Latest Advances in Clinical Senology and Oncology

1. Senology Newsletter Page 1 of 3
Senology.org - Newsletter
International Senologic and Oncologic Scientific Community
"Connecting specialists worldwide"
Editor-in-chief: Gian Paolo Andreoletti, MD
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Literature Selection
Mohr SB et al.: "Serum 25-hydroxyvitamin d and prevention of breast cancer: pooled analysis",
Anticancer Res. 2011 Sep;31(9):2939-48
Dong JY et al.: "Dietary fiber intake and risk of breast cancer: a meta-analysis of prospective cohort
studies", Am J Clin Nutr. 2011 Sep;94(3):900-5
Bosco JL et al.: "Regular aspirin use and breast cancer risk in US Black Women", Cancer Causes
Control. 2011 Aug 30. [Epub ahead of print]
Hardman WE et al.: "Dietary Walnut Suppressed Mammary Gland Tumorigenesis in the C(3)1 TAg
Mouse", Nutr Cancer. 2011 Aug-Sep;63(6):960-70
Cybulski C et al.: "Risk of Breast Cancer in Women With a CHEK2 Mutation With and Without a Family
History of Breast Cancer", J Clin Oncol. 2011 Aug 29. [Epub ahead of print]
Niikura N et al.: "FDG-PET/CT Compared with Conventional Imaging in the Detection of Distant
Metastases of Primary Breast Cancer", Oncologist. 2011;16(8):1111-9
Kiess AP et al.: "Adjuvant trastuzumab reduces locoregional recurrence in women who receive
breast-conservation therapy for lymph node-negative, human epidermal growth factor receptor 2-
positive breast cancer", Cancer. 2011 Sep 1. doi: 10.1002/cncr.26484. [Epub ahead of print]
Chen JH et al.: "Breast Cancer: Evaluation of Response to Neoadjuvant Chemotherapy with 3.0-T MR
Imaging", Radiology. 2011 Aug 30. [Epub ahead of print]
Howard-McNatt M et al.: "Contralateral prophylactic mastectomy in breast cancer patients who test
negative for BRCA mutations", Am J Surg. 2011 Sep;202(3):298-302
Bagaria SP et al.: "Prognostic Value of Basal Phenotype in HER2-overexpressing Breast Cancer", Ann
Surg Oncol. 2011 Aug 31. [Epub ahead of print]
http://www.senology.org/newsletter/Newsl_Sep2011.htm 09/09/2011

