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Let’s Revisit Awake
Intubation
Clifford Gonzales
CRNA, PhD
Wake Forest School of Medicine
Nurse Anesthesia Program
Objectives
• After the presentation, participants will be
able to:
 Identify physical assessments for
ventilation and tracheal intubation.
 Describe the innervation of the
airway.
 State the modalities of anesthetizing
the airway.
Closed Claims
• 1984- ASA Closed Claims Project
Anesthesiol. 1999; 91:552-556
Closed Claims
• 1970-2007 Closed claims analysis
Best Pract Res Clin Anaesthesiol. 2011; 25:263-276
0%
10%
20%
30%
Esophagealintubation
Inadequateoxygenation/ventilation
DifficultIntubation
Aspiration
Proportionofrespiratoryclaimsintimeperiod(%)
1970-1989
1990-2007
Closed Claims
1980-2011 Closed Claims Analysis
• 10,093 closed claims
• Airway injuries from general
anesthesia.
https://depts.washington.edu/asaccp/pubs/herring-jc-posner-kl-domino-kb-airway-injuries-associated-
general-anesthesia-closed-claims
Airway Management
Closed Claims
1980-2011 Closed Claims Analysis
0%
10%
20%
30%
40%
50%
Difficult Intubation (DI) Pharyngeal/Esophageal Perforation (P/EP)
ProportionofAirwayInjures
1980-1999
2000-2011
https://depts.washington.edu/asaccp/pubs/herring-jc-posner-kl-domino-kb-airway-injuries-associated-general-anesthesia-
closed-claims
Closed Claims
Limitations of closed claims
Inaccurate numerator and denominator
Geographical representations
Retrospective studies
Closed Claims
Lessons from closed claims
Securing an airway is a team effort
Avoid haste with preparation
(assessment, planning, communication)
Anatomy and physiology,
pharmacological, and equipment
knowledge needs to be current
Airway Assessment
Table 4a: Comparison of various predictive tests
Assessment Sensitivity (%) Specificity (%) PPV (%) NPV (%)
IIG 13.43 98.31 56.25 87.50
HNM 07.46 93.95 16.67 86.22
MMT 70.15 61.02 22.60 92.65
TMD 07.46 98.06 38.46 86.72
RHTMD 71.64 92.01 59.26 95.24
ULBT 74.63 91.53 58.82 95.70
IIG=Inter-incisor gap; HNM=Head and neck movement; MMT=Modified
mallampatti test; TMD=Thyromental distance; RHTMD=Ratio of height to
thyromental distance; ULBT=Upper lip bite test
J Aenesthesiol Clin Pharmacol, 2013, 29(2): 191-195
Airway Assessment
Assessment of ability to mask ventilate
M
O
A
N
S
Mask seal
Obese
Age
Nose, no teeth, neck mobility
stiffness
Airway Assessment
Assessment of ability to intubate
L
E
M
O
N
Look externally
Evaluate (TMD, RHTTMD, ULBT)
Mallampati
Obstruction
Neck mobility
Multivariate assessment to predict DI
Difficulty Airway Algorithm
• ASA Difficult Airway Algorithm
• 1. Assess the likelihood and clinical impact of basic management problems:
• Difficulty with patient cooperation or consent
• Difficult mask ventilation
• Difficult supraglottic airway placement
• Difficult laryngoscopy
• Difficult intubation
• Difficult surgical airway access
• 2. Actively pursue opportunities to deliver supplemental oxygen throughout the
process of difficult airway management.
• 3. Consider the relative merits and feasibility of basic management choices:
• Awake intubation vs. intubation after induction of general anesthesia
• Non-invasive technique vs. invasive techniques for the initial approach to intubation
• Video-assisted laryngoscopy as an initial approach to intubation
• Preservation vs. ablation of spontaneous ventilation
Anesthesiology 2013; 118:251-270
Difficulty Airway Algorithm
• ASA Difficulty Airway Algorithm
Anesthesiology 2013; 118:251-270
Difficulty Airway Algorithm
• Unanticipated Difficulty Airway Algorithm
Brit J of Anesthet, 2015; 115(6):827-848
Awake Intubation
• Indications
 Co-morbidities (cervical conditions,
intolerance to apnea, etc.)
 Risk of aspirations
 Difficult airway assessment
 Emergency
Awake Intubation
• Explanation to patient
• Pharmacological
• Equipment
• Personnel
Awake Intubation
• Pharmacological
 Antisialagogue
 Dilators
 Sedation
 Topical anesthesia
 Emergency
Awake Intubation
• Equipment
 Airway visualization
 Adjuncts
 Monitors
 Emergency
Awake Intubation
• Personnel
 Other anesthesia providers
 Surgeon/s
 Nurses
Awake Intubation
• Various local anesthetics (LA) can be used
for anesthetizing the airway.
• Lidocaine has an advantage because of:
 Availability of different formularies
and preparation.
