NanoMarkets believes that medical ceramics represents a major opportunity in the medical materials market over the next few years. They have already established themselves in orthopedic and dental implants; providing a multitude of patients with problem free bone and tooth replacements. Increasingly, prostheses for hip replacement consist of metal ceramic composites. NanoMarkets also believes that bioceramics and their metal composites have a great potential to heal long segmental bone defects and that in the future, orthopedic implants will rely on scaffold-guided bone tissue. The primary goal of this report is to identify the market opportunities in the medical ceramics sector over the next eight years. This report not only includes a granular forecast and analysis of the more established medical ceramics markets, but also gives a comprehensive analysis of medical nano-ceramics especially in terms of enhancing the healing properties of implantable materials. This report discusses the commercial aspects of all the current trends in medical ceramics and the numerous applications in which they can be used. The report also profiles key suppliers and analyzes the complete supply chain for medical ceramics. For the firms covered we discuss their strategies and needs along with their strengths and weaknesses.

1. NanoMarkets Report
Worldwide Medical Ceramics Markets—
Markets
2013
Nano-655
Published October 2013

2. Markets—
Worldwide Medical Ceramics Markets—2013
SUMMARY
NanoMarkets believes that medical ceramics represents a major opportunity in the
medical materials market over the next few years. They have already established
themselves in orthopedic and dental implants; providing a multitude of patients with
multitude
problem-free bone and tooth replacements.
ree
Increasingly, prostheses for hip
replacement consist of metal ceramic composites. NanoMarkets also believes that
bioceramics and their metal composites have a great potential to heal long
segmental bone defects and that in the future, orthopedic implants will rely on
scaffold-guided bone tissue.
The primary goal of this report is to identify the market opportunities in the medical
ceramics sector over the next eight years. This report not only includes a granular
forecast and analysis of the more established medical ceramics markets, but also
gives a comprehensive analysis of medical nano ceramics especially in terms of
nano-ceramics
enhancing the healing properties of implantable materials.
This report discusses the commercial aspects of all the current trends in medical
of
ceramics and the numerous applications in which they can be used. The report also
profiles key suppliers and analyzes the complete supply chain for medical ceramics.
For the firms covered we discuss their strategies and needs along with their
and
strengths and weaknesses.
Table of Contents
Executive Summary
E.1 Opportunities for Medical Device and Implants Firms
E.2 Opportunities for the Healthcare Sector
E.3 Opportunities for Materials Firms
E.4 Firms to Watch in Medical Ceramics
E.5 Summary of Eight-Year Forecasts of Medical Ceramics
Year
Chapter One: Introduction
1.1 Background to this Report
1.2 Objective and Scope of this Report
1.3 Methodology of this Report
1.3.1 Forecasting Methodology
Page | 1

3. 1.3.2 Plan of Report
Chapter Two: Medical Ceramics: Current Use and Major Technology Trends
2.1 Ceramic Composites: Key Medical
Medical-Related Trends
2.1.1 Ceramic Compositions and Processes
2.1.2 New Production Methods Increase Application of Medical Ceramics
2.1.3 Ceramic Injection Molding Produces Small High Precision and Intricate
Implants
2.2 Bioactive ceramic coatings
2.2.1 Calcium Phosphate Coatings
2.2.2 Hydroxyapatite coatings
2.2.3 Glass ceramic coatings
2.2.4 Diamond-Like Carbon Coatings
Like
2.3 Alumina and Zirconia Ceramics
2.4 Future Advances with Piezo
Piezo-ceramics and Sensors
2.5 Current and Future Applications of Medical Nano
Nano-Ceramics
2.6 Predominantly Glass and Partially Filled Glass Ceramics
2.7 Key Points Made in this Chapter
Chapter Three: Applications Markets for Medical Ceramics
3.1 Major Factors Impacting the Medical Ceramics Market
3.1.1 Clinical Trials
3.1.2 Environmental Regulations
3.1.3 Intellectual Property Issues
3.1.4 Globalization and Trade Barriers
3.1.5 Research and Development
3.2 Medical Ceramics in Orthopedics
3.2.1 Total Hip and Joint Replacements
1
Page | 2

