Biology "B" / Ch42

LECTURE PRESENTATIONS
For CAMPBELL BIOLOGY, NINTH EDITION
Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson
© 2011 Pearson Education, Inc.
Lectures by
Erin Barley
Kathleen Fitzpatrick
Circulation and Gas Exchange
Chapter 42

Overview: Trading Places
• Every organism must exchange materials with its
environment
• Exchanges ultimately occur at the cellular level by
crossing the plasma membrane
• In unicellular organisms, these exchanges occur
directly with the environment

• For most cells making up multicellular organisms,
direct exchange with the environment is not
possible
• Gills are an example of a specialized exchange
system in animals
– O2 diffuses from the water into blood vessels
– CO2 diffuses from blood into the water
• Internal transport and gas exchange are
functionally related in most animals

Concept 42.1: Circulatory systems link
exchange surfaces with cells throughout
the body
• Diffusion time is proportional to the square of the
distance
• Diffusion is only efficient over small distances
• In small and/or thin animals, cells can exchange
materials directly with the surrounding medium
• In most animals, cells exchange materials with the
environment via a fluid-filled circulatory system

Gastrovascular Cavities
• Some animals lack a circulatory system
• Some cnidarians, such as jellies, have elaborate
gastrovascular cavities
• A gastrovascular cavity functions in both digestion
and distribution of substances throughout the body
• The body wall that encloses the gastrovascular
cavity is only two cells thick
• Flatworms have a gastrovascular cavity and a
large surface area to volume ratio

Figure 42.2
Circular
canal
Mouth
Radial canals 5 cm
(a) The moon jelly Aurelia, a cnidarian (b) The planarian Dugesia, a flatworm
Gastrovascular
cavity
Mouth
Pharynx
2 mm

Figure 42.2a
Circular
canal
Mouth
Radial canals 5 cm
(a) The moon jelly Aurelia, a cnidarian

Figure 42.2b
(b) The planarian Dugesia, a flatworm
Gastrovascular
cavity
Mouth
Pharynx
2 mm

Evolutionary Variation in Circulatory
Systems
• A circulatory system minimizes the diffusion
distance in animals with many cell layers

General Properties of Circulatory Systems
• A circulatory system has
– A circulatory fluid
– A set of interconnecting vessels
– A muscular pump, the heart
• The circulatory system connects the fluid that
surrounds cells with the organs that exchange
gases, absorb nutrients, and dispose of wastes
• Circulatory systems can be open or closed, and
vary in the number of circuits in the body

Open and Closed Circulatory Systems
• In insects, other arthropods, and most molluscs,
blood bathes the organs directly in an open
circulatory system
• In an open circulatory system, there is no
distinction between blood and interstitial fluid, and
this general body fluid is called hemolymph

Figure 42.3
(a) An open circulatory system
Heart
Hemolymph in sinuses
surrounding organs
Pores
Tubular heart
Dorsal
vessel
(main heart)
Auxiliary
hearts
Small branch
vessels in
each organ
Ventral vessels
Blood
Interstitial fluid
Heart
(b) A closed circulatory system

Figure 42.3a
(a) An open circulatory system
Heart
Hemolymph in sinuses
surrounding organs
Pores
Tubular heart

• In a closed circulatory system, blood is
confined to vessels and is distinct from the
interstitial fluid
• Closed systems are more efficient at transporting
circulatory fluids to tissues and cells
• Annelids, cephalopods, and vertebrates have
closed circulatory systems

Figure 42.3b
(b) A closed circulatory system
Dorsal
vessel
(main heart)
Auxiliary
hearts
Small branch
vessels in
each organ
Ventral vessels
Blood
Interstitial fluid
Heart

Organization of Vertebrate Circulatory
Systems
• Humans and other vertebrates have a closed
circulatory system called the cardiovascular
system
• The three main types of blood vessels are arteries,
veins, and capillaries
• Blood flow is one way in these vessels

• Arteries branch into arterioles and carry blood
away from the heart to capillaries
• Networks of capillaries called capillary beds are
the sites of chemical exchange between the blood
and interstitial fluid
• Venules converge into veins and return blood
from capillaries to the heart
© 2011 Pearson Education, Inc.© 2011 Pearson Education, Inc.

• Arteries and veins are distinguished by the
direction of blood flow, not by O2 content
• Vertebrate hearts contain two or more chambers
• Blood enters through an atrium and is pumped
out through a ventricle

Single Circulation
• Bony fishes, rays, and sharks have single
circulation with a two-chambered heart
• In single circulation, blood leaving the heart
passes through two capillary beds before returning

Figure 42.4
(a) Single circulation (b) Double circulation
Artery
Heart:
Atrium (A)
Ventricle (V)
Vein
Gill
capillaries
Body
capillaries
Key
Oxygen-rich blood
Oxygen-poor blood
Systemic circuit
Systemic
capillaries
Right Left
A A
VV
Lung
capillaries
Pulmonary circuit

Figure 42.4a
(a) Single circulation
Artery
Heart:
Atrium (A)
Ventricle (V)
Vein
Gill
capillaries
Body
capillaries
Key
Oxygen-rich blood
Oxygen-poor blood

