Drug to treat skin cancer in the offing

1. Drug to treat skin cancer in
the offing
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2. Contd…
Scientists have discovered a new drug that shows promise for treating deadly
forms of skin cancer, such as melanoma, which are resistant to existing
therapies.The new compound, named SBI-756, targets a specific molecular
machine known as the translation initiation complex. These structures are in
every cell and play the critical role of translating messenger RNA (mRNA) into
proteins.
In cancer cells the complex is impaired, producing extra protein and
providing a growth advantage to tumours.SBI-756 causes the translation
complex to dissociate, and inhibit melanoma cell growth.
About 50% of melanomas are caused by mutations in a specific gene called
BRAF. Patients are commonly prescribed vemurafenib, a BRAF inhibitor that
shrinks tumours. The team found that if SBI-756 is co-administered with
vemurafenib, the tumours disappeared and did not reoccur.
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