Tx Single Use Seminar Jun09

TangenX - Sius TM Single Use Tangential Flow Filtration Cassettes Mark Perreault, TangenX Technology

TangenX TFF Membranes and Cassettes

TangenX Technology Corp.– Shrewsbury, MA ,[object Object],[object Object],[object Object],[object Object],[object Object]

TangenX Overview Ultrafiltration Membranes

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],SEM X-Section of the ProStream 100KD ,[object Object],[object Object],[object Object],[object Object],[object Object],TangenX Membranes - mPES

TangenX mPES Membranes Two (2) Membrane Chemistries ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ProStream TM 10 kD (1000X) HyStream TM 10 kD (1000X)

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ProStream 10KD HyStream 10KD TangenX Membranes - mPES (+) (-) (+) (-) (+) (-) (+) (-) (+) (-) (+) (-) (+) (-) (+) (-) ProStream (+/-) (+/-) (+/-) (+/-) (+/-) (-) (-) (-) (-) (-) (-) (-) (-) (-) (-) (-) (-) (-) (-) (-) Un-Modified PES (+) (+) (+) (+) (+) (+)

[object Object],[object Object],[object Object],[object Object],Membrane Selectivity Curves for: ProStream Membranes HyStream Membranes Contact Angle Measurement (water at 20 o C) HyStream SEM of the HyStream 0.1um surface at 20,000X Data generated in triplicate using 13cm2 stirred cells TangenX Membranes - mPES

TangenX Membranes - mPES ,[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],TangenX Membranes - mPES

100KD ProStream mPES MAb Optimization – 10mg/ml

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],TangenX Membranes - mPES

[object Object],TangenX Membranes - mPES

TangenX - Sius TM Single Use Tangential Flow Filtration Cassettes

ISPE Carolina South-Atlantic Chapter Sius TM Single-Use TFF Cassettes ,[object Object],[object Object],[object Object],[object Object],[object Object]

ISPE Carolina South-Atlantic Chapter Sius TM Single-Use TFF Cassettes

Sius TM Single-Use TFF Cassettes

[object Object],[object Object],[object Object],*patent pending Sius TM Single-Use TFF Cassettes

[object Object],[object Object],[object Object],[object Object],[object Object],Benifits – Sius TM Cassettes

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Linear Scalability – Sius TM Cassettes

“ L” Screen 1.0mm Open Channel Flow Spacers Low Viscosity High Viscosity & Particulates 0.5mm Open Channel Membrane Flow Spacers Lower Cross Flow Rate Higher Cross Flow Rate Higher Cross Flow Velocity Lower Cross Flow Velocity Channel Options – Sius TM Cassettes

[object Object],[object Object],[object Object],[object Object],Manufacturing – Sius TM Cassettes

[object Object],[object Object],Manufacturing – Sius TM Cassettes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Patent Pending

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Specifications – Sius TM Cassettes

Product Support – Validation Guide

Product Support – Product Use

[object Object],[object Object],[object Object],[object Object],[object Object],Product Support – Manufacturing

Single Use - Summary ,[object Object],[object Object],[object Object],[object Object],[object Object]

TangenX - NovaSet TM Tangential Flow Filtration Cassettes

NovaSet TM -LS Reusable TFF Cassette

NovaSet TM Reusable TFF Cassette

NovaSet TM - Feed Channel Options Low Viscosity High Viscosity & Particulates Higher Cross Flow Velocity Lower Cross Flow Velocity Lower Cross Flow Rate Higher Cross Flow Rate “ H” Screen Membrane Suspended Screen Flow Spacers “ L” Screen

NovaSet TM Reusable TFF Cassette NovaSet™ Cassette 0.5, 1.5 or 2.5m 2 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],NovaSet TM vs. Sius TM TFF Cassette Performance

[object Object],[object Object],[object Object],NovaSet TM vs. Sius TM TFF Cassette Performance

NovaSet TM vs. Sius TM TFF Cassette Performance ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

TangenX - TFF Cassette Holders for NovaSet TM and Sius TM

BioPharm TFF – Process ,[object Object],[object Object]

TangenX - Sius TM Filter Plate Insert (FPI)

[object Object],[object Object],[object Object],Disposable Flow Path for Sius TM Cassettes

System Design ,[object Object],[object Object],[object Object],System Design

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Materials of Construction

Insert Plate Features ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Insert Plate Features

[object Object],[object Object],FPI - Laboratory Scale

Options ,[object Object],[object Object],FPI - Options

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Current Status of FPI

TangenX Overview Thank You For Your Attention

Tx Single Use Seminar Jun09

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