Call Girls Rishikesh Just Call 9667172968 Top Class Call Girl Service Available
Is It Diabetic Nephropathy? (When to Biopsy?) - Dr. Gawad
1. Is It Diabetic Nephropathy?
(When to Biopsy?)
Mohammed Abdel Gawad
Nephrologist – Alexandria – Egypt
Founder & Chairman of NephroTube
drgawad@gmail.com
2. IMPORTANT MESSAGE
• Renal diseases in diabetic patients are NOT
ALWAYS due to diabetic nephropathy and
even it may not be due to DM.
Hematuria Proteinuria Rising creatinine Others
3. IMPORTANT MESSAGE
• Renal diseases in diabetic patients are NOT
ALWAYS due to diabetic nephropathy and
even it may not be due to DM.
Hematuria Proteinuria Rising creatinine Others
4. Renal & Urological Problems that may
be presented in Diabetics
Papillary necrosis
- Ischemic nephropathy due to
microvascular disease
- Renal artery stenosis
Diabetic glomerulopathy
(diabetic nephropathy)
Autonomic neuropathy of the
bladder
UTI
Any other glomerular disease
not related to DM
- Drug induced
- Other ppt factors for AKI
5. Renal & Urological Problems that may
be presented in Diabetics
Papillary necrosis
- Ischemic nephropathy due to
microvascular disease
- Renal artery stenosis
Diabetic glomerulopathy
(diabetic nephropathy)
Autonomic neuropathy of the
bladder
UTI
Any other glomerular disease
not related to DM
- Drug induced
- Other ppt factors for AKI
6. Renal & Urological Problems that may
be presented in Diabetics
Papillary necrosis
- Ischemic nephropathy due to
microvascular disease
- Renal artery stenosis
Diabetic glomerulopathy
(diabetic nephropathy)
Autonomic neuropathy of the
bladder
UTI
Any other glomerular disease
not related to DM
- Drug induced
- Other ppt factors for AKI
When to suspect other cause rather than DN?
Is it DN?
When to biopsy?
7. Is it Diabetic Nephropathy?
You have to answer the following
1. What is the type of DM?
2. Is there an evidence of Diabetic retinopathy?
3. Proteinuria:
a. Is the evolution of proteinuria is typical (micro then macro)?
b. Is the range of proteinuria coincides with DN stage?
c. What is the rate of proteinuria progression?
4. Hematuria: Is it microscopic or macroscopic?
5. Rising Cr and decreasing GFR:
a. Is it related to proteinuria?
b. What is the rate of renal impairment progression?
6. Hypertension: refractory or not?
7. What is the drug history?
8. Is there any ppt factor for AKI?
8. Is it Diabetic Nephropathy?
You have to answer the following
1. What is the type of DM?
2. Is there an evidence of Diabetic retinopathy?
3. Proteinuria:
a. Is the evolution of proteinuria is typical (micro then macro)?
b. Is the range of proteinuria coincides with DN stage?
c. What is the rate of proteinuria progression?
4. Hematuria: Is it microscopic or macroscopic?
5. Rising Cr and decreasing GFR:
a. Is it related to proteinuria?
b. What is the rate of renal impairment progression?
6. Hypertension: refractory or not?
7. What is the drug history?
8. Is there any ppt factor for AKI?
10. Diabetic Nephropathy & Diabetic Retinopathy
Type 1 DM
Pre
(1 &2)
Incipient (3)
(microalbuminuria
& HTN)
Overt (4)
(proteinuria,
nephrotic syndrome
and decreasing GFR)
ESRD (5)
At 5 years from onset of DM type 1,
nephropathy coincides with
retinopathy
So if nephropathy is evident in absence
of retinopathy in Type 1 DM
Search for other cause of
nephropathy rather that DM ±
Renal Biopsy
(especially if there is S&S of
other systemic disease)
Diabetic retinopathy is present in virtually
all patients with type 1 diabetes and
nephropathy *
* Girach A, Vignati L. Diabetic microvascular complications. J Diabetes Complications. 2006;20:228-237.
