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By
Hidayatullah khan
KMU
Fluids & Electrolytes
imbalance
Composition of Body Compartments
 Total Body Water (TBW)= 50-75% of Total Body Mass
 TBW = Intracellular Fluid (ICF) + Extracellular Fluid (ECF)
 ICF = 2/3 of TBW
 ECF = 1/3 of TBW -- 25% of body weight
 ECF = Plasma (intravascular) + Interstitial fluid
Fluid % in child body ( 75%-80%)
Regulation of Body Fluids and Electr
olytes
 Anti-Diuretic Hormone (ADH)
 Thirst
 Aldosterone
 Atrial Natriuretic Factor
Daily Maintenance Requirements
Add 12 % for every
0
C
4cc, 2cc, 1cc rule
 4 cc for the first 10 kg
 2 cc for the next 10 kg
 1 cc for each kg after
 Example:
 27 kg child
 4 cc for the first 10 kg = 40cc
 2 cc for the next 10 kg = 20cc
 1 cc for each kg after = 7 cc
67 cc/hr
Estimation of Dehydration
Nursing requirements of FLUID
Increased requirement :
 Fever
 Vomiting
 Renal failure
 Burn
 Shock
 Tachypnea
 Gastroenteritis
 Diabetes (Insipidus, mellitus - DKA)
 Cystic fibrosis
Decreased requirement
 CHF
 Postoperatively
 oliguric ( RF )
 Increase ICP
Dehydration
 Classification
 Isotonic
 Serum Sodium 130-150 mEq
 Hypotonic
 Serum Sodium < 130 mEq
 Hypertonic
 Serum Sodium >150 mEq
Diagnostic Evaluation
1. Physical assessment (V/S)
2. Type of dehydration
Nursing Therapeutic management of fluid loss
 Oral rehydration therapy
 Parenteral fluid therapy
 Meet ongoing daily loss
 Replace previous deficit
Replace ongoing abnormal losses
Management of Dehydration
 General Principles:
 Supply Maintenance Requirements
 Correct volume and electrolyte deficit
 Replace ongoing abnormal losses
Management of Dehydration
 Oral Rehydration:
 Effective for mild and some moderate dehydrations
 Child may be able to tolerate PO intake
 Small aliquots as tolerated
 Mild: 50 cc/kg over 4 hours
 Moderate: 100 cc/kg over 4 hours
 2 types of oral solution
 Maintenance
 Rehydration
Composition of Body fluids
1. D5W (5 g sugar/100 ml)
2. D10W (10 g sugar/100 ml)
3. NS (0.9% NaCl) 9 gm NaCl/L
4. 1/2 NS (0.45% NaCl) 4.5gm/L
5. D5 .18 NS 1.80gm/L
6. 3% NaCl 30gm/L
IV fluids
Lactated Ringer’s
0-10 gram glucose/100cc
Na 130 meq/L
NaHCO3 28 meq/L as lactate
K 4 meq/L
Pediatric Fluid Therapy Principles
Assess water deficit by:
1. weight:
weight loss (Kg) = water loss (L)
OR
2. Estimation of water deficit by physical exam:
Mild moderate severe
Infants < 5 % 5 - 10 % >10
%
Older children < 3 % 3 - 6 % > 6 %
Physical Signs of Dehydration
Signs&sym
pt. M
IL
D M
oderate Severe
G
eneral T
hirsty, allert,
restless
T
hirsty, irritable,
ordrow
sy
D
row
sy–lim
p,
skincold/ sw
eaty
R
adial pulse N
orm
al rate R
apid, w
eak R
apid, feeble
R
espiration N
orm
al D
eep D
eep&rapid
A
nteriorfont. N
orm
al Sunken V
erysunken
Skinturgor P
inchretracts
im
m
ediately
R
etractsslow
ly P
oor
E
yes N
orm
al Sunken G
rosslysunken
T
ears P
resent A
bsent A
bsent
M
ucousm
em
b. M
oist D
ry V
erydry
U
rineflow N
orm
al D
ark&
decreased
O
liguria/ anuria
Correction of Dehydration
 Mild dehydration: increase oral intake
 Moderate to severe dehydration:
IV push
10-20 cc / Kg Normal saline
May repeat.