Double Circulation
• Amphibian, reptiles, and mammals have double
circulation
• Oxygen-poor and oxygen-rich blood are pumped
separately from the right and left sides of the heart

Figure 42.4b
(b) Double circulation
Systemic circuit
Systemic
capillaries
Right Left
A A
VV
Lung
capillaries
Pulmonary circuit
Key
Oxygen-rich blood
Oxygen-poor blood

• In reptiles and mammals, oxygen-poor blood flows
through the pulmonary circuit to pick up oxygen
through the lungs
• In amphibians, oxygen-poor blood flows through a
pulmocutaneous circuit to pick up oxygen
through the lungs and skin
• Oxygen-rich blood delivers oxygen through the
systemic circuit
• Double circulation maintains higher blood pressure
in the organs than does single circulation

Adaptations of Double Circulatory Systems
• Hearts vary in different vertebrate groups

Amphibians
• Frogs and other amphibians have a three-
chambered heart: two atria and one ventricle
• The ventricle pumps blood into a forked artery that
splits the ventricle’s output into the
pulmocutaneous circuit and the systemic circuit
• When underwater, blood flow to the lungs is nearly
shut off

Amphibians
Pulmocutaneous circuit
Lung
and skin
capillaries
Atrium
(A)
Atrium
(A)
LeftRight
Ventricle (V)
Systemic
capillaries
Systemic circuit
Key
Oxygen-rich blood
Oxygen-poor blood
Figure 42.5a

Reptiles (Except Birds)
• Turtles, snakes, and lizards have a three-
chambered heart: two atria and one ventricle
• In alligators, caimans, and other crocodilians a
septum divides the ventricle
• Reptiles have double circulation, with a pulmonary
circuit (lungs) and a systemic circuit

Figure 42.5b
Reptiles (Except Birds)
Pulmonary circuit
Systemic circuit
Systemic
capillaries
Incomplete
septum
Left
systemic
aorta
LeftRight
Right
systemic
aorta
A
V
Lung
capillaries
Atrium
(A)
Ventricle
(V)
Key
Oxygen-rich blood
Oxygen-poor blood

Mammals and Birds
• Mammals and birds have a four-chambered heart
with two atria and two ventricles
• The left side of the heart pumps and receives only
oxygen-rich blood, while the right side receives
and pumps only oxygen-poor blood
• Mammals and birds are endotherms and require
more O2 than ectotherms

Systemic circuit
Lung
capillaries
Pulmonary circuit
A
V
LeftRight
Systemic
capillaries
Mammals and Birds
Atrium
(A)
Ventricle
(V)
Key
Oxygen-rich blood
Oxygen-poor blood
Figure 42.5c

Figure 42.5
Amphibians Reptiles (Except Birds)
Pulmocutaneous circuit Pulmonary circuit
Lung
and skin
capillaries
Atrium
(A)
Atrium
(A)
LeftRight
Ventricle (V)
Systemic
capillaries
Systemic circuit Systemic circuit Systemic circuit
Systemic
capillaries
Incomplete
septum
Incomplete
septum
Left
systemic
aorta
LeftRight
Right
systemic
aorta
A A
V V
Lung
capillaries
Lung
capillaries
Pulmonary circuit
A A
V V
LeftRight
Systemic
capillaries
Key
Oxygen-rich blood
Oxygen-poor blood
Mammals and Birds

Concept 42.2: Coordinated cycles of heart
contraction drive double circulation in
mammals
• The mammalian cardiovascular system meets the
body’s continuous demand for O2

Mammalian Circulation
• Blood begins its flow with the right ventricle
pumping blood to the lungs
• In the lungs, the blood loads O2 and unloads CO2
• Oxygen-rich blood from the lungs enters the heart
at the left atrium and is pumped through the aorta
to the body tissues by the left ventricle
• The aorta provides blood to the heart through the
coronary arteries

• Blood returns to the heart through the superior
vena cava (blood from head, neck, and forelimbs)
and inferior vena cava (blood from trunk and hind
limbs)
• The superior vena cava and inferior vena cava
flow into the right atrium
Animation: Path of Blood Flow in Mammals

Animation: Path of Blood Flow in Mammals
Right-click slide / select “Play”

Superior vena cava
Pulmonary
artery
Capillaries
of right lung
Pulmonary
vein
Aorta
Inferior
vena cava
Right ventricle
Capillaries of
abdominal organs
and hind limbs
Right atrium
Aorta
Left ventricle
Left atrium
Pulmonary vein
Pulmonary
artery
Capillaries
of left lung
Capillaries of
head and forelimbs
Figure 42.6

The Mammalian Heart: A Closer Look
• A closer look at the mammalian heart provides a
better understanding of double circulation

Figure 42.7
Pulmonary artery
Right
atrium
Semilunar
valve
Atrioventricular
valve
Right
ventricle
Left
ventricle
Atrioventricular
valve
Semilunar
valve
Left
atrium
Pulmonary
artery
Aorta

• The heart contracts and relaxes in a rhythmic
cycle called the cardiac cycle
• The contraction, or pumping, phase is called
systole
• The relaxation, or filling, phase is called diastole

