International Breast Cancer Conference

1. 11th
MEET THE PROFESSOR
Advanced International
Breast Cancer Course
PADUA, SEPTEMBER 10th
-11th
-12th
, 2015
Directors
Pier Franco Conte, Gabriel N. Hortobagyi
SECTION OF ONCOLOGY

2. Breast cancer represents the front runner in cancer research in many aspects.
First, this is a common, chronic and lethal disease where medical interventions
are successfully inducing a continuous decline in mortality in spite of increasing
incidence. Second, biology drives the entire diagnostic-therapeutic work up of
these patients. This is why, nowadays, a breast multidisciplinary team should also
include pathologists, molecular biologists, oncogeneticists besides the “classic”
clinical specialties. Third, many highly effective interventions are available for each
step of the diagnostic and therapeutic work-up of these patients. The increased
complexity of the disease, the availability of multiple effective choices and the
high expectations of our patients are raising the bar of clinical excellence in this
field.
With this goal in mind, the Programme of this international Conference includes
lectures on molecular characterization, updated treatments of early and advanced
disease, management of difficult cases and hereditary syndromes.
Clinical case discussions and debates are planned to allow a continuous and
fruitful exchange of experiences and opinions between speakers and participants.
This 11th
Breast Cancer Conference includes a highly qualified international
faculty, but will maintain its characteristics of a friendly forum where international
opinion leaders and attendees will exchange experiences and share the most
exiting advances.
In order to reward scientific excellence and to foster international cooperation,
the International Scientific Committee of the 11th
AIBCC will award the 5th
International Prize for Breast Cancer Research to a scientist who has published a
breakthrough paper in the previous year.
We welcome medical oncologists, pathologists, breast surgeons, radiation
oncologists and basic scientists to listen to breast cancer leaders and to exchange
experiences in a friendly atmosphere.
Presentation
Gynaecologists and obstretrics, medical oncologists, pathologists, radiation
oncologists, radiologists, surgeons; biologists and nurses.
Addressed to

3. Thursday, September 10th
8.00 Registration
8.45 Introduction to the Conference
Pier Franco Conte, Gabriel N. Hortobagyi
SESSION I – LIFE STYLE AND BREAST CANCER
Chairmen: Gabriel N. Hortobagyi, Manuel Zorzi
9.00 Prevention of breast cancer with life style changes and drugs
Alessandra Gennari
9.20 Life style after breast cancer diagnosis
Giovanna Masala
9.40 Fertility and breast cancer
Fedro Peccatori
10.00 Q&A
10.30 Coffee break
SESSION II – GENETIC TESTING
Chairmen: Alberto Amadori, Sibylle Loibl
11.00 BRCA: from genetic to predictive test
Andrew Tutt
11.30 BRCA: germline versus somatic mutations
Claude Houdayer
12.00 In and around the BRCA genes: the clinical relevance of variants
of unknown significance and genetic modifiers
Marco Montagna
12.30 Multiplex germline mutation assays: ready for clinical use?
Gabriel N. Hortobagyi
13.00 QA
13.15 Lunch
SESSION III – PATHOLOGY AND GENOMICS
Chairman: Gabriel N. Hortobagyi
14.15 “Liquid biopsy”: CTCs, ctDNA, microRNA – Ready for prime time?
François Clement Bidard
Programme

4. 14.45 Clinical validity versus clinical utility of genomic tests
Aleix Prat
15.15 Discordant pathology and genomic data: what should drive the
therapeutic choice?
Giuseppe Viale
15.45 QA
16.00 Coffee break
CUP syndrome– Clinical Case Discussion I
Chairmen: Fernando Bozza, Pier Franco Conte
16.30 CUP cases will be presented and the audience will be asked to
vote on different options
Presenter of the cases: Maria Vittoria Dieci
17.10 A panel composed by pathologists, radiologists, surgeons and medical
oncologists will discuss the votes of the audience and express their
opinions (Hesham Ahmed Gaballah Elghazaly, Carlos A. Garcia-
Etienne, Gabriel N. Hortobagyi, Sibylle Loibl, Luigi Pescarini, Philip
Poortmans, Corrado Tinterri)
18.00 Adjourn
Friday, September 11th
Imaging – Clinical Case Discussion II
Chairmen: Pier Franco Conte, Luigi Pescarini
8.30 Problematic/difficult cases of breast imaging will be presented. The
presenters will ask the audience to express their opinion (voting system)
Presenters of the cases: Alessandro Coran
8.50 A panel composed by radiologists, surgeons and clinicians will express
their opinions and comment on the audience voting (Riccardo Audisio,
Hesham Ahmed Gaballah Elghazaly, Carlos A. Garcia- Etienne, Gabriel
N. Hortobagyi, Luigi Pescarini, Philip Poortmans, Corrado Tinterri)