 Half deficit over 8 hours, and half over 16 hours.
 If hypernatremic dehydration, replace deficit over 48
hours .
Disturbance of acid based balance
Disturbance Plasma PH Plasma PCO2 Plasma HCO3
Respiratory
Acidosis
Respiratory
Alkalosis
Metabolic A
cidosis
Metabolic Al
kalosis
Nursing Intervention
1. Assessment
2. History
3. Clinical observation
4. Intake & output measurement
5. Replace orally or IVF
( 1g wet diaper wt =1 ml urine )
When administrating I.V fluid nurse
should
 Monitors the response of the
fluids.
 Considering the fluid volume.
 Content of fluid.
 Patient clinical status.
Hyponatremia
 Predisposing Factors
 Diabetes mellitus (hyperglycemia)
 Cystic fibrosis
 Gastroenteritis
 Excessive water intake (formula dilution)
 Diuretics (thiazides and furosemide)
 Renal disease
 Vomiting, diarrhea, sweating, and burns cause Na+
loss. Dehydration, tachycardia
and shock (see above) can result. Intake of plain water
worsens the condition.
Pedialyte is a better fluid to drink.
Hyponatremia
 Hyponatremic Dehydration
 Hypovolemic Hyponatremic Dehydration
 High urine output and Na excretion
 Increase in atrial natriuretic factor
 Hypervolemic Hyponatremic Dehydration
 Edematous disorder (nephrotic syndrome, CHF, cirrhosis)
Hyponatremia
 Acute Hyponatremia (<24 hours)
 Early Onset (Serum Sodium <125 meq/L)
 Nausea
 Vomiting
 Headache
 Later or Severe (Serum Sodium <120 meq/L)
 Seizure
 Coma
 Respiratory arrest
Hyponatremia
 Chronic Hyponatremia (>48 hours)
 Lethargy
 Confusion
 Muscle cramps
 Neurologic Impairment
Hyponatremia
 Management
 Na Deficit:
 Na Deficit = (Na Desired - Na observed) x 0.6 x body weight(kg)
 Replace half in first 8 hours and the rest in the following
16 hours
 Rise in serum Na should not exceed 2 mEq/L/h to
prevent Central Pontine Myelinolysis
 In cases of severe hyponatremia (<120 mEq) with CNS
symptoms:
 3% NaCl 3-5 ml/kg IV push for hyponatremia induced seizures
 6 ml/kg of NaCl will raise serum Na by 5 mEq/L
Hypernatremia
 Hypernatremia leads to hypertonicity
 Increase secretion of ADH
 Increase thirst
 Patients at risk
 Inability to secrete or respond to ADH
 No access to water
Hypernatremia
 Etiology
 Pure water depletion
 Diabetes insipidus (Central or Nephrogenic)
 Sodium excess
 Salt poisoning (PO or IV)
 Water depletion exceeding Na depletion
 Diarrhea, vomiting, decrease fluid intake
 Pharmacologic agents
 Lithium, Cyclophosphamide, Cisplatin
Hypernatremia
 Signs and symptoms
 Disturbances of consciousness
 Lethargy or Confusion
 Neuromuscular Irritability
 Muscle twitching, hyperreflexia
 Convulsions
 Hyperthermia
 Skin may feel thick
Hypernatremia
 Management
 Normal Saline or Ringer lactate to restore volume
 Hypotonic solution (D5 1/5 NS) to correct calculated
deficit over 48 hours
 Water Deficit
 Normal body H20 - Current body H20
 Current body water
 0.6 x body weight (kg) x Normal Na/Observed Na
 Normal Body water
 0.6 x body weight (kg)
 Decrease Na concentration at a rate of 0.5 mEq/hr or
~ 10 mEq/day: Faster correction can result in
