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signs & symptoms clinical pathway tract disorders causes drugs risk factors body thermal regultion temperature thermoregulation anterolateral system spinothalamic anterior lateral sensory ascending septic shock factors stages pyramidal descending motor complications cns git manifistation hiv respiratory system central nervous system gastrointestinal tract mydriatics dorzolamide treatment glaucoma timolol anti-glaucoma inherited disease bleeding hemophilia von willebrand acquired genetics vwd deficiency glucose-6-phosphate dehydrogenase deficiency glucose-6-phosphate dehydrogenase classification pathology epilepsy mechanisms management diagnosis color discharge types otorrhea ear manifestation b cells t-cells development t cells b-cells immunology rating scales assessment differential dignosis depression type cranial hematoma injury fluid cerebrospinal neurological tremor conditions cerebral basilar supply blood circle of willis arteries brain vertebral hashimoto's thyroiditis hypothyroidism autoimmune arches ligaments foot fractures ankle anatomy movement joint bone morphology leukemia who classification immunophenotype laboratory findings french-american-british classification myelogenous acute