5y 15y 25y
11. Diabetic Nephropathy & Diabetic Retinopathy
Type 1 DM
Pre
(1 &2)
Incipient (3)
(microalbuminuria
& HTN)
Overt (4)
(proteinuria,
nephrotic syndrome
and decreasing GFR)
ESRD (5)
At 5 years from onset of DM type 1,
nephropathy coincides with
retinopathy
So if nephropathy is evident in absence
of retinopathy in Type 1 DM
Search for other cause of
nephropathy rather that DM ±
Renal Biopsy
(especially if there is S&S of
other systemic disease)
Diabetic retinopathy is present in virtually
all patients with type 1 diabetes and
nephropathy *
* Girach A, Vignati L. Diabetic microvascular complications. J Diabetes Complications. 2006;20:228-237.
5y 15y 25y
12. Diabetic Nephropathy & Diabetic Retinopathy
Type 2 DM
± Renal
Biopsy
Only 50% to 60% of proteinuric
patients with type 2 diabetes
suffer from retinopathy. **
Consequently, the absence of
retinopathy does not exclude
the diagnosis of DN in patients
with type 2 diabetes.
*
In type 2 DM the prevalence of
nondiabetic renal disease could
vary from 12 to 38% ***
When to suspect other
cause****?
1- Younger patients with DM
2- Short duration of DM
3- Atypical presentation (atypical
proteinuria or hematuria, rapid rising
Cr ….. etc) or other ppt factors
(discussed later)
When to
suspect other
cause?
* GIUSEPPE REMUZZI et al. N Engl J Med, Vol. 346, No. 15· April 11, 2002
*** Huang F et al. Clin ephrol 2007, 67: 293-297.
**** Pham TT et al. Am J Nephrol. 2007;27:322-328.
** Wolf G, Müller N, Mandecka A, Müller UA. Clin Nephrol. 2007;68:81-86.
13. Is Fluorescein Angiography Safe in
Diabetics with Renal Impairment?
DIABETES CARE, VOLUME 32, NUMBER 3, MARCH 2009
14. Is Fluorescein Angiography Safe in
Diabetics with Renal Impairment?
M.J. ALEMZADEH-ANSARI ET AL. Nefrologia 2011;31(5):612-3
15. Is it Diabetic Nephropathy?
You have to answer the following
1. What is the type of DM?
2. Is there an evidence of Diabetic retinopathy?
3. Proteinuria:
a. Is the evolution of proteinuria is typical (micro then macro)?
b. Is the range of proteinuria coincides with DN stage?
c. What is the rate of proteinuria progression?
4. Hematuria: Is it microscopic or macroscopic?
5. Rising Cr and decreasing GFR:
a. Is it related to proteinuria?
b. What is the rate of renal impairment progression?
6. Hypertension: refractory or not?
7. What is the drug history?
8. Is there any ppt factor for AKI?
16. Diabetic Nephropathy & Proteinuria
Pre
(1 &2)
Incipient (3)
(microalbuminuria
& HTN)
Overt (4)
(proteinuria,
nephrotic syndrome
and decreasing GFR)
ESRD (5)
If evolution of
proteinuria is atypical:
development of overt
proteinuria without
previous
microalbuminuria.
Search for other cause of nephropathy
rather that DM ± Renal Biopsy
(especially if there is S&S of other
systemic disease)
If the onset of
proteinuria has
been sudden and
rapid
10-15 years
Overt proteinuria
in diabetes type 1
for <10 years
Rate of proteinuria
progression is slow
5y 15y 25y
17. DN without Albuminuria
Ischemic Nephropathy – Type 2 DM
• Renal ultrasound reveals small kidneys.
• Raised Serum Cr after administration of ACE-i
• Without albuminuria
Jamine P. Dwyer et al. DEMAND study. Cardiorenal Med, 2012;2:1-10
20. Jamine P. Dwyer et al. DEMAND study. Cardiorenal Med, 2012;2:1-10
21. • MARK E. MOLITCH. Diabetes Care 33:1536–1543, 2010
•Also same results are reported in:
•Caramori ML et al. Diabetes 52:1036-1040, 2003.