4. 3.2.2 Ceramic composites as Artificial Joint Systems and Bioglass Implantable
Components
3.2.3 Regeneration of Bone Tissue Using Scaffold Guided Tissue Engineering
Scaffold-Guided
3.2.4 Other Orthopedics Applications
3.2.5 Eight-Year Forecast of Medical Ceramics in Orthopedics, by Material and
ecast
Medical Procedure
3.2.6 Notable Companies and Other Organizations Influencing the Use of Ceramics
in Orthopedics
3.3 Medical Ceramics in Dentistry
3.3.1 Main Applications for Medical Ceramics in Dentistry
3.3.2 Eight-Year Forecast of Medical Ceramics in Dentistry by Material and Dental
Year
Procedure
3.3.3 Notable Companies and Other Organizations Influencing the Use of Ceramics
in Dentistry
3.4 Medical Ceramics in Medical Equipment
3.4.1 Surgical Equipment
3.4.2 Diagnostic Equipment
3.4.3 Ceramics in Implantable Electronic Devices
3.4.4 Eight-Year Forecast of Medical Equipment, by Material and Equipment Type
Year
3.4.5 Notable Companies and Other Organizations Influencing the Use of Ceramics
in Medical Equipment
3.5 Injectable Ceramic and Ceramic Composites for In Vivo Regeneration of Hard
and Soft tissues
3.5.1 Eight-Year Forecast of Medical Ceramics in Regeneration Procedures
Year
3.5.2 Notable Companies and Other Organizations Influencing the Use of Ceramics
in Regeneration Procedures
Chapter Four: Summary of Forecasts and Geographical Analysis
4.1 Summary of Eight-Year Market Forecasts
Year
4.1.1 Summary by Procedure
4.1.2 Summary by Type of Equipment/Implant
Page | 3

5. 4.1.3 Summary by Type of Medical Ceramic Material
4.2 Markets for Medical Ceramics in the U
rkets
U.S.
4.2.1 Regulatory Environment
4.2.2 Trends and Opportunities
4.3 Eight-Year Forecasts of Markets for Medical Ceramics in Europe
Year
4.3 Markets for Medical Ceramics in Europe
4.3.1 Regulatory Environment
4.3.2 Trends and Opportunities
pportunities
4.3.3 Eight-Year Forecasts of Markets for Medical Ceramics in Europe
Year
4.4 Markets for Medical Ceramics in Japan
4.4.1 Regulatory Environment
4.4.2 Trends and Opportunities
4.4.3 Eight-Year Forecasts of Markets for Medical Ceramics in Japan
Year
4.5 Markets for Medical Ceramics in China
4.5.1 Regulatory Environment
4.5.2 Trends and Opportunities
4.5.3 Eight-Year Forecasts of Markets for Medical Ceramics in China
Year
4.6 Other Notable National and Regional Markets for Medical Ceramics
4.6.1 Eight-Year Forecasts of Markets for Medical Ceramics in Other Parts of the
casts
World
RELATED REPORTS
2013Worldwide Medical Polymer Markets: 2013-2020
Page | 4

6. Chapter One: Introduction
1.1 Background to this Report
1.1.1 Two Principal Sectors of the Medical Ceramics Market
In the past, medical ceramics were represented by ceramic and clay implants that remained inert
in the host and acted as scaffolds or supports. Today the scenario has changed remarkably due
e
to the introduction of an entirely new generation of bioceramics. These implants are, amazingly,
structurally and functionally compatible with living tissue in the human body and contribute to the
development of new tissue. Over the past two decades there has been tremendous improvement
.
decades,
in the performance of these bioceramics, and technology advances have created a huge market
for ceramics in the medical sector.
The two key markets for medical ceramics are:
•
Implantable bioceramics which consist of medical devices and implants that are on the
e bioceramics,
market as tooth and bone replacements. Bone and joint replacements are essentially
metal and ceramic composites, whereas dental implants are mostly made of all-ceramic
al
whereas
all
systems. Bioceramics are a huge success as implantable materials because they are
oceramics
bioactive in their natural compositions and can be fabricated into various composites with
metals, both natural and synthetic polymers, carbon fibers, and most recently, carbon
nanotubes.
•
Medical equipment including analytical and scientific instrumentation; ceramics are
equipment,
instrumentation
primarily used in analytical, diagnostic, vision, and therapy systems.
Although there are a few risks and ambiguities regarding the use of implants and medical devices
an
based on ceramics, NanoMarkets certainly believes that the market for implantable bioceramics
will continue to grow in the future. This growth can possibly be converted into profitable
businesses by the companies manufacturing the medical ceramic devices and the firms that
supply the necessary raw materials.
1.1.2 Implantable Bioceramics Market Dominated by Tooth and Bone
y
Replacements
Biocompatibility and resistance to wear have made ceramic materials ideal for a range of medical
applications, from artificial joints to electronic sensors, stimulators and drug delivery devices.
stimulators,
Alumina and zirconia, among other ceramics, have been successful in withstanding the hostile
environment of the human body. The implantable bioceramics market primarily consists of two
et
segments: tooth and bone replacements.
Dental implants: The dental consumables segment includes crown /bridges, implants,
crowns/bridge
orthodontics, impressive materials, composites, endodontics, adhesives and cements, while the
adhesives,
cement
dental equipment segment is composed of large equipment such as autoclaves, sterilizers,
uipment
equipment,
chairs, communication systems, compressors, cuspidors and digital imaging systems. Small
cuspidors,
system
equipment, including amalgam removal system , amalgamators, hand piece cleaners, lab
systems,
cleaner
equipment, duplicators, and ultrasonic cleaners, also fall into this product segment.
Page | 5