5. Axillary Staging– Clinical Case Discussion III
Chairmen: Pier Franco Conte, Massimo Rugge
9.30 Cases of early breast cancer patients will be presented: extensive DCIS
without infiltrating carcinoma, DCIS with multiple micro-filtrating foci,
infiltrating carcinoma with micrometastatic SN, infiltrating carcinoma
with different biologies with macrometastatic SN. The audience will be
asked to vote on different options
Presenter of the cases: Tania Saibene
9.50 A panel composed by pathologists, surgeons, medical and radiation
oncologists will discuss the votes of the audience and express their
opinion (Riccardo Audisio, Pier Franco Conte, Hesham Ahmed Gaballah
Elghazaly, Carlos A.Garcia-Etienne Gabriel N. Hortobagyi, Sybille Loibl,
Enrico Orvieto, Philip Poortmans, Corrado Tinterri, Giuseppe Viale)
10.30 Coffee break
SESSION IV – SURGERY RADIOTHERAPY
Chairmen: Sibylle Loibl, Donato Nitti
11.00 Oncoplastic surgery: opportunities and challenges
Riccardo Audisio
11.30 Risk reducing surgery: role in BRCAmut and BRCAwt patients
Corrado Tinterri
12.00 Update on radiation therapy (hypofractionation, boost, IORT,
postmastectomy radiotherapy)
Philip Poortmans
12.30 QA
12.45 Lunch
SESSION V – PREMENOPAUSAL EARLY BREAST CANCER
Chairman: Gabriel N. Hortobagyi
13.45 Management of very young patients
Sibylle Loibl
14.15 Adjuvant endocrine therapy after SOFT and TEXT trials
Marco Colleoni
14.45 Management of endocrine and sexual problems in young patients
Giovanbattista Nardelli, Salvatore Gizzo

6. 15.15 Pregnancy after breast cancer
Lucia Del Mastro
15.45 QA
17.30 Ceremony for the presentation of the University of Padua Award for
Advances in Breast Cancer 2015
18.00 Lecture of the Awardee
18.30 Cocktail
The Ceremony and the cocktail will take place in palazzo Bo,
Via VIII Febbraio 2, Padua
Saturday, September 12th
SESSION VI – NEW THERAPEUTIC ALGORITHMS FOR ABC PATIENTS
Chairmen: Pier Franco Conte, Gabriel N. Hortobagyi
9.00 HR+ ABC
Stephen Johnston
9.30 HER2+ ABC
Valentina Guarneri
10.00 Triple negative advanced breast cancer
Miguel Martin
11.00 Coffee break
11.30 Immunity and triple negative breast cancer
Peter Schmid
12.00 Immunity and HER2+ BC
Gianpaolo Bianchini
12.30 New promising check-point immunomodulators in solid tumors
Filippo De Braud
13.00 From development to access: how to harmonise sustainability,
equanimity and innovation
Jonas Bergh
13.30 QA
14.30 Adjourn and final evaluation questionnaire

7. Pier Franco Conte
Division of Medical Oncology 2
Istituto Oncologico Veneto IRCCS
Department of Surgery, Oncology
and Gastroenterology
University of Padua (I)
Gabriel N. Hortobagyi
Department of Breast Medical Oncology
University of Texas
MD Anderson Cancer Center
Houston (USA)
Directors
Scientific Committee
Jonas Bergh
Department of Oncology-Pathology
Karolinska Institute and University Hospital
Stockholm (SW)
Hesham Ahmed Gaballah Elghazaly
Department of Clinical Oncology
and nuclear medicine
University of Ainshams
Cairo (EG)
Valentina Guarneri
Division of Medical Oncology 2
Istituto Oncologico Veneto IRCCS
Department of Surgery, Oncology
and Gastroenterology
University of Padua (I)
Jacek Jassem
Department of Oncology and Radiotherapy
Medical University of Gdansk (PL)
Stephen Johnston
NIHR Biomedical Research Centre for Cancer
Royal Marsden NHS Foundation Trust
Institute of Cancer Research
London (UK)
Sibylle Loibl
German Breast Group
Department of Medicine and Research
University of Frankfurt (D)
Miguel Martin
Medical Oncology Service
Hospital Universitario Gregorio Marañon
Madrid (S)
Donato Nitti
Department of Surgery, Oncology
and Gastroenterology
University of Padua (I)
Philip Poortmans
President of ESTRO
Department of Radiation Oncology
Radbound University Medical Centre
Nijmegen (NL)