Cerebral Edema
Potassium
 Most abundant intracellular cation
 Normal serum values 3.5-5.5 mEq
 Abnormalities of serum K are potentially life-
threatening due to effect in cardiac function
Hypokalemia
 Diagnosis
 Symptoms
 Arrhythmias
 Neuromuscular excitability (hyporreflexia, paralysis)
 Gastrointestinal (decreased peristalsis or ileus)
 Serum K < 3mEq/L
 ECG:
 Flat T waves
 Short P-R interval and QRS
 U waves
Hypokalemia
Nutritional GI Loss Renal Loss Endocrine
Poor intake Diarrhea Renal tubular acidosis Insulin therapy
IVF low in K Vomiting Chronic renal disease Glucose therapy
Anorexia Malabsorbtion Fanconi's syndrome DKA
Intestinal fistula Gentamicin, Hyperaldosteronism
Laxatives Amphotericin Adrenal adenomas
Enemas Diuretics Mineralocorticoids
Bartter's syndrome
Bartter’s syndrome: Hypereninemia and hyperaldosteronism
Hypokalemia
 Management:
 Cardiac Arrhythmias or Muscle Weakness
 KCl IV (cardiac monitor)
 PO K - Depend of etiology
 Hypophoshatemia = KPO4
 Metabolic acidosis = KCl
 Renal tubular acidosis = K citrate
Hyperkalemia
 Differential Diagnosis
 Pseudohyperkalemia - from blood hemolysis
 Metabolic Acidosis
 Chronic Renal Failure
 Congenital Adrenal Hyperplasia
 Females = Usually Dx at birth - Ambiguous Genitalia
 Males = Dehydration, hyponatremia, hyperkalemia
 Medications
 ACE inhibitors and NSAID’s
Hyperkalemia
 Diagnosis:
 Symptoms
 Cardiac Arrhythmias
 Paresthesias
 Muscle weakness or paralysis
 ECG
 Peaked T waves
 Short QT interval (K>6 mEq)
 Depressed ST segment
 Wide QRS (K>8 mEq)
Hyperkalemia
 Management
 Close cardiac monitoring
 Life -threatening hyperkalmia
 Intravenous Calcium - rapid onset, duration< 30 min
 NaHCO3 or glucose and insulin
 Ion exchange resins
 Sodium polystyrene sulfonate (Kayexelate)
 PO or Enema
 Hemodyalisis

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Fluids and Electrolytes Imbalance: Causes, Signs, Nursing Care

  • 1. By Hidayatullah khan KMU Fluids & Electrolytes imbalance
  • 2. Composition of Body Compartments  Total Body Water (TBW)= 50-75% of Total Body Mass  TBW = Intracellular Fluid (ICF) + Extracellular Fluid (ECF)  ICF = 2/3 of TBW  ECF = 1/3 of TBW -- 25% of body weight  ECF = Plasma (intravascular) + Interstitial fluid Fluid % in child body ( 75%-80%)
  • 3. Regulation of Body Fluids and Electr olytes  Anti-Diuretic Hormone (ADH)  Thirst  Aldosterone  Atrial Natriuretic Factor
  • 5. 4cc, 2cc, 1cc rule  4 cc for the first 10 kg  2 cc for the next 10 kg  1 cc for each kg after  Example:  27 kg child  4 cc for the first 10 kg = 40cc  2 cc for the next 10 kg = 20cc  1 cc for each kg after = 7 cc 67 cc/hr
  • 7. Nursing requirements of FLUID Increased requirement :  Fever  Vomiting  Renal failure  Burn  Shock  Tachypnea  Gastroenteritis  Diabetes (Insipidus, mellitus - DKA)  Cystic fibrosis
  • 8. Decreased requirement  CHF  Postoperatively  oliguric ( RF )  Increase ICP
  • 9. Dehydration  Classification  Isotonic  Serum Sodium 130-150 mEq  Hypotonic  Serum Sodium < 130 mEq  Hypertonic  Serum Sodium >150 mEq