Figure 42.8-1
Atrial and
ventricular diastole
0.4
sec
1

Figure 42.8-2
Atrial and
Atrial systole and ventricular
diastole
0.1
sec
0.4
sec
2
1

Figure 42.8-3
Atrial and
Atrial systole and ventricular
diastole
Ventricular systole and atrial
diastole
0.1
sec
0.4
sec
0.3 sec
2
1
3

• The heart rate, also called the pulse, is the
number of beats per minute
• The stroke volume is the amount of blood
pumped in a single contraction
• The cardiac output is the volume of blood
pumped into the systemic circulation per minute
and depends on both the heart rate and stroke
volume

• Four valves prevent backflow of blood in the heart
• The atrioventricular (AV) valves separate each
atrium and ventricle
• The semilunar valves control blood flow to the
aorta and the pulmonary artery

• The “lub-dup” sound of a heart beat is caused by
the recoil of blood against the AV valves (lub) then
against the semilunar (dup) valves
• Backflow of blood through a defective valve
causes a heart murmur

Maintaining the Heart’s Rhythmic Beat
• Some cardiac muscle cells are self-excitable,
meaning they contract without any signal from the
nervous system
• The sinoatrial (SA) node, or pacemaker, sets the
rate and timing at which cardiac muscle cells
contract
• Impulses that travel during the cardiac cycle can
be recorded as an electrocardiogram (ECG or
EKG)

Figure 42.9-1
SA node
(pacemaker)
ECG
1

Figure 42.9-2
SA node
(pacemaker)
AV
node
ECG
1 2

Figure 42.9-3
SA node
(pacemaker)
AV
node Bundle
branches Heart
apex
ECG
1 2 3

Figure 42.9-4
SA node
(pacemaker)
AV
node Bundle
branches Heart
apex
Purkinje
fibers
ECG
1 2 3 4

• Impulses from the SA node travel to the
atrioventricular (AV) node
• At the AV node, the impulses are delayed and
then travel to the Purkinje fibers that make the
ventricles contract

• The pacemaker is regulated by two portions of the
nervous system: the sympathetic and
parasympathetic divisions
• The sympathetic division speeds up the
pacemaker
• The parasympathetic division slows down the
pacemaker
• The pacemaker is also regulated by hormones
and temperature

Concept 42.3: Patterns of blood pressure and
flow reflect the structure and arrangement
of blood vessels
• The physical principles that govern
movement of water in plumbing systems also
influence the functioning of animal circulatory
systems

Blood Vessel Structure and Function
• A vessel’s cavity is called the central lumen
• The epithelial layer that lines blood vessels is
called the endothelium
• The endothelium is smooth and minimizes
resistance

Figure 42.10
Artery
Red blood cells
Endothelium
Artery
Smooth
muscle
Connective
tissue
Capillary
Valve
Vein
Vein
Basal lamina
Endothelium
Smooth
muscle
Connective
tissue
100 µm
LM
Venule
15µm
LM
Arteriole
Red blood cell
Capillary

Figure 42.10a
Endothelium
Artery
Smooth
muscle
Connective
tissue
Capillary
Valve
Vein
Basal lamina
Endothelium
Smooth
muscle
Connective
tissue
VenuleArteriole

Figure 42.10b
Artery
Red blood cells
Vein
100 µm
LM

Figure 42.10c
15µm
LM
Red blood cell
Capillary

• Capillaries have thin walls, the endothelium plus
its basal lamina, to facilitate the exchange of
materials
• Arteries and veins have an endothelium, smooth
muscle, and connective tissue
• Arteries have thicker walls than veins to
accommodate the high pressure of blood pumped
from the heart
• In the thinner-walled veins, blood flows back to the
heart mainly as a result of muscle action

Blood Flow Velocity
• Physical laws governing movement of fluids
through pipes affect blood flow and blood pressure
• Velocity of blood flow is slowest in the capillary
beds, as a result of the high resistance and large
total cross-sectional area
• Blood flow in capillaries is necessarily slow for
exchange of materials

Figure 42.11
Aorta
ArteriesArterioles
C
apillaries
Venules
Veins
Venae
cavae
Systolic
pressure
Diastolic
pressure
0
20
40
60
80
100
120
0
10
20
30
40
50
Pressure
(mmHg)
Velocity
(cm/sec)Area(cm2
)
0
1,000
2,000
3,000
4,000
5,000

Blood Pressure
• Blood flows from areas of higher pressure to areas
of lower pressure
• Blood pressure is the pressure that blood exerts
against the wall of a vessel
• In rigid vessels blood pressure is maintained; less
rigid vessels deform and blood pressure is lost

Changes in Blood Pressure During the
Cardiac Cycle
• Systolic pressure is the pressure in the arteries
during ventricular systole; it is the highest pressure
in the arteries
• Diastolic pressure is the pressure in the arteries
during diastole; it is lower than systolic pressure
• A pulse is the rhythmic bulging of artery walls with
each heartbeat

