2. OUR IDEA:
• TO REPLACE EXISTING GOLD STANDARD METHOD OF SILICON
IMPLANTS IN FACIAL ESTETIC AND RECONSTRUCTION SURDGERY BY
INTRODUCING NOVEL MATERIAL AND NOVEL METHOD OF
IMPLENTATION VIA 3D BIOPRINTING
3. PROJECTIONS OF GLOBAL COSMETIC IMPLANTS
MARKET SIZE
• "Global Cosmetic Implants Market Size, Share And Trends Report Up
To 2020 : Radiant Insights To 2020“ made projection of 9,29 Billion by
2020.
• According to estimates published by the American Society of Plastic
Surgeons in 2013, residents of the U.S. spent nearly USD 7.0 billion in
cosmetic surgical procedures
• Facial Implants are expected grow at a lucrative rate during the
forecast period owing to increasing popularity of celebrities, who in
turn motivate younger generation to look aesthetically appealing.
4. “GOLD STANDARD” OF FACIAL SURDGERY
• SILICONE IMPLANTS MOST POPULAR IMPLEMENTATION IN ESTETIC
PLASTIC SURDGERY IS CHEEK, CHIN AND MANDIBULAR IMPLANTS:
9. Because of drawbacks of silicone material
properties and technique of implantation many
complications may occur
• Rate of rejection of silicone implants is estimated from 1:7 to 1:9 in
different works
• Problems can also occur after impact in region of implant
10. Silicone implants replacement with
hydroxyapatite based scaffold
• Aim of our project is to replace silicone implants in facial surgery with
hydroxyapatite (artificial bone) scaffold
• For that purpose we have tested novel material, ALBO-OS, that is proven
better than current gold standard artificial bone Bio-Oss®:
• Jokanović V., ČolovićB., Marković D., Petrović M., Jokanović M., Milosavljević P., Sopta
J.,In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA,
2016 (2016),Article ID 3948768, 10 pages, http://dx.doi.org/10.1155/2016/3948768.
• Jokanović V, Čolović B, Marković D, Petrović M, Soldatović I, Antonijević
Dj., Milosavljević P, Sjerobabin N, Sopta J., Extraordinary biological properties of a
new calcium hydroxyapatite/poly(lactide-co- glycolide)-based scaffold confirmed by
in vivo investigation, doi: 10.1515/bmt-2015- 0164.
• Sjerobabin N. , Čolović B. , Petrović M. , Marković D. , Živković S. , Jokanović V.,
Cytotoxicity investigation of a new hydroxyapatite scaffold with improved structural
design, 144, (2016), (5-6), 280-287.
11. Main advantages: our material / silicone
implants
• Practically no rejection / 1:8 or worse rejection rate
• Osteointegration and osteoinductivity / osteoresorption
• High stability and impact resistance / lower stability and low impact
resistance
• Vascularization and remodeling (complete integration of graft in to
organism) / can not integrate and have to be replaced in time
12. Our team:
• Prof. Marija Djuric and Anthropology Lab Belgrade
(http://www.anthropologylab-bg.com/research/index.html )
• Prof. Vukoman Jokanovic, Institute for Nuclear Sciences Vinca
(https://www.researchgate.net/publication/299483559_In_vivo_inve
stigations_of_ALBO-
OS_scaffold_based_on_hydroxyapatite_and_PLGA )
• Miroslav Gasic and Milutin Micic, Tesla Design
13. • As you can see in the links on the previous page our team has top
results on the SCI index list. Laboratory for anthropology is the best
ranking laboratory in our University and results of prof. Vukoman are
visible both in Laboratory for materials of Institute for Nuclear
Sciences Vinca and in private enterprise through cooperation with top
ranking companies.
• Equipment in our possession in worth around 400.000 E and includes
micro CT for estimating bone microstructure, CT, CBTC and so on.
