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Chronic Urticaria and Angioedema by the Urticaria and Angioedema Committee © AAAAI 2006
Angioedema vs Urticaria ,[object Object],[object Object],[object Object],[object Object],[object Object]
Chronic Urticaria/Angioedema (Mast cell driven) Urticaria & Angioedema Urticaria Angioedema 40% 50% 10 %
 
Drug Induced Urticaria / Angioedema Bradykinin responsible for swelling in angioedema in patients with HAE   Kaplan A et al J Allergy Clin Immunol 2002;109:195-209   Angiotensin converting enzyme (ACE) inhibitors interfere with metabolism of bradykinin via interference with kininase Ii   Gavras I Kidney Int 1992; 42:1020-29 Patients on angiotensin converting enzyme blockers (ARBs) may not be at risk for angioedema   Gavras I Arch Int Med 2003; 163: 240-1
Hereditary Angioedema ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acquired Angioedema (AAE) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Aspects cliniques ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],C1 Inhibitor Functions
 
(Ecalantide)
 
 
Laboratory Tests for C1 Inhibitor Deficiency ,[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment of Hereditary Angioedema ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Presentation of Urticaria ,[object Object],[object Object],[object Object],[object Object]
Acute vs Chronic Urticaria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physical Urticarias ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Physical urticaria
Symptomatic Dermatographism ,[object Object],[object Object],[object Object],[object Object]
Cholinergic Urticaria
Cholinergic Urticaria ,[object Object],[object Object],[object Object],[object Object],[object Object],Cholinergic urticaria
Cold-Induced Urticaria ,[object Object],[object Object],[object Object],Cold-induced urticaria
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Diagnosis of cold-induced urticaria
Delayed Pressure Urticaria
Delayed Pressure Angioedema ,[object Object],[object Object],[object Object]
Vibratory  angioedema  Lawlor F  et al  Br J Dermatol  1989; 120: 93-99 Vortex to induce angioedema in a patient with swelling of hands while driving car
Solar Urticaria ,[object Object],[object Object],[object Object],[object Object],[object Object]
B Cell Lymphoma Associated with Symptomatic Dermatographism Patient’s dermatographism resistant to fexofenadine and cetirizine sent a clue that something else may be causing her itching and hives.
Hypocomplementemic Urticarial Vasculitis Syndrome (HUVS) Hypocomplementemic urticarial vasculitis syndrome ,[object Object],[object Object],[object Object],[object Object]
Antibodies associated with urticaria  IgG auto ab to IgE receptor 35-40% Antithyroglobulin Ab    8% Antimicrosomal Ab 5%
Autologous Serum   Skin Test ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Autologous serum skin test
[object Object],[object Object],[object Object],Therapeutic  options

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Hereditaryangioedema B

  • 1.  
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  • 7. Chronic Urticaria and Angioedema by the Urticaria and Angioedema Committee © AAAAI 2006
  • 8.
  • 9. Chronic Urticaria/Angioedema (Mast cell driven) Urticaria & Angioedema Urticaria Angioedema 40% 50% 10 %
  • 10.  
  • 11. Drug Induced Urticaria / Angioedema Bradykinin responsible for swelling in angioedema in patients with HAE Kaplan A et al J Allergy Clin Immunol 2002;109:195-209 Angiotensin converting enzyme (ACE) inhibitors interfere with metabolism of bradykinin via interference with kininase Ii Gavras I Kidney Int 1992; 42:1020-29 Patients on angiotensin converting enzyme blockers (ARBs) may not be at risk for angioedema Gavras I Arch Int Med 2003; 163: 240-1
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  • 33. Vibratory angioedema Lawlor F et al Br J Dermatol 1989; 120: 93-99 Vortex to induce angioedema in a patient with swelling of hands while driving car
  • 34.
  • 35. B Cell Lymphoma Associated with Symptomatic Dermatographism Patient’s dermatographism resistant to fexofenadine and cetirizine sent a clue that something else may be causing her itching and hives.
  • 36.
  • 37. Antibodies associated with urticaria IgG auto ab to IgE receptor 35-40% Antithyroglobulin Ab 8% Antimicrosomal Ab 5%
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  • 39.