The seminar will discuss the role of Wnt signaling in the pathogenesis of Alzheimer's disease. Wnt signaling is involved in critical developmental processes and adult tissue homeostasis. In the brain, Wnt signaling maintains synaptic structure and function and plays a role in long term potentiation. Exposure to beta-amyloid, a pathological feature of Alzheimer's, disrupts Wnt signaling proteins like frizzled, disheveled, and GSK-3beta, leading to neurodegeneration. Emerging evidence suggests activating Wnt signaling through Wnt ligands or related pathways could serve as a potential therapeutic approach for Alzheimer's disease.