Regulation of Blood Pressure
• Blood pressure is determined by cardiac output
and peripheral resistance due to constriction of
arterioles
• Vasoconstriction is the contraction of smooth
muscle in arteriole walls; it increases blood
pressure
• Vasodilation is the relaxation of smooth muscles
in the arterioles; it causes blood pressure to fall

• Vasoconstriction and vasodilation help maintain
adequate blood flow as the body’s demands
change
• Nitric oxide is a major inducer of vasodilation
• The peptide endothelin is an important inducer of
vasoconstriction

Blood Pressure and Gravity
• Blood pressure is generally measured for an artery
in the arm at the same height as the heart
• Blood pressure for a healthy 20 year old at rest is
120 mm Hg at systole and 70 mm Hg at diastole

Blood pressure reading: 120/70
120
70
Sounds
stop
Sounds
audible in
stethoscope
120
Artery
closed
1 2 3
Figure 42.12

• Fainting is caused by inadequate blood flow to the
head
• Animals with longer necks require a higher systolic
pressure to pump blood a greater distance against
gravity
• Blood is moved through veins by smooth muscle
contraction, skeletal muscle contraction, and
expansion of the vena cava with inhalation
• One-way valves in veins prevent backflow of blood

Direction of blood flow
in vein (toward heart) Valve (open)
Skeletal muscle
Valve (closed)
Figure 42.13

Capillary Function
• Blood flows through only 5−10% of the body’s
capillaries at a time
• Capillaries in major organs are usually filled to
capacity
• Blood supply varies in many other sites

• Two mechanisms regulate distribution of blood in
capillary beds
– Contraction of the smooth muscle layer in the wall
of an arteriole constricts the vessel
– Precapillary sphincters control flow of blood
between arterioles and venules
• Blood flow is regulated by nerve impulses,
hormones, and other chemicals

Figure 42.14
Precapillary
sphincters
Thoroughfare
channel
Arteriole
Capillaries
Venule
(a) Sphincters relaxed
Arteriole Venule
(b) Sphincters contracted

• The exchange of substances between the blood
and interstitial fluid takes place across the thin
endothelial walls of the capillaries
• The difference between blood pressure and
osmotic pressure drives fluids out of capillaries at
the arteriole end and into capillaries at the venule
end
• Most blood proteins and all blood cells are too
large to pass through the endothelium

Figure 42.15
INTERSTITIAL
FLUID Net fluid movement out
Blood
pressure
Osmotic
pressure
Arterial end
of capillary Direction of blood flow
Venous end
of capillary
Body cell

Fluid Return by the Lymphatic System
• The lymphatic system returns fluid that leaks out
from the capillary beds
• Fluid, called lymph, reenters the circulation
directly at the venous end of the capillary bed and
indirectly through the lymphatic system
• The lymphatic system drains into veins in the neck
• Valves in lymph vessels prevent the backflow of
fluid

• Lymph nodes are organs that filter lymph and
play an important role in the body’s defense
• Edema is swelling caused by disruptions in the
flow of lymph

Concept 42.4: Blood components contribute
to exchange, transport, and defense
• With open circulation, the fluid that is pumped
comes into direct contact with all cells
• The closed circulatory systems of vertebrates
contain blood, a specialized connective tissue

Blood Composition and Function
• Blood consists of several kinds of cells suspended
in a liquid matrix called plasma
• The cellular elements occupy about 45% of the
volume of blood

Figure 42.17
Plasma 55%
Constituent Major functions
Water
Ions (blood
electrolytes)
Sodium
Potassium
Calcium
Magnesium
Chloride
Bicarbonate
Solvent for
carrying other
substances
Osmotic balance,
pH buffering,
and regulation
of membrane
permeablity
Plasma proteins
Osmotic balance,
pH buffering
Albumin
Fibrinogen
Immunoglobulins
(antibodies)
Clotting
Defense
Substances transported by blood
Nutrients
Waste products
Respiratory gases
Hormones
Separated
blood
elements
Basophils
Neutrophils Monocytes
Lymphocytes
Eosinophils
Platelets
Erythrocytes (red blood cells) 5–6 million
250,000–400,000 Blood
clotting
Transport
of O2 and
some CO2
Defense and
immunity
FunctionsNumber per µL
(mm3
) of blood
Cell type
Cellular elements 45%
Leukocytes (white blood cells) 5,000–10,000

Plasma 55%
Constituent Major functions
Water
Ions (blood
electrolytes)
Sodium
Potassium
Calcium
Magnesium
Chloride
Bicarbonate
Solvent for
carrying other
substances
Osmotic balance,
pH buffering,
and regulation
of membrane
permeablity
Plasma proteins
Osmotic balance, pH bufferingAlbumin
Fibrinogen
Immunoglobulins (antibodies)
Clotting
Defense
Substances transported by blood
Nutrients
Waste products
Separated
blood
elements
Respiratory gases
Hormones
Figure 42.17a

Separated
blood
elements
Basophils
Neutrophils
Monocytes
Lymphocytes
Eosinophils
Platelets
Erythrocytes (red blood cells) 5–6 million
250,000–400,000 Blood
clotting
Transport
of O2 and
some CO2
Defense and
immunity
FunctionsNumber per µL
(mm3
) of blood
Cell type
Cellular elements 45%
Leukocytes (white blood cells) 5,000–10,000
Figure 42.17b