2. Senology Newsletter Page 2 of 3
Discussion
Christiansen P et al.: "Mortality Rates Among Early-Stage Hormone Receptor-Positive Breast Cancer
Patients: A Population-Based Cohort Study in Denmark", J Natl Cancer Inst. 2011 Aug 31. [Epub
ahead of print]
"Is adjuvant endocrine therapy necessary for older breast cancer patients with
hormone-responsive early-stage tumors?" - Share your opinion on LinkedIn®.
Comment
"Benefit of single-injection Depot Progesterone before surgery in node positive breast cancer
patients" - Raj Badwe, Tata Memorial Hospital, Mumbai, India
"This is the first randomized evidence suggesting benefit of short-term peri-operative hormone therapy
(progesterone) in DFS and OS in node positive breast cancer. The results not only suggest an easily
implementable cost-effective intervention in routine clinical practice but also offers some biological insights
about when does metastases set in? and how modulation of events at the time of surgery affects a chronic
disease? In absence of side effects and low cost of intervention this would be the most effective intervention
for the developing world as well as cash strapped health care systems globally. The results need to be
reproduced in other parts of the world"
(Comment on: Badwe R et al.: "Single-Injection Depot Progesterone Before Surgery and Survival in
Women With Operable Breast Cancer: A Randomized Controlled Trial", J Clin Oncol. 2011 Jul 20;29
(21):2845-51)
Fragments of History
Richard Volkmann, "Beitrage zur Chirurgie", Leipzig, Germany (1875): “I make it a rule never to do a partial
amputation for cancer of the breast, but remove the entire breast even for the smallest tumors, and at the
same time I take away a liberal piece of skin. The skin defect is, of course, very great when one operates in
this manner, and the wound, in consequence, requires a long time for healing. Furthermore, in making the
lower incision I cut right down to the pectoralis muscle and clean its fibres, as I would for a class-room
dissection, carrying the knife parallel with the muscular fasciculi and penetrating into their interstices. The
fascia of the muscle is,accordingly, entirely removed. I was led to adopt this procedure because, on
microscopical examination, I repeatedly found when I had not expected it that the fascia was already
carcinomatous,whereas the muscle was certainly not involved. (…). It seems to me, therefore, that the fascia
serves for a time as a barrier, and is able to bring to a halt the spreading growth of the carcinoma"
Calendar of Events
Breast Cancer Symposium 2011, September 8-10, 2011, San Francisco, California
7th Meet the Professor. Modena International Breast Cancer Conference (MIBCC)
October 5-7, 2011, Modena, Italy - under the Patronage of Senology.org
1st Advanced Breast Cancer International Consensus Conference, November 3-5, 2011, Lisbon,
Portugal
33rd Congress of the French Senologic Society November 9-11, 2011 Marseille France
AORTIC (African Organisation for Research and Training in Cancer) - 8th International Conference,
November 28 - December 2, 2011, Cairo, Egypt
Literature Selection
Takahashi Y et al.: "Fibrous stroma is associated with poorer prognosis in lung squamous cell
carcinoma patients", J Thorac Oncol. 2011 Sep;6(9):1460-7
Gibson TM et al.: "Pre- and postfortification intake of folate and risk of colorectal cancer in a large
prospective cohort study in the United States", Am J Clin Nutr. 2011 Sep, ajcn. 002659
Ma Y et al.: "Association Between Vitamin D and Risk of Colorectal Cancer: A Systematic Review of
Prospective Studies", J Clin Oncol. 2011 Aug 29. [Epub ahead of print]
Aune D et al.: "Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review
and non-linear dose-response meta-analysis of prospective studies", Ann Oncol. 2011 Sep 2. [Epub
ahead of print]
Tang JY et al.: "Menopausal Hormone Therapy and Risks of Melanoma and Nonmelanoma Skin
Cancers: Women's Health Initiative Randomized Trials", J Natl Cancer Inst. 2011 Aug 30. [Epub ahead
http://www.senology.org/newsletter/Newsl_Sep2011.htm 09/09/2011

3. Senology Newsletter Page 3 of 3
of print]
Darefsky AS et al.: "Adult glioblastoma multiforme survival in the temozolomide era: A population-
based analysis of surveillance, epidemiology, and end results registries", Cancer. 2011 Aug 31. doi:
10.1002/cncr.26494. [Epub ahead of print]
Literature Selection
Coriddi M et al.: "Reduction mammaplasty, obesity, and massive weight loss: temporal relationships
of satisfaction with breast contour", Plast Reconstr Surg. 2011 Sep;128(3):643-50
Makinen N et al.: "MED12, the Mediator Complex Subunit 12 Gene, Is Mutated at High Frequency in
Uterine Leiomyomas", Science. 2011 Aug 25. [Epub ahead of print]
Senology.org opened an on line community (Senology.org - International Senologic and Oncologic Scientific
Community) within the Doctorsbook.com platform, which will allow you to remain in touch and communicate with
colleagues. Join us and receive the weekly oncological Doctorsbook Newsletter!
Stay informed....
Recent Advances in Clinical Medicine
Sankaran VG et al.: "A functional element necessary for fetal hemoglobin silencing", N Engl J Med.
2011 Sep 1;365(9):807-14
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http://www.senology.org/newsletter/Newsl_Sep2011.htm 09/09/2011