phase 1 designs candidate screening drug development ind preclinical proof of concept maximum tolerated dose target identification target validation phase 3 phase 2 phase 1 lead development nda drug discovery drug research designs regulatory hts scales used for checking homogenity test for homogenity assumption for model bucher method indirect comparisons heterogenity software model random model nma direct comparison cochrane node splitting consistency test for heterogenity fixed model mixed comparisons inconsistency bias homogenity
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