Thyroid cancer for undergraduate level

1. Thyroid Cancer
Mohammed Fathy Bayomy, MSc, MD
Lecturer of Clinical Oncology
Clinical Oncology & Nuclear Medicine Department
Faculty of Medicine
Zagazig University

2. The most common cancer
of endocrine system
Papillary, follicular
and medullary
Young
Female
4X
Male

3. Nuclear fallout
Neck irradiation
MEN2
syndrome
Medullary Thyroid
Carcinoma
RET gene
Chr.10
Endemic goitre
Hereditary

4. Differentiated Thyroid
Carcinoma (DTC) (90%)
Papillary Thyroid
Carcinoma (PTC)
(80%)
Follicular Thyroid
Carcinoma (FTC)
Poorly differentiated
Thyroid Carcinoma
(PDTC)
Hürthle cell Thyroid
Carcinoma (HTC)
Anaplastic Thyroid
Carcinoma (ATC)
Medullary thyroid
cancer (MTC)
(3%)(5%)
Other tumors
Lymphoma
Sarcoma

5. Asymptomatic
Enlarging
mass in neck
Cervical or SC
lymphadenopathy
Stridor
Hoarseness
Neck pain
Dysphagia
Secretory
diarrhea
Distant
metastases

6. Radionuclide
thyroid scan
Thyroid
ultrasonography
CT &/or MRI of Head & Neck Pathological
confirmation
Thyroid Biopsy
Laboratory
RET
mutation
Chest Imaging

7. T stage
M stageN stage
T1 T2 T3 T4
N1a N1b M1

8. Differentiated Thyroid
Cancer
Surgery
Lobectomy
Neck lymph node
dissection
Total or near-total
Thyroidectomy
Medullary Thyroid
Cancer
Anaplastic Thyroid
cancer
Radioactive iodine
(RAI)
Hormonal Therapy
I-131
Thyroxine
Surgery Surgery
Total
Thyroidectomy
Neck lymph node
dissection
Adjuvant
Radiotherapy
Palliative Radiotherapy
Chemotherapy
dacarbazine-based regimens
Targeted Therapy (TKI)
Vandetanib Cabozantinib
Radiotherapy
Hyperfractionated
Concurrent
Chemotherapy
Doxorubicin
+
Chemotherapy
Doxorubicin
Doxorubicin
+Cisplatin