Plasma
• Blood plasma is about 90% water
• Among its solutes are inorganic salts in the form of
dissolved ions, sometimes called electrolytes
• Another important class of solutes is the plasma
proteins, which influence blood pH, osmotic
pressure, and viscosity
• Various plasma proteins function in lipid transport,
immunity, and blood clotting

Cellular Elements
• Suspended in blood plasma are two types of cells
– Red blood cells (erythrocytes) transport oxygen O2
– White blood cells (leukocytes) function in defense
• Platelets, a third cellular element, are fragments of
cells that are involved in clotting

• Red blood cells, or erythrocytes, are by far the
most numerous blood cells
• They contain hemoglobin, the iron-containing
protein that transports O2
• Each molecule of hemoglobin binds up to four
molecules of O2
• In mammals, mature erythrocytes lack nuclei and
mitochondria
Erythrocytes

• Sickle-cell disease is caused by abnormal
hemoglobin proteins that form aggregates
• The aggregates can deform an erythrocyte into a
sickle shape
• Sickled cells can rupture, or block blood vessels

Leukocytes
• There are five major types of white blood cells, or
leukocytes: monocytes, neutrophils, basophils,
eosinophils, and lymphocytes
• They function in defense by phagocytizing bacteria
and debris or by producing antibodies
• They are found both in and outside of the
circulatory system

Platelets
• Platelets are fragments of cells and function in
blood clotting

Blood Clotting
• Coagulation is the formation of a solid clot from
liquid blood
• A cascade of complex reactions converts inactive
fibrinogen to fibrin, forming a clot
• A blood clot formed within a blood vessel is called
a thrombus and can block blood flow

Figure 42.18
Collagen fibers
1 2 3
Platelet
Platelet
plug
Fibrin
clot
Fibrin clot formation
Red blood cell 5 µm
Clotting factors from:
Platelets
Damaged cells
Plasma (factors include calcium, vitamin K)
Enzymatic cascade
Prothrombin Thrombin
Fibrinogen Fibrin
+

Collagen fibers
1
Platelet
Platelet
plug
Fibrin
clot
Clotting factors from:
Platelets
Damaged cells
Plasma (factors include calcium, vitamin K)
Enzymatic cascade
Prothrombin Thrombin
Fibrinogen Fibrin
+
Fibrin clot
formation
2 3
Figure 42.18a

Figure 42.18b
Fibrin
clot Red blood cell 5 µm

Stem Cells and the Replacement of Cellular
Elements
• The cellular elements of blood wear out and are
being replaced constantly
• Erythrocytes, leukocytes, and platelets all develop
from a common source of stem cells in the red
marrow of bones, especially ribs, vertebrae,
sternum, and pelvis
• The hormone erythropoietin (EPO) stimulates
erythrocyte production when O2 delivery is low

Stem cells
(in bone marrow)
Myeloid
stem cells
Lymphoid
stem cells
B cells T cells
Lymphocytes
Erythrocytes
Neutrophils
Basophils
EosinophilsPlatelets
Monocytes
Figure 42.19

Cardiovascular Disease
• Cardiovascular diseases are disorders of the heart
and the blood vessels
• Cardiovascular diseases account for more than
half the deaths in the United States
• Cholesterol, a steroid, helps maintain membrane
fluidity

• Low-density lipoprotein (LDL) delivers
cholesterol to cells for membrane production
• High-density lipoprotein (HDL) scavenges
cholesterol for return to the liver
• Risk for heart disease increases with a high LDL
to HDL ratio
• Inflammation is also a factor in cardiovascular
disease

Atherosclerosis, Heart Attacks, and Stroke
• One type of cardiovascular disease,
atherosclerosis, is caused by the buildup of
plaque deposits within arteries

Lumen of artery
Smooth
muscle
Endothelium
Plaque
Smooth
muscle
cell
T lymphocyte
Extra-
cellular
matrix
Foam cell
Macrophage
Plaque rupture
LDL
CholesterolFibrous cap
1 2
43
Figure 42.20

• A heart attack, or myocardial infarction, is the
death of cardiac muscle tissue resulting from
blockage of one or more coronary arteries
• Coronary arteries supply oxygen-rich blood to the
heart muscle
• A stroke is the death of nervous tissue in the
brain, usually resulting from rupture or blockage of
arteries in the head
• Angina pectoris is caused by partial blockage of
the coronary arteries and results in chest pains

Risk Factors and Treatment of
Cardiovascular Disease
• A high LDL to HDL ratio increases the risk of
cardiovascular disease
• The proportion of LDL relative to HDL can be
decreased by exercise, not smoking, and avoiding
foods with trans fats
• Drugs called statins reduce LDL levels and risk of
heart attacks

Figure 42.21
Individuals with two functional copies of
PCSK9 gene (control group)
Plasma LDL cholesterol (mg/dL)
Individuals with an inactivating mutation in
one copy of PCSK9 gene
Plasma LDL cholesterol (mg/dL)
Average = 63 mg/dLAverage = 105 mg/dL
30
20
10
0
0 50 100 150 200 250 300 0
0
10
20
30
50 100 150 200 250 300
Percentofindividuals
RESULTS
Percentofindividuals