8. Alberto Amadori
Division of Oncological Molecular Diagnostic
and Immunology
Istituto Oncologico Veneto IRCCS
Department of Surgery, Oncology
and Gastroenterology
University of Padua (I)
Riccardo Audisio
Department of Surgery
St Helens Teaching Hospital
Liverpool (UK)
Jonas Bergh
Department of Oncology-Pathology
Karolinska Institute and University Hospital
Stockholm (SW)
Giampaolo Bianchini
Department of Medical Oncology
San Raffaele Hospital
Milan (I)
François-Clement Bidard
Cancer Foundation
Curie Institute
Paris (F)
Fernando Bozza
Division of Breast Surgery
Istituto Oncologico Veneto IRCCS
Padua (I)
Marco Colleoni
Division of Medical Senology
European Institut of Oncology (IEO)
Milan (I)
Pier Franco Conte
Division of Medical Oncology 2
Istituto Oncologico Veneto IRCCS
Department of Surgery, Oncology and
Gastroenterology
University of Padua (I)
Alessandro Coran
Breast Imaging Unit
Istituto Oncologico Veneto IRCCS
Padua (I)
Filippo De Braud
Department of Clinical Oncology
National Cancer Institute
Milan (I)
Lucia Del Mastro
Medical Oncology A- Innovative therapies
development
National Institute for Cancer Research
Genoa (I)
Maria Vittoria Dieci
Division of Medical Oncology 2
Istituto Oncologico Veneto IRCCS
Department of Surgery, Oncology and
Gastroenterology
University of Padua (I)
Hesham Ahmed Gaballah Elghazaly
University of Ainshams
Department of Clinical Oncology and Nuclear
Medicine
Il Cairo (E)
Carlos A. Garcia-Etienne
Division of Breast Surgery
S. Matteo Hospital
Pavia (I)
Alessandra Gennari
Department of Medical Oncology
Galliera Hospital
Genova (I)
Salvatore Gizzo
Department of Gynecology and Obstetrics
University Hospital
Padua (I)
Valentina Guarneri
Division of Medical Oncology 2
Istituto Oncologico Veneto IRCCS
Department of Surgery, Oncology and
Gastroenterology
University of Padua (I)
Gabriel N. Hortobagyi
Department of Breast Medical Oncology
The University of Texas - MD Anderson Cancer
Center
Houston (USA)
Speakers

9. Claude Houdayer
Department de Biologie des Tumeurs - Service
Genetique
Institut Curie
Paris (F)
Stephen Johnston
NIHR Biomedical Research Centre for Cancer
Royal Marsden NHS Foundation Trust
Institute of Cancer Research
London (UK)
Sibylle Loibl
German Breast Group
Department of Medicine and Research
University of Frankfurt (D)
Miguel Martin
Medical Oncology Service
Hospital Universitario Gregorio Marañon
Madrid (S)
Giovanna Masala
Molecular and Nutritional Epidemiology Unit
Cancer Research and Prevention Institute-ISPO
Florence (I)
Marco Montagna
Hereditary Tumors Group Breast and Ovary
Cancer
Department of Oncological Molecular
Diagnostic and Immunology
Istituto Oncologico Veneto IRCCS
University of Padua (I)
Giovanni Battista Nardelli
Department of Gynecology and Obstetrics
University Hospital
Padova (I)
Enrico Orvieto
General Pathology Cytopathology Unit
Department of Medicine-DIMED University of
Padua (I)
Fedro Peccatori
Department of Medical Oncology
European Institute of Oncology
Milan (I)
Luigi Pescarini
Department of Radiology
Diagnostic Breast Unit
Istituto Oncologico Veneto IRCCS
University of Padua (I)
Philip Poortmans
President of ESTRO
Department of Radiation Oncology
Radbound University Medical Centre
Nijmegen (NL)
Aleix Prat
Institute of Oncology (VHIO)
Vall d’Hebron
Barcellona (E)
Massimo Rugge
General Pathology Cytopathology Unit
Department of Medicine-DIMED
University of Padua (I)
Tania Saibene
Division of Breast Surgery
Istituto Oncologico Veneto IRCCS
Padua (I)
Peter Schmid
Centre for Experimental Cancer Medicine
Bart Cancer Institute
Queen Mary University
London (UK)
Corrado Tinterri
Depatment of Senology
Humanitas Clinical Institute
Rozzano (I)
Andrew Tutt
Breast Cancer Research Unit
Kings College
London (UK)
Giuseppe Viale
Department of Pathology
European Institute of Oncology
University of Milan (I)
Manuel Zorzi
Cancer Registry of Veneto
Padova (I)

