This document discusses negative trials in neurosurgery. It lists several negative trials led by Drs. Patel, Bervini, Lai, Gragnaniello, Paramasvaran, and Liu. Negative trials can be inconclusive with inadequate power/methodology or show clear evidence of no effect or harm. Reasons for negative results include issues with trial design, size, bias, analysis, and inclusion/exclusion criteria affecting generalizability. Negative studies should still be published to acknowledge participant contributions, contribute to scientific knowledge, avoid publication bias, and fulfill funding conditions. Lessons from negative trials include whether the intervention warrants further research, continued use in select populations, or should be abandoned.