00 65 6223 1321 Fax: 00 65 6532 0198
Email : kumar_singapore@kumarorganic.net
Usha Krishna Centre, 819/C, 13th Cross, 7th Block, Near JSS College Circle,
Jayanagar, Bangalore-560041, Karnataka, India
Ph:+918041425832, Fax:+918026715688, e-mail: kop@kumarorganic.net