• Inflammation plays a role in atherosclerosis and
thrombus formation
• Aspirin inhibits inflammation and reduces the risk
of heart attacks and stroke
• Hypertension, or high blood pressure, promotes
atherosclerosis and increases the risk of heart
attack and stroke
• Hypertension can be reduced by dietary changes,
exercise, and/or medication

Concept 42.5: Gas exchange occurs across
specialized respiratory surfaces
• Gas exchange supplies O2 for cellular respiration
and disposes of CO2

Partial Pressure Gradients in Gas Exchange
• A gas diffuses from a region of higher partial
pressure to a region of lower partial pressure
• Partial pressure is the pressure exerted by a
particular gas in a mixture of gases
• Gases diffuse down pressure gradients in the
lungs and other organs as a result of differences in
partial pressure

Respiratory Media
• Animals can use air or water as a source of O2, or
respiratory medium
• In a given volume, there is less O2 available in
water than in air
• Obtaining O2 from water requires greater efficiency
than air breathing

Respiratory Surfaces
• Animals require large, moist respiratory surfaces
for exchange of gases between their cells and the
respiratory medium, either air or water
• Gas exchange across respiratory surfaces takes
place by diffusion
• Respiratory surfaces vary by animal and can
include the outer surface, skin, gills, tracheae, and
lungs

Gills in Aquatic Animals
• Gills are outfoldings of the body that create a large
surface area for gas exchange

Figure 42.22
Parapodium
(functions as gill)
(a) Marine worm (b) Crayfish
Gills
Gills
Tube foot
(c) Sea star
Coelom

Figure 42.22a
Parapodium (functions as gill)
(a) Marine worm

Figure 42.22b
(b) Crayfish
Gills

Figure 42.22c
Gills
Tube foot
(c) Sea star
Coelom

• Ventilation moves the respiratory medium over
the respiratory surface
• Aquatic animals move through water or move
water over their gills for ventilation
• Fish gills use a countercurrent exchange
system, where blood flows in the opposite
direction to water passing over the gills; blood is
always less saturated with O2 than the water it
meets

Figure 42.23
Gill
arch
O2-poor blood
O2-rich blood
Blood
vessels
Gill arch
Operculum
Water
flow
Water flow
Blood flow
Countercurrent exchange
PO (mm Hg) in water
2
150
PO (mm Hg)
in blood
2
120 90 60 30
140 110 80 50 20
Net diffu-
sion of O2
Lamella
Gill filaments

Gill
arch
Operculum
Water
flow
Blood
vessels
Gill arch
Gill filaments
Figure 42.23a

O2-poor blood
Water flow
Blood flow
Countercurrent exchange
PO (mm Hg) in water
2
150
PO (mm Hg)
in blood
2
140
Net diffu-
sion of O2
Lamella
O2-rich blood
120 90 60 30
110 80 50 20
Figure 42.23b

Tracheal Systems in Insects
• The tracheal system of insects consists of tiny
branching tubes that penetrate the body
• The tracheal tubes supply O2 directly to body cells
• The respiratory and circulatory systems are
separate
• Larger insects must ventilate their tracheal system
to meet O2 demands

Tracheoles Mitochondria Muscle fiber
2.5µm
Tracheae
Air sacs
External opening
Trachea
Air
sac Tracheole
Body
cell
Air
Figure 42.24

Figure 42.24a
Tracheoles Mitochondria Muscle fiber
2.5µm

Lungs
• Lungs are an infolding of the body surface
• The circulatory system (open or closed) transports
gases between the lungs and the rest of the body
• The size and complexity of lungs correlate with an
animal’s metabolic rate

Mammalian Respiratory Systems: A Closer
Look
• A system of branching ducts conveys air to the
lungs
• Air inhaled through the nostrils is warmed,
humidified, and sampled for odors
• The pharynx directs air to the lungs and food to
the stomach
• Swallowing tips the epiglottis over the glottis in the
pharynx to prevent food from entering the trachea

Figure 42.25
Pharynx
Larynx
(Esophagus)
Trachea
Right lung
Bronchus
Bronchiole
Diaphragm
(Heart)
Capillaries
Left
lung
Dense capillary bed
enveloping alveoli (SEM)
50 µm
Alveoli
Branch of
pulmonary artery
(oxygen-poor
blood)
Branch of
pulmonary vein
(oxygen-rich
blood)
Terminal
bronchiole
Nasal
cavity

Pharynx
Larynx
(Esophagus)
Trachea
Right lung
Bronchus
Bronchiole
Diaphragm
(Heart)
Left
lung
Nasal
cavity
Figure 42.25a

Capillaries
Alveoli
Branch of
pulmonary artery
(oxygen-poor
blood)
Branch of
pulmonary vein
(oxygen-rich
blood)
Terminal
bronchiole
Figure 42.25b

