Presented at the joint International Eczema Council and National Alopecia Areata Foundation Symposium, "Atopic Dermatitis and Alopecia Areata: Comparison and Contrast”, held during the 2019 Annual American Academy of Dermatology meeting in Washington, DC to explore the similarities and differences between these two common but complex skin diseases and the implications from bench to bedside.
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Therapeutic advances in alopecia areata
1. Therapeutic Advances in Alopecia Areata
Brett King, MD, PhD
Associate Professor of Dermatology
Yale University School of Medicine
2. Disclosures
• Off-label use of medications will be discussed
• I have received honoraria and/or consulting fees from:
Aclaris Therapeutics, Concert Pharmaceuticals, Dermavant
Sciences, Eli Lilly, Pfizer
• I am a clinical trial investigator for:
Concert Pharmaceuticals, Eli Lilly, Pfizer
• I am on a speaker bureau for:
Pfizer, Regeneron, Sanofi Genzyme
3. Alopecia Areata: Treatment
• Intralesional corticosteroids
• Topical corticosteroids
• Topical immunotherapy (e.g. diphenylcyclopropenone, squaric acid)
• Topical minoxidil
• Oral corticosteroids
• Methotrexate
• Cyclosporine
* No reliably effective therapies, especially for severe disease
Strazzulla LC, et al. Alopecia areata: An appraisal of new treatment approaches and overview of current therapies. J Am Acad Dermatol. 2018;78(1):15-24.
7. CytokineSignalingisMediated
byJAK-STATPathway
Janus kinase (JAK) family consists of JAK 1,
JAK 2, JAK 3, and Tyrosine Kinase 2 Vitiligo
cytokine: IFN-g
JAK 1/2
AA
cytokines:
IL-15, IFN-g
JAK 1/2/3
JAK inhibitorJAK inhibitor
Damsky W, King BA. J Am Acad Dermatol. 2017;76(4):736-744.
AD
cytokines: IL-4,
IL-13
JAK 1/3