H pylori role in ulcer

1. Laiba Mumtaz 60

2. Sub-Topics:
01 Causes
02 Pathology
03 Regimes
04 Revision

3. 01
Causes
• Poverty • Limited
education
• Household
crowding
• Poor
sanitation

4. Spiral shaped bacilli present in
almost all biopsies of patients with
gastric ulcers and chronic
gastritis..
H. pylori

5. Microscope:

6. Urease
Flagella
Adhesion
Toxins

7. 02 Pathophysiology

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May progress to involve
gastric body and fundus
Limited to antrum
Reduced parital cell
mass and acid
secretion.
Hypergastrinemia
Intestinal metaplasia
Gastric cancer

10. 03 Treatment Regimes

11. To eradicate the
organism
To heal the
ulcer

12. Triple therapy

13. Twice daily
500mg twice daily

14. Sequencial
Treatment

15. Day 1-5
_Proton pump inhibitor twice daily.
_1g Amoxicillin twice daily.
Day 6-10
_Proton pump inhibitor twice daily.
_Clarithromycin 500mg twice daily.
_Tinidazole 500mg twice daily

17. THANKS