13. 12
Placebo
20mg
40mg
PG-YBOCS Urges
10
8
p=.027
6
4
2
4 6 8 10
Visit

14. 1.0
.9
.8
Naltrexone /
Proportion Nonrelapsed
Asp40 Allele (A/G, G/G)
.7
Naltrexone
.6
Asn40 Allele (A/A)
.5
Placebo /
Asp40 Allele (A/G, G/G)
.4
Placebo /
Asn40 Allele (A/Al)
.3
.2
.1
0.0
0
14
28
42
56
70
84
Days

15. Analysis of Maximum Likelihood Estimates
(N=282)
Variable Parameter Standard Chi- Pr>ChiSq Hazard
Estimate Error Square Ratio
FH-AUD 0.55 0.24 7.53 0.006 1.74
Baseline urges were significantly associated with response to
higher doses of opiate antagonists (i.e. nalmefene 50mg or
100mg or naltrexone 100mg or 150mg) (parameter estimate =
1.77; SE= 0.84; Wald 2 =4.41; p= .036; HR= 5.86; HR 95%
CI=1.12-30.6

18. N-Acetyl Cysteine: 12-Week Open-Label
56% reduction in urges; 57% reduction in total gambling
symptoms

22. Visit 1 Visit 6 p-value
PG-YBOCS total
score 21.8 8.9 <.001
Responder, n (%) n/a 18 <.001
(62.1)
Dollars lost per week 743 309 <.001
Hours gambled per
week 10.4 4.0 <.001

23. PG B v E PG B v C PG E v C
T P t p t p
IDED total
2.20 0.037 2.09 0.041 1.06 0.294
errors

24. Lexapro Treatment of Anxious Gamblers

25. *
*
*
* p<.05
Hollander et al, 2002