 Wider margin of safety
Awake Intubation
Airway innervation
• Nasopharynx- Trigeminal nerve
(opthalmic and maxillary branch)
• Oropharynx- CNIX
(Glossopharyngeal nerve)
• Laryngopharynx- superior
laryngeal nerve
• Larynx and trachea- recurrent
laryngeal nerve
Common Methods of Anesthetizing
the Airway
Nasopharynx
• ½ in of lidocaine 5% at each nares (50mg)
OR
• 2 ml Lidocaine 4% aerosol spray (80mg)
Common Methods of Anesthetizing
the Airway
Oropharynx
•Apply 2 inches of 5% Lidocaine
ointment on a tongue depressor
(200mg)
OR
• Instruct patient to gurgle 5 ml of
Lidocaine 4% topical solution (may
need to do this twice) (200 mg or
400mg)
Common Methods of Anesthetizing
the Airway
Oropharynx
OR
• Place ½ in. of 5% lidocaine at a cotton tip
applicator and apply it at the base of
palatoglossal arch (5 min each side) (100
mg)
OR
• Using a 22g spinal needle, administer 2% of
Lidocaine injection solution to both bases of
the palatoglossal arch (80mg)
Common Methods of Anesthetizing
the Airway
Laryngopharynx (Superior Laryngeal Nerve)
•Administer 5 ml of 4% lidocaine injection
solution via nebulization (200 mg)
OR
•Drip 5 ml of 2% lidocaine viscous solution to
the back of the patient’s tongue (1-2 min)
(200mg)
Common Methods of Anesthetizing
the Airway
Laryngopharynx (Superior Laryngeal Nerve)
OR
• Using a 23 G needle, administer 3 ml of
2% lidocaine injection solution at both
lateral sides of the neck between the
thyroid cartilage and hyoid bone (120mg).
Common Methods of Anesthetizing
the Airway
Recurrent Laryngeal Nerve
• Lidocaine nebulization may suffice
OR
• Using epidural cath through the fiberoptic,
5ml of lidocaine 4% to the trachea (200mg)
OR
• Using a 20 G needle, administer 5 ml of 4%
lidocaine injection solution to the
Cricothyroid membrane (200mg)
Awake Intubation
Calculation of lidocaine total
administered dose:
1. Nasopharynx (ointment)= 50mg
2. Glossopharyngeal nerve= 80mg
3. Superior Laryngeal nerve= 120mg
4. Recurrent Laryngeal nerve=200mg
Total without nasopharynx = 400mg
Total with nasopharynx = 450mg
Awake Intubation
Lidocaine toxicity
• Legendary: 5mg/kg
• Normal therapeutic range for ventricular
arrythmias: 2-5mcg/ml
• Various pharmacological factors affect
lidocaine plasma level
Awake Intubation

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Awake intubation distribution

  • 1. Let’s Revisit Awake Intubation Clifford Gonzales CRNA, PhD Wake Forest School of Medicine Nurse Anesthesia Program
  • 2. Objectives • After the presentation, participants will be able to:  Identify physical assessments for ventilation and tracheal intubation.  Describe the innervation of the airway.  State the modalities of anesthetizing the airway.
  • 3. Closed Claims • 1984- ASA Closed Claims Project Anesthesiol. 1999; 91:552-556
  • 4. Closed Claims • 1970-2007 Closed claims analysis Best Pract Res Clin Anaesthesiol. 2011; 25:263-276 0% 10% 20% 30% Esophagealintubation Inadequateoxygenation/ventilation DifficultIntubation Aspiration Proportionofrespiratoryclaimsintimeperiod(%) 1970-1989 1990-2007
  • 5. Closed Claims 1980-2011 Closed Claims Analysis • 10,093 closed claims • Airway injuries from general anesthesia. https://depts.washington.edu/asaccp/pubs/herring-jc-posner-kl-domino-kb-airway-injuries-associated- general-anesthesia-closed-claims
  • 6. Airway Management Closed Claims 1980-2011 Closed Claims Analysis 0% 10% 20% 30% 40% 50% Difficult Intubation (DI) Pharyngeal/Esophageal Perforation (P/EP) ProportionofAirwayInjures 1980-1999 2000-2011 https://depts.washington.edu/asaccp/pubs/herring-jc-posner-kl-domino-kb-airway-injuries-associated-general-anesthesia- closed-claims
  • 7. Closed Claims Limitations of closed claims Inaccurate numerator and denominator Geographical representations Retrospective studies
  • 8. Closed Claims Lessons from closed claims Securing an airway is a team effort Avoid haste with preparation (assessment, planning, communication) Anatomy and physiology, pharmacological, and equipment knowledge needs to be current
  • 9. Airway Assessment Table 4a: Comparison of various predictive tests Assessment Sensitivity (%) Specificity (%) PPV (%) NPV (%) IIG 13.43 98.31 56.25 87.50 HNM 07.46 93.95 16.67 86.22 MMT 70.15 61.02 22.60 92.65 TMD 07.46 98.06 38.46 86.72 RHTMD 71.64 92.01 59.26 95.24 ULBT 74.63 91.53 58.82 95.70 IIG=Inter-incisor gap; HNM=Head and neck movement; MMT=Modified mallampatti test; TMD=Thyromental distance; RHTMD=Ratio of height to thyromental distance; ULBT=Upper lip bite test J Aenesthesiol Clin Pharmacol, 2013, 29(2): 191-195