10. Awards
UNIVERSITY OF PADUA AWARD FOR ADVANCES IN BREAST CANCER 2015
The Scientific Committee will select young researchers ( 40 years from any
country) who have published in an international peer-reviewed journal, as
the principal author, a manuscript reporting important clinical or biological
advances in breast cancer. Prof. Conte and Prof. Hortobagyi will select the
final winner which will be invited to present his/her study during the annual
Conference
Under 35
Free admission is available for 3 persons “Under 35”. Registration forms
will be accepted on a first-come, first-served basis until spaces are filled.
The Organization Secretariat will confirm the registration by email.
Un’azione sostenibile a favore della formazione
Iscrizione gratuita per i medici UNDER 35 fino a esaurimento posti

11. CME
Based on the in force Italian regulations, Accademia Nazionale di Medicina
(provider n. 31) will assign to the activity CME (31-130969): 9,5 CME points.
The Meeting is addressed to physicians specialized in: gynaecology and
obstretrics, oncology, pathology, radiodiagnostics, radiotherapy, general
surgery; biologists and nurses.
It will not be possible to give credits to physicians specialized in different fields.
The credit certification is subject to:
• attendance at the entire Meeting
• the completion of the meeting evaluation form
• the completion of the final questionnaire (at least 75% of correct answers)
We would like to remind to participants that only 1/3 of CME credits acquired
during the years 2014/2016 can come frome a sponsorship.
ESMO-Mora Credits
ESMO-Mora accreditation to be provided.
Official Language
The official language of the Meeting is English. No simultaneous translation will
be provided.

12. Registration
The registration fee is € 250,00 tax free.
It includes the conference bag, the conference book and all coffee breaks and
lunches. It does not include Hotel accomodation, dinners and travel expenses.
Under the article 54 T.U.I.R and within the limits set out therein, the costs of
participation in this activity are deductible in determining self-employment
income.
To register, please send:
• registration form duly filled out (even when sponsored by a Pharmaceutical Company
• privacy statement and consent to the use of personal data (as in the back of the form)
• payment
to Accademia Nazionale di Medicina – Palazzina CUP II Piano, Via Massarenti 9,
40138 Bologna (fax 0039 051 6364605 – e.mail: info.bologna@accmed.org,
within August 24th
, 2015.
Registration quote can be paid by: non-transferable cheque addressed to Accademia
Nazionale di Medicina; bank transfer addressed to: ACCADEMIA NAZIONALE DI
MEDICINA, Banca Prossima Spa - IBAN code: IT 35 Q0335901600100000121744
- SWIFT code: BCITITMX (indicate: “Registration of Dr. ... at Course 15_RE_ 1257);
Credit Card Details Mastercard. Visa, Eurocard (NO AMEX cards).
Online registration is possible on the website http://meettheprofessor.accmed.org
By submitting the form and the payment, your registration is completed with
the exception of specific decisions of the Meeting Secretariat.
Incomplete registration will NOT be admitted.
The registration will be confirmed by e-mail, please put your e-mail address on
the registration form.
CANCELLATION
• if the participants minimum number is not reached, Accademia Nazionale
di Medicina will advise by a written communication and proceed with the
total refund of the fee.
• In order to cancel please give advise with a written communication to
Accademia Nazionale di Medicina within 10 days from the beginning. A
70% of the registration fee will be returned. Any cancellation after that
deadline will not be reimbursed.

13. Meeting Venue
Centro Congressi Padova A. Luciani
Via Forcellini 170/A
Padova
Tel. +39 049/8033711
How to reach the meeting venue:
By Car:
The Highway exits are
Padova Est, 5 Km from the Meeting Venue
Padova Zona Industriale, 6 Km from the Meeting Venue
By Train:
Padova is in the Center of Veneto, it is easy to reach with the trains Milano-
Venezia and Bologna-Venezia. The Meeting Venue is 4 Km from the train
station
By Plane
Venezia Airport - Marco-Polo: 43 km (about 40 minutes by car)
Treviso Airport- Canova: 63 km (about 50 minutes by car)

14. With the patronage of
INSTITUTIONS
SCIENTIFIC SOCIETIES
Comune di Padova

15. With the unconditional contribution of
CONTRIBUTORS
› AMGEN
› BAYER
› EISAI
› PHARMA MAR
› PIERRE FABRE PHARMA
› SANDOZ
BRONZE SPONSOR
GOLD SPONSOR
SILVER SPONSOR

16. Sponsored by
ACCADEMIA NAZIONALE DI MEDICINA
www.accmed.org
General Manager: Stefania Ledda
Organizing Partner
Forum Service
Via Martin Piaggio 17/6
16122 Genova
Information:
http://meettheprofessor.accmed.org
Ph. +39 051 2144898-6360080
Fax +39 051 6364605
info.bologna@accmed.org
Hotel booking
booking@forumservice.net
Ph. +39 010 83794244