Details about 12 principle of green chemistry and its application in organic synthesis

1. 12 PRINCIPLES OF
GREEN CHEMISTRY
SHUCHETA . MISHRA
M.SC (CHEMISTRY)

2. (It’s Not Easy
Being Green)

3. HISTORY
• Bhopal disaster, India
1984, methyl isocyanate – Nearly 25,000 death

4. • Schweizerhalle (Switzerland)
12 tons - Mercury ethoxyethyl-hydroxyde- Fungicide
Several tones of fishes were dead in Rhine river
• Minamata, Japan
Methyl mercury,- Fish – People.
1000 people died

5. DEFINITION OF GREEN CHEMISTRY
1. The design of chemical products and processes that are more
environmentally benign and reduced negative impact to human health
and the environment .
2. Green Chemistry is the utilization of a set of principles that reduces or
eliminates the use of generation of hazardous substances in the
design, manufacture and application of chemical product.

6. PRINCIPLE
1) Prevent Waste
2) Atom Economy
3) Use and production of Less Hazardous Chemical
4) Designing safer chemicals
5) Minimize the use of solvents and auxiliaries
6) Design for Energy Efficiency
7) Use of renewable Feed stock
8) Reduce Derivatives
9) Catalytic reagents are superior to stoichiometric reagent
10) Design for Degradation
11) Real-time analysis for Pollution Prevention
12) Inherently Safer Chemistry for Accident Prevention

7. PREVENT WASTE
• It is better to prevent waste than to treat or clean up waste.
• After it has been created we should have to disposed it properly.
ATOM ECONOMY
• Synthetic methods should be designed to maximize the incorporation of
all materials used in the process into the final product

8. USE AND PRODUCTION OF LESS HAZARDOUS CHEMICAL
• Polycarbonate Synthesis : Phosgene Process

9. • Phosgene -toxic corrosive , large CH2Cl2 required, contaminated
with Cl impurities.

10. MINIMIZE THE USE OF SOLVENTS AND AUXILIARIES

11. DESIGN FOR ENERGY EFFICIENCY
• Microwave technique
• Ultrasonic technique
• Solar energy
(Use of renewable Energy Sources)

12. DESIGN FOR DEGRADATION
• Can we recycle everything.
• Design it so that it breaks down at the end of its useful lifetime.
INHERENTLY SAFER CHEMISTRY FOR ACCIDENT PREVENTION
• Substances and the form of a substance used in a chemical process should
be chosen so as to minimize the potential for chemical accidents, including
releases, explosions, and fires.

13. Chemists Must Place a Major Focus on the Environmental
WE MUST CONSIDER OUR CHEMICAL ECOLOGICAL FOOTPRINT

14. THANK YOU