  • 10. Diagnostic Evaluation 1. Physical assessment (V/S) 2. Type of dehydration Nursing Therapeutic management of fluid loss  Oral rehydration therapy  Parenteral fluid therapy  Meet ongoing daily loss  Replace previous deficit Replace ongoing abnormal losses
  • 11. Management of Dehydration  General Principles:  Supply Maintenance Requirements  Correct volume and electrolyte deficit  Replace ongoing abnormal losses
  • 12. Management of Dehydration  Oral Rehydration:  Effective for mild and some moderate dehydrations  Child may be able to tolerate PO intake  Small aliquots as tolerated  Mild: 50 cc/kg over 4 hours  Moderate: 100 cc/kg over 4 hours  2 types of oral solution  Maintenance  Rehydration
  • 13. Composition of Body fluids 1. D5W (5 g sugar/100 ml) 2. D10W (10 g sugar/100 ml) 3. NS (0.9% NaCl) 9 gm NaCl/L 4. 1/2 NS (0.45% NaCl) 4.5gm/L 5. D5 .18 NS 1.80gm/L 6. 3% NaCl 30gm/L
  • 14. IV fluids Lactated Ringer’s 0-10 gram glucose/100cc Na 130 meq/L NaHCO3 28 meq/L as lactate K 4 meq/L
  • 15. Pediatric Fluid Therapy Principles Assess water deficit by: 1. weight: weight loss (Kg) = water loss (L) OR 2. Estimation of water deficit by physical exam: Mild moderate severe Infants < 5 % 5 - 10 % >10 % Older children < 3 % 3 - 6 % > 6 %
  • 16. Physical Signs of Dehydration Signs&sym pt. M IL D M oderate Severe G eneral T hirsty, allert, restless T hirsty, irritable, ordrow sy D row sy–lim p, skincold/ sw eaty R adial pulse N orm al rate R apid, w eak R apid, feeble R espiration N orm al D eep D eep&rapid A nteriorfont. N orm al Sunken V erysunken Skinturgor P inchretracts im m ediately R etractsslow ly P oor E yes N orm al Sunken G rosslysunken T ears P resent A bsent A bsent M ucousm em b. M oist D ry V erydry U rineflow N orm al D ark& decreased O liguria/ anuria
  • 17. Correction of Dehydration  Mild dehydration: increase oral intake  Moderate to severe dehydration: IV push 10-20 cc / Kg Normal saline May repeat.  Half deficit over 8 hours, and half over 16 hours.  If hypernatremic dehydration, replace deficit over 48 hours .
  • 18. Disturbance of acid based balance Disturbance Plasma PH Plasma PCO2 Plasma HCO3 Respiratory Acidosis Respiratory Alkalosis Metabolic A cidosis Metabolic Al kalosis
  • 19. Nursing Intervention 1. Assessment 2. History 3. Clinical observation 4. Intake & output measurement 5. Replace orally or IVF ( 1g wet diaper wt =1 ml urine )
  • 20. When administrating I.V fluid nurse should  Monitors the response of the fluids.  Considering the fluid volume.  Content of fluid.  Patient clinical status.
  • 21. Hyponatremia  Predisposing Factors  Diabetes mellitus (hyperglycemia)  Cystic fibrosis  Gastroenteritis  Excessive water intake (formula dilution)  Diuretics (thiazides and furosemide)  Renal disease
  • 22.  Vomiting, diarrhea, sweating, and burns cause Na+ loss. Dehydration, tachycardia and shock (see above) can result. Intake of plain water worsens the condition. Pedialyte is a better fluid to drink.