  • 10. Airway Assessment Assessment of ability to mask ventilate M O A N S Mask seal Obese Age Nose, no teeth, neck mobility stiffness
  • 11. Airway Assessment Assessment of ability to intubate L E M O N Look externally Evaluate (TMD, RHTTMD, ULBT) Mallampati Obstruction Neck mobility Multivariate assessment to predict DI
  • 12. Difficulty Airway Algorithm • ASA Difficult Airway Algorithm • 1. Assess the likelihood and clinical impact of basic management problems: • Difficulty with patient cooperation or consent • Difficult mask ventilation • Difficult supraglottic airway placement • Difficult laryngoscopy • Difficult intubation • Difficult surgical airway access • 2. Actively pursue opportunities to deliver supplemental oxygen throughout the process of difficult airway management. • 3. Consider the relative merits and feasibility of basic management choices: • Awake intubation vs. intubation after induction of general anesthesia • Non-invasive technique vs. invasive techniques for the initial approach to intubation • Video-assisted laryngoscopy as an initial approach to intubation • Preservation vs. ablation of spontaneous ventilation Anesthesiology 2013; 118:251-270
  • 13. Difficulty Airway Algorithm • ASA Difficulty Airway Algorithm Anesthesiology 2013; 118:251-270
  • 14. Difficulty Airway Algorithm • Unanticipated Difficulty Airway Algorithm Brit J of Anesthet, 2015; 115(6):827-848
  • 15. Awake Intubation • Indications  Co-morbidities (cervical conditions, intolerance to apnea, etc.)  Risk of aspirations  Difficult airway assessment  Emergency
  • 16. Awake Intubation • Explanation to patient • Pharmacological • Equipment • Personnel
  • 17. Awake Intubation • Pharmacological  Antisialagogue  Dilators  Sedation  Topical anesthesia  Emergency
  • 18. Awake Intubation • Equipment  Airway visualization  Adjuncts  Monitors  Emergency
  • 19. Awake Intubation • Personnel  Other anesthesia providers  Surgeon/s  Nurses
  • 20. Awake Intubation • Various local anesthetics (LA) can be used for anesthetizing the airway. • Lidocaine has an advantage because of:  Availability of different formularies and preparation.  Wider margin of safety
  • 21. Awake Intubation Airway innervation • Nasopharynx- Trigeminal nerve (opthalmic and maxillary branch) • Oropharynx- CNIX (Glossopharyngeal nerve) • Laryngopharynx- superior laryngeal nerve • Larynx and trachea- recurrent laryngeal nerve
  • 22. Common Methods of Anesthetizing the Airway Nasopharynx • ½ in of lidocaine 5% at each nares (50mg) OR • 2 ml Lidocaine 4% aerosol spray (80mg)
  • 23. Common Methods of Anesthetizing the Airway Oropharynx •Apply 2 inches of 5% Lidocaine ointment on a tongue depressor (200mg) OR • Instruct patient to gurgle 5 ml of Lidocaine 4% topical solution (may need to do this twice) (200 mg or 400mg)
  • 24. Common Methods of Anesthetizing the Airway Oropharynx OR • Place ½ in. of 5% lidocaine at a cotton tip applicator and apply it at the base of palatoglossal arch (5 min each side) (100 mg) OR • Using a 22g spinal needle, administer 2% of Lidocaine injection solution to both bases of the palatoglossal arch (80mg)
  • 25. Common Methods of Anesthetizing the Airway Laryngopharynx (Superior Laryngeal Nerve) •Administer 5 ml of 4% lidocaine injection solution via nebulization (200 mg) OR •Drip 5 ml of 2% lidocaine viscous solution to the back of the patient’s tongue (1-2 min) (200mg)
  • 26. Common Methods of Anesthetizing the Airway Laryngopharynx (Superior Laryngeal Nerve) OR • Using a 23 G needle, administer 3 ml of 2% lidocaine injection solution at both lateral sides of the neck between the thyroid cartilage and hyoid bone (120mg).
  • 27. Common Methods of Anesthetizing the Airway Recurrent Laryngeal Nerve • Lidocaine nebulization may suffice OR • Using epidural cath through the fiberoptic, 5ml of lidocaine 4% to the trachea (200mg) OR • Using a 20 G needle, administer 5 ml of 4% lidocaine injection solution to the Cricothyroid membrane (200mg)
  • 28. Awake Intubation Calculation of lidocaine total administered dose: 1. Nasopharynx (ointment)= 50mg 2. Glossopharyngeal nerve= 80mg 3. Superior Laryngeal nerve= 120mg 4. Recurrent Laryngeal nerve=200mg Total without nasopharynx = 400mg Total with nasopharynx = 450mg
  • 29. Awake Intubation Lidocaine toxicity • Legendary: 5mg/kg • Normal therapeutic range for ventricular arrythmias: 2-5mcg/ml • Various pharmacological factors affect lidocaine plasma level