Zinc pyrithione is best known for its use in treating dandruff and seborrhoeic dermatitis. It also has antibacterial properties and is effective against many pathogens from the Streptococcus and Staphylococcus genera. Its other medical applications include treatments of psoriasis, eczema, ringworm, fungus, athletes foot, dry skin, atopic dermatitis, tinea, and vitiligo.

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Kumar Organic Products Limited
Ingredients For Us

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Dandruff - Cause & Consequences
Dandruff, the shedding of dead skin cells from the
scalp at an excessive rate, is the result of metabolic
by products of skin micro-organisms (fungus
Malassezia furfur previously known as
Pityrosporum Ovale.
Malassezia metabolizes triglycerides present in
sebum by the expression of lipase, resulting in a
lipid byproduct Oleic Acid (OA). Penetration by OA
of the top layer of the epidermis, the results in
cleavage of the stratum corneum cells, As a result
dead skin cells are shed in large oily clumps which
appears as white or grayish patches on the scalp,
skin and clothes

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Metabolizes
Triglyceride
present in sebum
Lipid by Product
Oleic Acid
Penetrates top
layer of
epidermis
Stratum
Corneum
Dandruff
Inflammatory
Response
Malassezia
Erratic cleavage
of Stratum
Corneum cell
Dandruff - Cause & Consequences
Dandruff cause is linked with presence of higher than normal count of
lipophilic yeast –Pityrosporum Ovale ( Malassezia furfur)

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Zinc Pyrithione - Mechanism of Action
The Antifungal effect of ZINC PYRITHIONE is proposed to derive from its ability to
disrupt membrane transport by blocking the proton pump that energizes the
transport mechanism.
A. ZINC PYRITHIONE yields a soluble portion of Zinc Pyrithione molecules, which
penetrate the fungal cell membrane (green).

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Zinc Pyrithione - Mechanism of Action
B. ZINC PYRITHIONE undergoes
dissociative equilibrium which reduces
portion of the material present in the
bio-active complexed form
C. The addition of an exogenous
source of zinc ions (red) shifts the
equilibrium in the favor of the
complexed Zinc Pyrithione form,
thereby increasing delivery to the
fungal cells (red)

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Zinc Pyrithione - Clinical Study
1. Efficacy and safety study of Zinc Pyrithione shampoo against dandruff
In the clinical evaluation of 20 subjects, for a period of 4 weeks of usage of anti-dandruff
shampoo With zinc Pyrithione, none of them complained of any adverse effects like pruritis
(itching), erythema, increase in dandruff, local discomfort etc, After 4 weeks of usage of
anti-dandruff shampoo with Zinc Pyrithione, it was not possible to isolate Malassezia furfur
in culture from all volunteers. Further there was definite reduction in dandruff in all the
volunteers

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Zinc Pyrithione - Clinical Study
2. Testing of susceptibility of Malssezzia furfur to anti-dandruff shampoo with Zinc
Pyrithione
The minimum inhibitory concentration of anti-dandruff shampoo with Zinc Pyrithione
required for the total inhibition of Malassezia furfur (1X 106 cells / ml) is found to be
700 µ/ml.

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Kopthione 50% – Product Specification
Trade Name KOPTHIONE 50 % fine particle
suspension
INCI Name Zinc Pyrithione
Molecular Formula C10H8N2O2S2Zn
CAS No 13463-41-7
EINECS 236 – 671 – 3
Appearance White to off-white suspension
Assay 48 -50 %
pH 6.5 – 9.0 %
Zinc content 9.3 to 11.3 %
Solubility Water – Practically Insoluble
Caustic Soda – Soluble
Acids - Soluble
Storage Keep away from sunlight and heat

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Safety Data & Regulatory Status
Safety Data:
The acute as well as the sub-chronic toxicity was moderate to low, for both Zinc
Pyrithione alone, or incorporated in market formulations, In chronic toxicity
experiments it was shown that an oral application of 500 µg/kg/day can be regarded as
a dose that does not cause any adverse effects (NOAEL). No evidence of a
carcinogenic response was seen when Zinc Pyrithione was applied topically upto 100
mg/kg/day or given orally up to 5 mg/kg/day in lifetime studies.
Regulatory Status
USA : Approved for OTC topical use
Europe: Approved for OTC topical use
Japan : Approved for OTC topical use
Rest of the world: Approved for use in many Asian, African and South American
countries
*Consult your regulatory authority for use level and restrictions.
R.E.A.C.H: Pre-registration reference number : 05-2114092713-46-0000

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Zinc pyrithione is best known for its use in treating dandruff and seborrhoeic
dermatitis. It also has antibacterial properties and is effective against many
pathogens from the Streptococcus and Staphylococcus genera. Its other
medical applications include treatments of psoriasis, eczema, ringworm,
fungus, athletes foot, dry skin, atopic dermatitis, tinea, and vitiligo.
Packaging Sizes :
For Dispersion : 25 Kg drums
Shelf Life : Minimum 3 years from the date of manufacturing in original
sealed containers
Storage Conditions : Keep away from sunlight and heat
Dosage & Application

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Literature References:
[1] G Lorette, and V Ermosilla, Clinical efficacy of a new ciclopiroxolamine/zinc pyrithione shampoo in scalp
seborrheic dermatitis treatment, Eur J Dermatol, 16(5):558-564, 2006.
[2] E Guthery, LA Seal, and EL Anderson, Zinc Pyrithione in alcohol-based products for skin antisepsis:
Persistence of antimicrobial effects, Am J Infect Control, 33(1):15-22, 2005.
[3] KS Grunnet, and I Dahllof, Environmental fate of the antifouling compound zinc pyrithione in seawater,
Environ Toxicol Chem, 24(12):3001-3006, 2005.
[4] P Bailey, C Arrowsmith, K Darling, J Dexter, J Eklund, A Lane, C Little, B Murray, A Scott, A Williams, and
D Wilson, A double-blind randomized vehicle-controlled clinical trial investigating the effect of ZnPTO dose
on the scalp vs. antidandruff efficacy and antimycotic activity. Int J Cosmet Sci, 25(4):183-188, 2003.
[5] RS Berger, JL Fu JL, KA Smiles, CB Turner, BM Schnell, KM Werchowski, KM Lammers, The effects of
minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial, Br J
Dermatol, 149(2):354-362, 2003.
Disclaimer:
The information given and the recommendations made herein are based on literature search and are believed
to be accurate but no guarantee of their accuracy is made. Information is supplied upon the condition that the
receivers will make their own determination as to its suitability for their purposes prior to use. In no event will
KUMAR ORGANIC PRODUCTS LTD be responsible for the damage of any nature whatsoever resulting from the
use of or upon reliance of the information

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KUMAR ORGANIC PRODUCTS LIMITED
819/C, 13th Cross, 7th Block, Near JSS College Circle,
Jayanagar, Bangalore-560041. Karnataka, India.
Ph: 91 - 80 - 41425832/41525960 Ext- 153
Email : kop@kumarorganic.net