•Lane PH et al. Diabetes 41:581-586, 1992
•MacIsaac RJ et al. Diabetes Care 27:195-200,2004
DN without Albuminuria - Type 1 DM
22. Is it Diabetic Nephropathy?
You have to answer the following
1. What is the type of DM?
2. Is there an evidence of Diabetic retinopathy?
3. Proteinuria:
a. Is the evolution of proteinuria is typical (micro then macro)?
b. Is the range of proteinuria coincides with DN stage?
c. What is the rate of proteinuria progression?
4. Hematuria: Is it microscopic or macroscopic?
5. Rising Cr and decreasing GFR:
a. Is it related to proteinuria?
b. What is the rate of renal impairment progression?
6. Hypertension: refractory or not?
7. What is the drug history?
8. Is there any ppt factor for AKI?
23. Diabetic Nephropathy & Hematuria
Is it Micro or Macroscopic?
Hematuira in diabetic patient
Microscopic
hematuria is seen in
66% of patients with
DN *
Macroscopic hematuria
±
active nephritic urinary sediment
(acanthocytes and red cell casts)
Search for other cause of nephropathy
rather that DM ± Renal Biopsy
(especially if there is S&S of other systemic
disease)
* Akimoto T, Ito C, Saito O, et al. Nephron Clin Pract. 2008; 109:c119-c126.
** Lopes de Faria et al. Clin Nephrol. 1988;30(3):117
Red blood cell casts have
also been described in
patients with diabetic
nephropathy **
24. Is it Diabetic Nephropathy?
You have to answer the following
1. What is the type of DM?
2. Is there an evidence of Diabetic retinopathy?
3. Proteinuria:
a. Is the evolution of proteinuria is typical (micro then macro)?
b. Is the range of proteinuria coincides with DN stage?
c. What is the rate of proteinuria progression?
4. Hematuria: Is it microscopic or macroscopic?
5. Rising Cr and decreasing GFR:
a. Is it related to proteinuria?
b. What is the rate of renal impairment progression?
6. Hypertension: refractory or not?
7. What is the drug history?
8. Is there any ppt factor for AKI?
25. Diabetic Nephropathy & Renal Impairment
Pre
(1 &2)
Incipient (3)
(microalbuminuria
& HTN)
Overt (4)
(proteinuria,
nephrotic syndrome
and decreasing GFR)
ESRD (5)
Search for other cause
If renal impairment is rapid
Significant proteinuria without/with
non coinciding renal impairment
first, of course, renovascular
disease must be excluded
other cause of nephropathy
rather that DM ± Renal Biopsy
(especially if there is S&S of
other systemic disease)
Rate of renal
impairment
progression is slow
5y 15y 25y
26. Is it Diabetic Nephropathy?
You have to answer the following
1. What is the type of DM?
2. Is there an evidence of Diabetic retinopathy?
3. Proteinuria:
a. Is the evolution of proteinuria is typical (micro then macro)?
b. Is the range of proteinuria coincides with DN stage?
c. What is the rate of proteinuria progression?
4. Hematuria: Is it microscopic or macroscopic?
5. Rising Cr and decreasing GFR:
a. Is it related to proteinuria?
b. What is the rate of renal impairment progression?
6. Hypertension: refractory or not?
7. What is the drug history?
8. Is there any ppt factor for AKI?
27. Diabetic Nephropathy & Refractory HTN
Refractory hypertension (and fluid
retention) in diabetic patients is highly
suggestive for renovascular disease
28. Is it Diabetic Nephropathy?
You have to answer the following
1. What is the type of DM?
2. Is there an evidence of Diabetic retinopathy?
3. Proteinuria:
a. Is the evolution of proteinuria is typical (micro then macro)?
b. Is the range of proteinuria coincides with DN stage?
c. What is the rate of proteinuria progression?
4. Hematuria: Is it microscopic or macroscopic?
5. Rising Cr and decreasing GFR:
a. Is it related to proteinuria?
b. What is the rate of renal impairment progression?
