Medicinal Chemistry : Sympathomimetic Agents : Adrenomimetic agents

1. : SYMPHATHOMIMETIC AGENT
19/6/2018 By-Cadet.Rajkumar Kumawat

2. Sympathomimetic agent
9/6/2018 2By-Cadet.Rajkumar Kumawat

3. • Sympathomimetic drugs are stimulants
compound which mimic the effect of endogenous
agonist of the sympathetic nervous system.
• Drug can make the action partially or completely
or it may also be defined as the substance which
sympathetic system is known as
sympathomimetic agent or sympathomimetic
drugs
Sympathomimetic agent
9/6/2018 3By-Cadet.Rajkumar Kumawat

4. Classification of sympathomimetic
agent
1. Direct acting
2. Indirect acting
3. Mixed acting
9/6/2018 4By-Cadet.Rajkumar Kumawat

5.  Nor-epinephrine
 Epinephrine
 Phenylephrine
 Dopamine
 Methyldopa
 Salbutamol
Hydroxyamphetamine
Pseudoephedrine
Propylhexedrine
Ephedrine
MetaAraminol
Direct acting Mixed actingIndirect acting
9/6/2018 5By-Cadet.Rajkumar Kumawat

6. Direct acting sympathomimetic
agent
• They act through complexation with specific
receptors they are represented by nor-
adrenaline for the activation of beta receptor
phenolic hydroxy function in meta at the
catechol nucleus and at the side chain
Hydroxide in beta and Amine especially the
phenolic hydroxyl seems to be relatively more
critical for activation of beta receptors.
9/6/2018 6By-Cadet.Rajkumar Kumawat

7. Nor-epinephrine
• Chemical formula: C8H11NO3
• Mol. Mass : 169.18 g/mol
Uses:
Norepinephrine is similar to adrenaline. It works by
constricting (narrowing) theblood vessels and
increasing blood pressure and blood glucose (sugar)
levels.9/6/2018 7By-Cadet.Rajkumar Kumawat

8. Epinephrine
• Chemical formula: C9H13NO3
• Mol. Mass : 183.204 g/mol
Uses :
This medication is used in emergencies to treat very
serious allergic reactions to insect stings/bites, foods,
drugs, or other substances. Epinephrine acts quickly to
improve breathing, stimulate the heart, raise a dropping
blood pressure, reverse hives, and reduce swelling of the
face, lips, and throat.9/6/2018 8By-Cadet.Rajkumar Kumawat

9. Salbutamol
• Chemical formula: C13H21NO3
• Mol. Mass : 239.311 g/mol
Uses :
This drug relaxes the smooth muscle in the lungs and
opens airways to improve breathing. It is used to treat
asthma, chronic bronchitis, emphysema and to
prevent exercise-related asthma.9/6/2018 9By-Cadet.Rajkumar Kumawat

10. Dopamine
• Chemical formula: C8H11NO2
• Mol. Mass : 153.18 g/mol
Uses :
It works by improving the pumping strength of the heart and
improves blood flow to the kidneys. Dopamine is used to treat
certain conditions that occur when you are in shock, which
may be caused by heart attack, trauma, surgery, heart
failure, kidney failure, and other serious medical conditions.
9/6/2018 10By-Cadet.Rajkumar Kumawat

11. Methyldopa
• Chemical formula: C10H13NO4
• Mol. Mass : 211.215 g/mol
Uses :
This medication is used alone or with other medications to
treat high blood pressure (hypertension). Lowering high blood
pressure helps prevent strokes, heart attacks, and kidney
problems. Methyldopa works byrelaxing blood vessels so
blood can flow more easily.
9/6/2018 11By-Cadet.Rajkumar Kumawat

12. Indirect acting
9/6/2018 12By-Cadet.Rajkumar Kumawat

13. Hydroxyamphetamine
• Chemical formula: C9H13NO
• Mol. Mass : 151.206 g/mol
Uses :
Hydroxyamphetamine/tropicamide is a
sympathomimetic and anticholinergic combination eye
drop. It works by relaxing the muscles of the eye to
cause the pupil to dilate or widen (mydriasis).9/6/2018 13By-Cadet.Rajkumar Kumawat

14. Pseudoephedrine
• Chemical formula: C10H15NO
• Mol. Mass : 165.23 g/mol
Uses :
Pseudoephedrine is a decongestant that shrinks blood vessels
in the nasal passages. Dilated blood vessels can cause nasal
congestion (stuffy nose). Pseudoephedrine is used to treat
nasal and sinus congestion, or congestion of the tubes that
drain fluid from your inner ears,9/6/2018 14By-Cadet.Rajkumar Kumawat

15. Propylhexedrine
• Chemical formula: C10H21N
• Mol. Mass : 155.29 g/mol
Uses :
It is an analogue of methamphetamine that is used
medicinally for relief of congestion due to colds,
allergies and allergic rhinitis and recreationally for its
euphoric effects.
9/6/2018 15By-Cadet.Rajkumar Kumawat

16. Mixed Action…
9/6/2018 16By-Cadet.Rajkumar Kumawat

17. Ephedrine
• Chemical formula: C10H15NO
• Mol. Mass : 165.24 g/mol
Uses :
Ephedrine is a central nervous system stimulant used to treat
breathing problems (as a bronchodilator), nasal congestion (as
a decongestant), low blood pressureproblems
(orthostatic hypotension), or myasthenia gravis.
9/6/2018 17By-Cadet.Rajkumar Kumawat

18. Metaraminol
• Chemical formula: C9H13NO3
• Mol. Mass : 167.205 g/mol
Uses :
It is a potent sympathomimetic amine used in the
prevention and treatment of hypotension, particularly
as a complication of anesthesia.
9/6/2018 18By-Cadet.Rajkumar Kumawat

19. 9/6/2018 19By-Cadet.Rajkumar Kumawat