Figure 42.25c
Dense capillary bed
enveloping alveoli (SEM)
50 µm

• Air passes through the pharynx, larynx, trachea,
bronchi, and bronchioles to the alveoli, where
gas exchange occurs
• Exhaled air passes over the vocal cords in the
larynx to create sounds
• Cilia and mucus line the epithelium of the air ducts
and move particles up to the pharynx
• This “mucus escalator” cleans the respiratory
system and allows particles to be swallowed into
the esophagus

• Gas exchange takes place in alveoli, air sacs at
the tips of bronchioles
• Oxygen diffuses through the moist film of the
epithelium and into capillaries
• Carbon dioxide diffuses from the capillaries across
the epithelium and into the air space

• Alveoli lack cilia and are susceptible to
contamination
• Secretions called surfactants coat the surface of
the alveoli
• Preterm babies lack surfactant and are vulnerable
to respiratory distress syndrome; treatment is
provided by artificial surfactants

RDS deaths Deaths from other causesRESULTS
40
30
20
10
0
0 800 1,600 2,400 3,200 4,000
Body mass of infant (g)
Surfacetension(dynes/cm)
Figure 42.26

Concept 42.6: Breathing ventilates the lungs
• The process that ventilates the lungs is breathing,
the alternate inhalation and exhalation of air

How an Amphibian Breathes
• An amphibian such as a frog ventilates its lungs by
positive pressure breathing, which forces air
down the trachea

How a Bird Breathes
• Birds have eight or nine air sacs that function as
bellows that keep air flowing through the lungs
• Air passes through the lungs in one direction only
• Every exhalation completely renews the air in the
lungs

Anterior
air sacs
Posterior
air sacs
Lungs
1 mm
Airflow
Air tubes
(parabronchi)
in lung
Anterior
air sacs
Lungs
Second inhalationFirst inhalation
Posterior
air sacs 3
2
4
1
4
31
2 Second exhalationFirst exhalation
Figure 42.27

Figure 42.27a
1 mm
Airflow
Air tubes
(parabronchi)
in lung

How a Mammal Breathes
• Mammals ventilate their lungs by negative
pressure breathing, which pulls air into the lungs
• Lung volume increases as the rib muscles and
diaphragm contract
• The tidal volume is the volume of air inhaled with
each breath

Figure 42.28
Rib cage
expands.
Air
inhaled.
Air
exhaled.
Rib cage gets
smaller.
1 2
Lung
Diaphragm

• The maximum tidal volume is the vital capacity
• After exhalation, a residual volume of air remains
in the lungs

Control of Breathing in Humans
• In humans, the main breathing control centers
are in two regions of the brain, the medulla
oblongata and the pons
• The medulla regulates the rate and depth of
breathing in response to pH changes in the
cerebrospinal fluid
• The medulla adjusts breathing rate and depth to
match metabolic demands
• The pons regulates the tempo

• Sensors in the aorta and carotid arteries monitor
O2 and CO2 concentrations in the blood
• These sensors exert secondary control over
breathing

Homeostasis:
Blood pH of about 7.4
CO2 level
decreases. Stimulus:
Rising level of
CO2 in tissues
lowers blood pH.
Response:
Rib muscles
and diaphragm
increase rate
and depth of
ventilation.
Carotid
arteries
AortaSensor/control center:
Cerebrospinal fluid
Medulla
oblongata
Figure 42.29

Concept 42.7: Adaptations for gas exchange
include pigments that bind and transport
gases
• The metabolic demands of many organisms
require that the blood transport large quantities of
O2 and CO2

Coordination of Circulation and Gas
Exchange
• Blood arriving in the lungs has a low partial
pressure of O2 and a high partial pressure of CO2
relative to air in the alveoli
• In the alveoli, O2 diffuses into the blood and CO2
diffuses into the air
• In tissue capillaries, partial pressure gradients
favor diffusion of O2 into the interstitial fluids and
CO2 into the blood

Exhaled air Inhaled air
Pulmonary
arteries
Systemic
veins
Systemic
arteries
Pulmonary
veins
Alveolar
capillaries
Alveolar
spacesAlveolar
epithelial
cells
Inhaled
air
160
120
80
40
0Heart
8 1
2
3
46
7
CO2 O2
Systemic
capillariesCO2 O2
Body tissue5
a) The path of respiratory gases in the circulatory
system
(b) Partial pressure of O2 and CO2 at different points in the
circulatory system numbered in (a)
4321 5 6 7
Exhaled
air
Partialpressure(mmHg)
PO2
PCO 2
8
Figure 42.30

Figure 42.30a
Exhaled air Inhaled air
Pulmonary
arteries
Systemic
veins
Systemic
arteries
Pulmonary
veins
Alveolar
capillaries
Alveolar
spacesAlveolar
epithelial
cells
Heart
Systemic
capillariesCO2 O2
Body tissue
(a) The path of respiratory gases in the circulatory
system
CO2 O2
8 1
2
37
6 4
5

Inhaled
air
160
(b) Partial pressure of O2 and CO2 at different points in the
circulatory system numbered in (a)
1
Exhaled
air
Partialpressure(mmHg) PO2
120
80
40
0
2 3 4 5 6 7 8
PCO 2
Figure 42.30b

