sauth delhi call girls in Bhajanpura 🔝 9953056974 🔝 escort Service
Adrenocortical carcinoma
1. Dr. Ravi Roshan Khadka
Phase B resident
Department of Urology
BSMMU
2. Patient Profile
Name: Md .Sakhawat
Age : 28 years
Gender: Male
Occupation: day labor in Malaysia
Marital status : unmarried
Fathers name : Md Mujim sheikh
Permanent add: Dhaka
Date of admission : 02/09/15
3. Chief complaints
1) Pain at left upper abdomen------1 year
2) Loss of appetite and nausea ---- 1 year
3) Occasional fever --------- 1 year
4. History of present illness
According to patient’s statement he was apparently
well 1 year back and then he gradually developed pain
at left upper abdomen which was dull aching in nature
& mild to moderate in intensity. Pain radiates to back
which used to aggravated by exertion and food intake
and relieved by medication. Pain was episodic in
nature and associated with nausea and loss of appetite
and weight loss of 21 kg in 1 year. He also complaints
of occasional low grade fever which was relived by
antipyretic.
5. History of present illness
He gave no history of coughing out of blood, blood
mixed urine, passage of stone in urine, cloudy urine or
bone pain.
With these complaints he visited general physician
and treated symptomatically and 1½ months back after
returning to bangladesh he underwent thorough
investigations and later referred to department of
urology for further evaluation and management.
6. Past medical and surgical history
Nothing contributory
Family history
• Nothing contributory
7. Personal history
Education level : SSC
Occupation: day labor in Malaysia
Smoking/ Tobacco: non smoker
Alcohol : non alcoholic
Socioeconomic status : lower middle class
9. General physical examinations
Appearance: anxious and illooking
Built: average
Weight: 54 kg height: 1.65 m BMI=19.8
Anaemia: moderately pallor
Jaundice: Absent
Oedema: Absent
Lymph nodes: Accessible lymph nodes are not palpable
Clubbing : Absent
Koilonychia : Absent
Cyanosis : absent
10. Abdomen Examination
Inspection:
Scaphoid shape with slight bulge at left hypochondriac
region
Umbilicus centrally placed and inverted
Flanks are not full
No visible peristalsis and engorged vein
No visible cough impulse
11. Abdomen Examination
Palpation
Temperature ; not raised
Mass at left hypochondriac region
There is a Hard, mild tender, irregular mass at left
hypochondriac , epigastric and lumbar region measuring
about 8 cm from left costal margin along MCL.
Margins are irregular and upper limit of margin couldn’t be
traced.
Insinuation is not possible and notch is absent.
Mass moves with respiration.
Ballotable
Head rising test; Mass didn’t bulge
Knee elbow test ; Mass doesn’t fall forward
No other organomegaly
12. Abdomen Examination
Percussion
Dull with band of resonance
Tympanytic all over abdomen
Auscultation
No bruit
Bowel sound ; present
D/R/E ; Normal
Genital exam : normal
14. Salient feature
Md. Sakhawat 28 years old , non diabetic,
normotensive, nonsmoker, male , hailing from dhaka
presented with gradual onset of episodic dull aching
left hypochondriac pain for 1 year. Pain was mild to
moderate in intensity that radiates to back and
aggravates by exertion and food intake and relieved by
medication. He also complaints of nausea , vomiting
and significant weight loss (21 kg in 1 year) for same
duration. He is also experiencing occasional low grade
fever.
15. Salient feature
He gave no h/o hemoptysis, hemturia, graveluria,
pyuria or bone pain. With these complaints he visited
general physician and treated symptomatically and 1 ½
months back after returning to Bangladesh he
underwent thorough investigations and later referred
to department of urology for further evaluation and
management.
16. Salient feature
On physical examination, vitals are stable, moderately
pallor, All accessible lymph nods are not palpable.
Jaundice and koilonychia are absent.
Abdominal examination revealed; Hard, mild tender,
irregular mass at left hypochondriac ,epigastric and
lumbar region measuring about 8 cm from left costal
margin along MCL. Margins of mass are irregular
whose upper limit couldn’t be traced and notch is not
felt. Insinuation is not possible. Mass moves with
respiration and its ballotable .
It is dull on percussion with band of resonance and
bruit is absent.
17. Salient feature
No other organomegaly, ascites is absent and hernial
orifices are intact.
