How to use information in order to reduce age-related disease. The discussion includes hormesis and environmental enrichment.

1. Healthy Ageing through
Technoculture
Marios Kyriazis
ELPIs Foundation for Indefinite Lifespans
www.elpisfil.org

2. How to conquer ageing
• Biotechnology?
• Drugs and supplements?
• Nanotechnology?
• Stem cells?
• Artificial Intelligence?

3. The fallacy of the longevity elixir
PROBLEMS:
• Stem cells: harvesting, delivery, compatibility, bone marrow
transplants
• Tissue engineering: harvesting, surgical transplants
• Genetic therapies: technical issues, delivery, integration in the body
• Nano-medicine: unknown results, side effects
• Pharmacological therapies: compliance, interactions, polypharmacy

4. BIOLOGY OF AGEING
CELLS
DNA
LYSOSOMES
ABNORMAL
PROTEINS
FREE
RADICALS
MITOCHONDRIA
CROSS
LINKS

5. A wider view of ageing

6. ELIMINATION OF AGEING
BIOLOGY
EPIGENE
TICS
LIFESTYLE
REPAIR
BIOMEDICINE
REPRODUCTION
GENDER
EVOLUTION
CULTURE
ETHICS
CONFLICT
RESOLUTION
RISKS
TECHNOLOGY
HYPER
CONNECTION
GLOBAL
BRAIN
COMPLEXITY
SCIENCE
CYBERNETICS
SOCIETY
ENVIRON
MENT
SMART
CITIES
POLITICS

7. I concentrate on Technology and Culture
Technology Culture

8. Both concepts are based on
INFORMATION
A meaningful set of data or patterns which influence the formation or
transformation of other data or patterns, in order to reduce uncertainty
and help achieve a goal

9. Information
+ Complexity Functionality Fitness Survival
Organisation

10. How to increase information
content
1. Enriched environment, hormetic challenges
2. Social hyper-connectivity (real and virtual/online)
3. Behavioural models: goal-seeking behavior, search for excellence, a bias for action
4. The pursuit of innovation, diversification, creativity, novelty, and the avoidance of routine.

11. Hormesis
An adaptive response of cells and
organisms to a moderate,
intermittent, challenge.
Hormesis describes phenomena
where there is low dose
stimulation, high dose inhibition.
Nutritional, physical, mental and
chemical challenges may result in
mild damage which upregulates
repair mechanisms. In an attempt
to repair this damage, age-related
damage is also repaired.

12. Examples of hormesis
Nutritional
Physical
Sexual
Social

13. Environmental Enrichment
Experimental animals are
exposed to an enriched
environment- a habitat
augmentation. This has
several positive effects on
health, specifically on
brain and immune
function.

14. Challenge
Here, a challenge is defined as a situation that potentially carries
biological value for an organism, so that the organism is inclined to act.
A challenge provokes action because it represents a situation in which
not acting will lead to an overall lower fitness than acting.

15. The balance between age-related degeneration and health depends on:
A. How well our repair processes are maintained through artificial (item-based)
pharmacological, genetic, cellular, biotechnological and other physical interventions.
B. Through utilising challenging exposure to information with consequent
improvement of function.

16. Use of internet and longevity

17. Global Brain

18. Internet connections

19. An Irregular, Useful
Guest
Second, usefulness
• Humanity is not going to improve if its members
don't make an effort to achieve something higher.
Third, quest
• Always seek novelty, never be satisfied, never sit
quiet and 'relax' for long periods. Be inquisitive,
always ask 'why' and don't take anything at face
value.
• Try to get to the top but don't stop there. There is
always something higher.
• Come up with new ideas, and then try to achieve
them.
First, irregularity
We thrive on change, challenges
and unexpected events.
A ‘power-law’ lifestyle: frequent
low level activities, some medium
level ones, and rare intense
activities.
Ever-changing, imaginative and
unpredictable activities improve
immunity, reduce inflammation,
improve nerve-growth factors, and
many others.

20. The end?
ELPIs Foundation for Indefinite
Lifespans
www.elpisfil.org
drmarios@live.it
Meeting to discuss these concepts: 3rd
Symposium ‘Pathways to Indefinite
Lifespans’
0n Saturday 23 May 2015, In Larnaca,
Cyprus