7. The leading multinational manufacturers account for approximately two thirds of the global implant
market and pursue premium strategies. The remainder of the market is ve fragmented,
very
consisting of several hundred competitors, the majority of which have a local country or regional
focus.
The competition in the global dental implant market is intense with only a few large players,
intense,
Page | 6
including Nobel Biocare, Straumann, Dent
Dentsply, and Zimmer. The main drivers of the global dental
market include low dental implant penetration rates and an increasing worldwide elderly
population. Another factor that drives the dental market is longer life expectancies, because an
expectanc
increase in life expectancy results in a more elderly population. Increasing consumer incomes and
e
income
increasing urban population are other major factors that are boosting the dental market.
populations
Bone implants: Alumina and zirconia are the main ceramic materials for bone implants, largely
implan
due to their mechanical strength and chemical inertness. Morgan Technical Ceramics (MTC) is
one of the globally renowned medical ceramic manufacturers that has substantial experience in
developing clinically proven ceramic joints using alumina and zirconia.
MTC’s Vitox AMC alumina matrix composite bioceramic material used in hip joints has been
shown to have exceptionally low wear rates compared with alternative materials. It is therefore a
dependable solution that does not have the potential health risks associated with metal hip joints,
ealth
and it is longer lasting, thus enabling patients to continue to lead active lifestyles.
Medical-grade silicon nitride ceramics have good potential to find applicability in the spinal and
grade
arthroplasty segments.
Ceramics are also used in bone tissue engineering because of their osteoinductive and
biocompatible properties. Scaffolds that typically act as engineered bone grafts can be used in
several specialty applications such as bone regeneration and wound healing.
applications,
1.1.3 Wide Use o Ceramics In Biomedical Equipment
of
Ceramics are widely used in biomedical equipment, such as ultrasound machines, point-of-care
systems, medical test equipment and imaging instruments. MTC has, for example, launched its
equipment,
,
piezoceramic objective focusing device that provides the millisecond responsiveness essential for
jective
DNA research. Piezoceramics have become the premium choice for medical device
manufacturers for the execution of accurate positioning and precise movements.
Because the number of people that need implants is always on the rise, demand for implantable
er
bioceramics and composites continue to increase, while the number of ceramic parts used in
continues
biomedical equipment depends on the number of pieces of equipment manufactured and their
the
utility. Thus, NanoMarkets believes that the demand for implantable bioceramics materials will be
higher than that for ceramic components used in medical equipment.
1.1.4 Market Opportunities for Implantable Bioceramics Materials
Dental consumables represent the largest segment of the dental care industry, followed by dental
esent
industry,
equipment. In other words, implantable bioceramics consisting of tooth and bone replacements
,
ooth
are in great demand and account for most of the market while the tools and instruments used
market,
during implantation account for just a small part of the overall market.