Genitalia, CVS, Respiratory and CNS reveled no
abnormalities
38. Position
Under G/A patient kept
in supine position with
bridge beneath left
flank and painting and
draping done.
Incision
modified chevron /
hockey stick (extended
left sub costal).
Intervening layers are
incised along the line of
incision
39. Abdomen cavity
reached and findings
noted
Large ,hard irregular
mass seen subcostally
which was pushing
pancreas and spleen
upward.
Mass was adherent to
transverse mesocolon
and diaphragm
Multiple dilated vessels
were seen over mass.
Operability assessed.
40. • Dissection was
started laterally by
dissecting
posterior
peritoneum along
left colon and
carried out
proximally.
• Adherent transverse
mesocolon was
clamped, cut and
ligated to free it
from mass and
hence colon was
reflected medially.
41. • Dilated vessels over mass
were clamped, cut and
ligated which made the
mass slightly free.
• Blunt and sharp dissection
carried out along the lower
border of mass as there was
still confusion regarding
origin.
• As the upper pole of kidney
was reached ,a plane was
found between mass and
kidney hence dissection
was continued but after a
while plane obliterated
hence Nephrectomy was
planned, thinking of mass
arising from upper pole of
kidney
43. Superiorly a plane was
found between panaceas
and the mass and hence
dissection carried out
along the plane .
44. Medial dissection
Renal hilum was approached and dissection was carried out
to identify renal vessels separately.
First renal artery and then renal vein were clamped, cut and
ligated separately by 1/0 silk.
Ureter was identified , clamped, cut and ligated.
45. While dissecting
medially ,another
large vessel found
reaching kidney
which was clamped,
cut and ligated (main
renal artery).
Finally blunt
dissection carried
laterally and
posteriorly to remove
specimen
46. After removing specimen,hot mop was placed and then
observed for any bleeding.
After ensuring haemostatis 16 fr drain kept in situ
Abdomen was closed in layer by 1/0 vicryl and skin closed
by stapler
47.
48.
49.
50. Follow up ----1st POD
Subjective
Pain abdomen and one episode of fever at evening (101 F)
Objective
BP: 100/70 mmHg , pulse: 84/min
T: 98.4deg F , R/R = 16/min
Lung; B/L expansion normal, Vesicular breath sound and no
added sound,
Heart : NAD
P/A : Mild tenderness, soft, Bowel sound absent and dressing
dry.
Drain : 270 ml ,reddish
Urine Output : 2800ml, clear
Plan: I/V fluids and antibiotics, analgesic, Chest physio and
limb exercise.
51. Follow up ----2nd POD
Subjective
Pain abdomen and one episode of fever at evening (100.4 F)
Objective
BP: 110/70 mmHg , pulse: 80/min
T: 98.6deg F , R/R = 16/min
Lung; B/L expansion normal, Vesicular breath sound and no
added sound,
Heart : NAD
P/A : Mild tenderness, soft, Bowel sound- absent and
dressing dry.
Drain : 40-50 ml ,blackish
Urine Output : 1900ml, clear
Plan: I/V fluids and antibiotics, analgesic ensured, Chest
physio and limb exercise.
52. Follow up ----3rd POD
Subjective
Pain abdomen an one episode of fever at evening (100.6 F)
Objective
BP: 100/60 mmHg , pulse: 86/min
T: 98.2deg F , R/R = 14/min
Lung; B/L expansion normal, Vesicular breath sound and no
added sound,
Heart : NAD
P/A : Mild tenderness, soft, Bowel sound- present and
dressing dry.
Drain : 20 ml ,blackish
Urine Output : 1900ml, clear
Plan: sips of water, I/V fluids and antibiotics, analgesic
ensured, Chest physio and limb exercise,
53. Follow up
4th POD
Slight pain
BP: 100/60 mmHg, Pulse = 82/min,
Swelling and mild tenderness at cannula site
Heart= NAD
Lung =NAD
P/A = Soft, mild tender, BS + , Dressing dry
Drain : Nil
Plan:
Oral, catheter off, i/v cannula changed
CBC, S. Creatinine and CXR-P/A sent
62. Introduction and Epidemiology
Rare malignancy with an incidence of 0.5 to 2 per
million.
Bimodal age distribution that peaks in children in the
first decade of life and adults in the fourth to fifth
decdes of life.