Respiratory Pigments
• Respiratory pigments, proteins that transport
oxygen, greatly increase the amount of oxygen
that blood can carry
• Arthropods and many molluscs have hemocyanin
with copper as the oxygen-binding component
• Most vertebrates and some invertebrates use
hemoglobin
• In vertebrates, hemoglobin is contained within
erythrocytes

Hemoglobin
• A single hemoglobin molecule can carry four
molecules of O2, one molecule for each iron
containing heme group
• The hemoglobin dissociation curve shows that a
small change in the partial pressure of oxygen can
result in a large change in delivery of O2
• CO2 produced during cellular respiration lowers
blood pH and decreases the affinity of hemoglobin
for O2; this is called the Bohr shift

Figure 42.UN01
Iron
Heme
Hemoglobin

Figure 42.31
2
(a) PO and hemoglobin dissociation at pH 7.4
Tissues during
exercise
Tissues
at rest
Lungs
PO (mm Hg)
2
(b) pH and hemoglobin dissociation
PO (mm Hg)
2
0 20 40 60 80 100
0
20
40
60
80
100
0 20 40 60 80 100
0
20
40
60
80
100
Hemoglobin
retains less
O2 at lower pH
(higher CO2
concentration)
pH 7.2
pH 7.4
O2 unloaded
to tissues
during exercise
O2saturationofhemoglobin(%)
O2 unloaded
to tissues
at rest

Figure 42.31a
2
(a) PO and hemoglobin dissociation at pH 7.4
Tissues during
exercise
Tissues
at rest
Lungs
PO (mm Hg)
2
0 20 40 60 80 100
0
20
40
60
80
100
O2 unloaded
to tissues
during exercise
O2 unloaded
to tissues
at rest

(b) pH and hemoglobin dissociation
PO (mm Hg)
2
0 20 40 60 80 100
0
20
40
60
80
100
Hemoglobin
retains less
O2 at lower pH
(higher CO2
concentration)
pH 7.2
pH 7.4
Figure 42.31b

Carbon Dioxide Transport
• Hemoglobin also helps transport CO2 and assists
in buffering the blood
• CO2 from respiring cells diffuses into the blood and
is transported either in blood plasma, bound to
hemoglobin, or as bicarbonate ions (HCO3
–
)
Animation: O2 from Lungs to Blood
Animation: CO2 from Blood to Lungs
Animation: CO2 from Tissues to Blood
Animation: O2 from Blood to Tissues

Animation: O2 from Blood to Tissues

Animation: CO2 from Tissues to Blood

Animation: CO2 from Blood to Lungs

Animation: O2 from Lungs to Blood

Figure 42.32 Body tissue
Capillary
wall
Interstitial
fluid
Plasma
within capillary
CO2 transport
from tissuesCO2 produced
CO2
CO2
CO2
H2O
H2CO3 Hb
Red
blood
cell Carbonic
acid
Hemoglobin (Hb)
picks up
CO2 and H+
.
H+
HCO3
−
Bicarbonate
+
HCO3
−
HCO3
−
To lungs
CO2 transport
to lungs
HCO3
−
H2CO3
H2O
CO2
H++
Hb
Hemoglobin
releases
CO2 and H+
.
CO2
CO2
CO2
Alveolar space in lung

Figure 42.32a
Body tissue
Capillary
wall
Interstitial
fluid
Plasma
within capillary
CO2 transport
from tissuesCO2 produced
CO2
H2O
H2CO3 Hb
Red
blood
cell Carbonic
acid
Hemoglobin (Hb)
picks up
CO2 and H+
.
H+HCO3
−
Bicarbonate
+
HCO3
−
To lungs
CO2
CO2

Figure 42.32b
HCO3
− CO2 transport
to lungs
H2CO3
H2O
H++
Hb
Hemoglobin
releases
CO2 and H+
.
CO2
Alveolar space in lung
To lungs
HCO3
−
CO2
CO2
CO2

Respiratory Adaptations of Diving Mammals
• Diving mammals have evolutionary adaptations
that allow them to perform extraordinary feats
– For example, Weddell seals in Antarctica can
remain underwater for 20 minutes to an hour
– For example, elephant seals can dive to 1,500 m
and remain underwater for 2 hours
• These animals have a high blood to body volume
ratio

• Deep-diving air breathers stockpile O2 and deplete
it slowly
• Diving mammals can store oxygen in their
muscles in myoglobin proteins
• Diving mammals also conserve oxygen by
– Changing their buoyancy to glide passively
– Decreasing blood supply to muscles
– Deriving ATP in muscles from fermentation once
oxygen is depleted

Figure 42.UN02
Exhaled air
Alveolar
epithelial
cells
Pulmonary
arteries
Systemic
veins
Heart
CO2 O2
Body tissue
Systemic
capillaries
Systemic
arteries
Pulmonary
veins
Alveolar
capillaries
Alveolar
spaces
Inhaled air
CO2 O2

Figure 42.UN03
Fetus
Mother
PO (mm Hg)
2
0 20 40 60 80 100
100
80
60
40
20
0
O2saturationof
hemoglobin(%)

Biology "B" / Ch42

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