6. Hypertension: refractory or not?
7. What is the drug history?
8. Is there any ppt factor for AKI?
29. Diabetic Nephropathy & Drugs
ACEi & ARBs
> 30% reduction in GFR
within 2-3 months after
initiation
Suspect renovascular
disease
30. Diabetic Nephropathy & Drugs
ContrastNSAIDs
Diabetics kidneys are at
high risk to be affected
by nephrotoxic drugs
Any other nephrotoxic
drug
31. Is it Diabetic Nephropathy?
You have to answer the following
1. What is the type of DM?
2. Is there an evidence of Diabetic retinopathy?
3. Proteinuria:
a. Is the evolution of proteinuria is typical (micro then macro)?
b. Is the range of proteinuria coincides with DN stage?
c. What is the rate of proteinuria progression?
4. Hematuria: Is it microscopic or macroscopic?
5. Rising Cr and decreasing GFR:
a. Is it related to proteinuria?
b. What is the rate of renal impairment progression?
6. Hypertension: refractory or not?
7. What is the drug history?
8. Is there any ppt factor for AKI?
32. ppt factors for AKI in Diabetics
They are the same as any high risk population
1. Dehydration (fluid loss, hyperglycemia, decrease fluid
intake).
2. UTI.
3. Drugs.
4. Cardiac problem.
5. Septicemia.
6. Surgery.
33. USS & Renal Biopsy
• If renal ultrasound reveals small kidneys it is
prudent not to perform biopsy.
• Overall, renal biopsy is indicated only in a
small minority of diabetic patients.
37. Pathology
Pathology - DiffusePathology - Nodular
Kimmelstiel Wilson nodules
Pathognomonic for diabetes
But reported in only 10% to 50% of
biopsy specimens in both type 1
and type 2 diabetes.
38. Pathology
Pathology - DiffusePathology - Nodular
Kimmelstiel Wilson nodules - MORE FREQUENT than the nodular lesion
- Correlates with the clinical manifestations
of worsening renal function
42. Diabetes & Kidney Scenarios
Diabetic with
recent discovered
renal problem
Due to DN Not due to DN
Diabetic with
known old DN &
recent renal
problem
Due to DN Not due to DN
To Conclude
43. To Conclude
When to suspect other Cause(s) of Renal
Disease rather than DN? (Is it DN?)
!!!!!!!
44. To Conclude
When to suspect other Cause(s) of Renal
Disease rather than DN? (Is it DN?) – Step 1
Step 1:
Renal US
Evidence of
chronic
changes
No need for
biopsy
No evidence
of chronic
changes
Go to Step 2
45. To Conclude
When to suspect other Cause(s) of Renal Disease
rather than DN? (Is it DN?) – Step 2
Suspect other cause rather that DN if:
Diabetic retinopathy - Absent in Type 1
- Absent in type 2 +
1- Short duration of DM
2- Atypical presentation or other ppt factors
Proteinuria & Nephrotic syndrome
(Don’t forget DN without
albuminuria)
- Development of overt proteinuria without previous microalbuminuria
- Overt proteinuria in diabetes type 1 for <10 years
- If the onset of proteinuria has been sudden and rapid
- Resistant Nephrotic Syndrome
Hematuria Macroscopic hematuria & active urinary sediment
(Don’t forget casts are described in DN also)
Rising Cr and decreasing GFR - If renal impairment is rapid
- If significant proteinuria without renal impairment
Hypertension Refractory HTN
Drug history - ACEi & ARBs: > 30% reduction in GFR within 2-3 months after initiation
- NSAIDs & Contrast
- Others
ppt factor for AKI Dehydration, UTI, Drugs, Cardiac problem, Septicemia, Surgery.
Systemic disease S&S of other systemic disease
Red and green colored indications are not listed in KDOQI Guidelines for Diabetes & CKD
53. Take Home Message
• Renal diseases in diabetic patients are NOT
ALWAYS due to diabetic nephropathy and
even it may not be due to DM.
Hematuria Proteinuria Rising creatinine Others