8. The scenario described above suggests that not only the number of small implants used by the
global population is growing and likely to continue to grow, but also the magnitude of sales are
steadily increasing. Due to this steady growth in the small implants market, NanoMarkets expects
the bioceramics materials market to continue to grow over the next eight years.
In this growing market, bioceramics materials suppliers will have expanded opportunities to
Page | 7
generate new business revenues from both natural substrates and composites and novel
manufacturing technologies such as injection molding and electro-spinning. However, the
technologies,
spinning.
significant contributors to clinical success will be mat
materials that are bioactive, improve lifetimes,
,
and reduce manufacturing costs.
The implant manufacturing giants like Nobel Biocare, Strauman and Zimmer offer end-to-end
Strauman,
solutions to patients that receive bone and joint replacements, from computed tomography (CT)
s,
tomograph
scans to the actual devices More than 20 percent of all of the prosthetic elements (tooth-based
s.
(tooth
and implant-based) were produced using computer-aided design/computer-aided manufacturing
)
aided
(CAD/CAM) in 2012. Although the majority of prosthetic elements are still made by hand, the
elements
share of dentists using CAD
CAD/CAM prosthetic elements continues to increase.
1.1.5 Nanoceramic Composites Promising But Risky
eramic Composites:
Ceramic materials fabricated in the form of nano sized particles show promise in bone tissue
nano-sized
regeneration applications. I fact, many in vitro studies have proved beyond a doubt that boneIn
forming cells called osteoblasts have proliferated on substrates with nanoceramic particles and
coatings.
However, when the ceramics are formed into composites with carbon nanotubes (CNTs),
cytotoxicity has been observed in some experiments. In addition, nanoceramic polymer
anoceramic
composites with amine and amide groups may lead to the accumulation of toxic debris that can
evoke inflammatory and/or immune responses and ultimately lead to the rejection of the
ultimately
composite when implanted in a human host. Moreover, the rejection of the implant sometimes can
lead to sepsis or septic shock.
Therefore, while nanoceramic composites have potential in the future as implants and medical
devices, NanoMarkets believes that key questions about their biocompatibility and bioactive
properties must first be addressed before that potential can be realized.
Major implant manufacturers must conduct thorough research studies and, more importantly,
ers
appropriate clinical trials before implant and prostheses containing nanoceramic composites are
ppropriate
implants
s
released to the market.
In addition, NanoMarkets has observed that the number of companies offering nanoceramics is
growing. Therefore, firms that simply offer acceptable clinical solutions, and not clinically
significant advantages, will only be able to compete on price. However, if they can offer a price
,
advantage, because most clinicians are price sensitive, the clinicians may gravitate to the newer
lower-cost substitute implants.
1.2 Objectives and Scope of This Report
This report is the latest NanoMarkets report on opportunities in the medical ceramics markets.

9. NanoMarkets has been providing comprehensive industry analysis of the medical ceramics
markets for several years, and this report presents information on the existing markets and
emerging opportunities in the field. Th
Thus, the goal of this report is to analyze and forecast the
prospects for bioceramic materials and implants in the coming eight years.
We have extensively studied the market dynamics in the medical ceramics materials sector and
ied
Page | 8
analyzed what we perceive to be the different opportunities that are emerging for materials used
in both implantable bioceramics and ceramics. The opportunities are summarized in detailed
These
forecasts both in revenue and volume terms for all of the predominantly used materials in medical
ceramics, as well as the latest substrates and composites
composites.
1.3 Information Sources and Methodology for This Report
NanoMarkets has conducted industry research on medical ceramics and bioceramic materials,
s
and this report is written on the basis of ongoing discussions with key players throughout the
players
industry. In addition, a cumulative analysis of the industry, including the strengths and
weaknesses of the major players was considered when writing this report.
players,
Additional information for this report was drawn from the Internet, commercial databases, trade
tradepress articles, press releases, industry reports and market updates, and corpora literature in
corporate
order to further understand the activity that is taking place in th medical ceramics market space.
the
In addition, this report is entirely international in scope. We have conducted interviews worldwide
his
in order to collect information for the report and arrived at the worldwide forecasts without
focusing on any specific geographic areas.
The medical ceramics market forecasts presented in this report are drawn from our estimates of
both material shipments and manufacturing capacities. We also consider the success rates of the
implants and estimate the needs of major medical ceramics producers with respect to their
materials suppliers. The materials forecasts are broken down by material type and functionality
material
and fabrication process. The forecasting methods followed and assumptions used when preparing
the forecasts in this report are explained in more detail in Chapter Four.
1.4 Plan of This Report
Chapter Two discusses the major ceramics technologies and the various current applications for
bioceramics. An explanation of the existing market status with a few insights into the changes that
should occur in the market in order to make it more dynamic and profitable is also provided. This
provided
analysis forms the basis for our forecasts, which are presented later in Chapter Four of the report.
Chapter Three examines the applications for medical ceramics and reviews the major factors
m
influencing the medical ceramics market with a focus on recent developments in intellectual
eramics
nt
property (IP), acquisitions, and consolidation. In this chapter, we analyze the R&D strategies of
,
some of the major players in this space with respect to ceramics for use in implants, injectable
ceramics, and scaffold-guided bone tissue engineering on bioceramic scaffolds.
guided
We also provide a comprehensive account of notable companies and other organizations
o
influencing the use of ceramics in implants, regenerative medicine, and medical equipment and
eramics
present our detailed eight
ight-year forecasts of implantable bioceramics and ceramics used in
medical instrumentation. The forecasts are organized primarily by application and functionality
functionality.

10. In Chapter Four, we provide summary eight-year forecasts of the bioceramics materials sector
secto
based on application, functionality, and type of material, with considerable focus on the
processing and fabrication technologies. We also present our eight-year forecasts for key
year
geographies, including the U
U.S., Europe, Japan, China, and the rest of the world.
Page | 9