  • 23. Hyponatremia  Hyponatremic Dehydration  Hypovolemic Hyponatremic Dehydration  High urine output and Na excretion  Increase in atrial natriuretic factor  Hypervolemic Hyponatremic Dehydration  Edematous disorder (nephrotic syndrome, CHF, cirrhosis)
  • 24. Hyponatremia  Acute Hyponatremia (<24 hours)  Early Onset (Serum Sodium <125 meq/L)  Nausea  Vomiting  Headache  Later or Severe (Serum Sodium <120 meq/L)  Seizure  Coma  Respiratory arrest
  • 25. Hyponatremia  Chronic Hyponatremia (>48 hours)  Lethargy  Confusion  Muscle cramps  Neurologic Impairment
  • 26. Hyponatremia  Management  Na Deficit:  Na Deficit = (Na Desired - Na observed) x 0.6 x body weight(kg)  Replace half in first 8 hours and the rest in the following 16 hours  Rise in serum Na should not exceed 2 mEq/L/h to prevent Central Pontine Myelinolysis  In cases of severe hyponatremia (<120 mEq) with CNS symptoms:  3% NaCl 3-5 ml/kg IV push for hyponatremia induced seizures  6 ml/kg of NaCl will raise serum Na by 5 mEq/L
  • 27. Hypernatremia  Hypernatremia leads to hypertonicity  Increase secretion of ADH  Increase thirst  Patients at risk  Inability to secrete or respond to ADH  No access to water
  • 28. Hypernatremia  Etiology  Pure water depletion  Diabetes insipidus (Central or Nephrogenic)  Sodium excess  Salt poisoning (PO or IV)  Water depletion exceeding Na depletion  Diarrhea, vomiting, decrease fluid intake  Pharmacologic agents  Lithium, Cyclophosphamide, Cisplatin
  • 29. Hypernatremia  Signs and symptoms  Disturbances of consciousness  Lethargy or Confusion  Neuromuscular Irritability  Muscle twitching, hyperreflexia  Convulsions  Hyperthermia  Skin may feel thick
  • 30. Hypernatremia  Management  Normal Saline or Ringer lactate to restore volume  Hypotonic solution (D5 1/5 NS) to correct calculated deficit over 48 hours  Water Deficit  Normal body H20 - Current body H20  Current body water  0.6 x body weight (kg) x Normal Na/Observed Na  Normal Body water  0.6 x body weight (kg)  Decrease Na concentration at a rate of 0.5 mEq/hr or ~ 10 mEq/day: Faster correction can result in Cerebral Edema
  • 31. Potassium  Most abundant intracellular cation  Normal serum values 3.5-5.5 mEq  Abnormalities of serum K are potentially life- threatening due to effect in cardiac function
  • 32. Hypokalemia  Diagnosis  Symptoms  Arrhythmias  Neuromuscular excitability (hyporreflexia, paralysis)  Gastrointestinal (decreased peristalsis or ileus)  Serum K < 3mEq/L  ECG:  Flat T waves  Short P-R interval and QRS  U waves
  • 33. Hypokalemia Nutritional GI Loss Renal Loss Endocrine Poor intake Diarrhea Renal tubular acidosis Insulin therapy IVF low in K Vomiting Chronic renal disease Glucose therapy Anorexia Malabsorbtion Fanconi's syndrome DKA Intestinal fistula Gentamicin, Hyperaldosteronism Laxatives Amphotericin Adrenal adenomas Enemas Diuretics Mineralocorticoids Bartter's syndrome Bartter’s syndrome: Hypereninemia and hyperaldosteronism
  • 34. Hypokalemia  Management:  Cardiac Arrhythmias or Muscle Weakness  KCl IV (cardiac monitor)  PO K - Depend of etiology  Hypophoshatemia = KPO4  Metabolic acidosis = KCl  Renal tubular acidosis = K citrate
  • 35. Hyperkalemia  Differential Diagnosis  Pseudohyperkalemia - from blood hemolysis  Metabolic Acidosis  Chronic Renal Failure  Congenital Adrenal Hyperplasia  Females = Usually Dx at birth - Ambiguous Genitalia  Males = Dehydration, hyponatremia, hyperkalemia  Medications  ACE inhibitors and NSAID’s
  • 36. Hyperkalemia  Diagnosis:  Symptoms  Cardiac Arrhythmias  Paresthesias  Muscle weakness or paralysis  ECG  Peaked T waves  Short QT interval (K>6 mEq)  Depressed ST segment  Wide QRS (K>8 mEq)
  • 37. Hyperkalemia  Management  Close cardiac monitoring  Life -threatening hyperkalmia  Intravenous Calcium - rapid onset, duration< 30 min  NaHCO3 or glucose and insulin  Ion exchange resins  Sodium polystyrene sulfonate (Kayexelate)  PO or Enema  Hemodyalisis