Slight female predominance of 1.5 to 2.1
Majority of ACCs are sporadic and unilateral
loss of TP53 function and increased IGF expression
represent late events in the tumorigenesis of sporadic
ACC
63. Clinical Characteristics
Incidental detection.
Tumor-related symptoms
Local symptoms: abdominal fullness, back pain, nausea
and vomiting.
Systemic / metastatic futures: Anorexia, anaemia,
asthenia and weight loss and features of metastasis.
Hormone secreting ACC (50% to 79% of adult and 90%
of pediatric ACCs)
66. Imaging- CT scan/ MRI
Size
Relative indicator of malignancy, with
4% to 5% of tumors less than 4 cm, 10% of tumors larger than
4 cm, and 25% of tumors greater than 6cm.
Common radiographic characteristic of ACC on CT
imaging include
the presence of irregular borders,
irregular enhancement,
calcifications
Necrotic areas with cystic degeneration.
Evaluation of spread/mets
IVC, Adjacent organs, Liver ,lungs, Bones
67. Role of biopsy
For diagnosing adrenal cortical carcinomas,
percutaneous needle biopsy is generally not performed
prior to surgical excision
due to a clinically unacceptable risk of needle-tract
seeding (Fassnacht et al, 2004; Schteingart et al, 2005).
The primary indication for needle biopsy is
in cases of unresectable, locally advanced, or metastatic
disease, to confirm the diagnosis prior to systemic
medical therapy.
69. •Stage I and II tumors are confined to the adrenal gland and are
distinguished by a size cutoff of 5 cm.
•Stage III disease includes tumor extension into adjacent adipose tissue or
having regional lymph node involvement.
•Stage IV disease includes tumors invading adjacent organs and the
presence of distant metastatic disease.
70. Management
Unfortunately, the majority of patients with
adrenal cortical carcinomas present with advanced
disease those who do have localized disease are at a
high risk of local recurrence and metastatic
progression.
Treatment of ACC often includes multimodal therapy
directed by a team of surgeons, medical oncologists,
endocrinologists, and radiation oncologists.
Despite aggressive surgical resection, adrenal
carcinoma is associated with a high rate (60% to
80%) of recurrent disease
71. Surgery
Complete surgical excision is essential in the management of
adrenal cortical carcinomas
En bloc resection of surrounding organs involved with locally
advanced disease should be performed whenever possible.
Cases of venous tumor thrombus involving the IVC may require
vascular bypass techniques, IVC replacement, and/or IVC interruption.
In cases of metastatic adrenal carcinoma,
Cytoreductive removal of the primary tumor and debulking
metastatectomy should be considered if greater than 90% of the disease
burden can be removed.
Although debulking surgery may not improve survival, it may alleviate
tumor-related side effects and facilitate additional therapies .
Local or distant disease recurrences, following initial resection,
should be considered for surgical excision and have been associated
with improved survival in retrospective series.
72. RADIATION
Currently there is a limited role for radiation for
therapy in the treatment of primary adrenal cortical
carcinomas;
Radiation therapy remains the treatment of choice in
Management of bone and CNS metastasis
To decrease local recurrence rates following complete
tumor resection, (with reported local recurrence rates
of 14% and 79%, with and without adjuvant radiation
therapy, respectively )
Unfortunately, a significant improvement in disease-
free or overall survival was not observed.
73. MEDICAL THERAPY
Mitotane is most commonly used chemotherapeutic
agent in the treatment of adrenal cortical carcinoma.
Benefit in the adjuvant setting following surgical
resection and in patients with metastatic disease
A significant increase in recurrence-free survival and
overall survival was noted in patients receiving
mitotane compared with controls
74. Follow up
Follow-up should include CT examination of the chest,
abdomen, and pelvis every 3 months for the first 2
years.
In patients with evidence of functional tumors,
measurement of the initially elevated hormones
postoperatively may help to reveal early disease
recurrence despite negative radiographic studies.
After a disease-free interval of 2 years, surveillance
should continue, but the frequency of imaging may
decrease.
Short chevron, hockey stick, extended left subcostal inision.
Findings:
In cases of suspicion for venous tumor thrombus,
MRI can be an essential tool in detecting the presence of a
tumor clot and delineating its extent.
Approach
Smaller radiographically organ- confined disease can be approached laparoscopically, but should be performed with caution due to the risk of tumor spillage