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Acid base balance
1. “If one advances confidently in
the direction of his dreams, he
will meet with a success
unexpected in common hours
--Henry David Thoreau
"Shoot for the moon. Even if you miss
it, you will land among the stars….!"
- Les Brown
3. Strong and Weak Acids and Bases
A strong acid ..rapidly dissociates and releases
large amounts of H+ in solution….HCl
Weak acids ..less tendency to dissociate their
ions … is H2CO3
A strong base … reacts rapidly and strongly with
H+ and quickly removes these from a solution…
OH-
A typical weak base is HCO3-
Most of the acids and bases in the extracellular
fluid that involved in normal acid-base
regulation are weak acids and bases
4. Volatile acids:
Can leave solution and enter the atmosphere.
H2C03 (carbonic acid).
Pco2 is most important factor in pH of body tissues.
Pco2 is a measurement of tension or partial
pressure of carbon dioxide in the blood.
The normal arterial pCO2 is 4.1- 5.6 k Pa (31- 42
mmHg)
5. Fixed Acids:
Acids that do not leave solution.
Sulfuric and phosphoric acids.(H2SO4&H3PO4)
Catabolism of amino acids, nucleic acids, and
phospholipids.
6. Organic Acids:
Byproducts of aerobic metabolism, during anaerobic
metabolism and during starvation, diabetes.
LACTIC ACID, KETONES ,PYRUVIC ACID
7. Normal Hydrogen Ion Concentration and pH of Body
Fluids
the blood H+ concentration is normally maintained
within tight limits around a normal value of about
0.00004 mEq/L (40 nEq/L)
Ph= log 1/H= -log [H]
Ph=7.4
13. There are three primary systems that
regulate the H+ concentration
(1) the chemical acid-base buffer systems of
the body fluids
(2) the respiratory center
(3) the kidneys
14. a buffer system is a combination of two
compounds that minimizes pH changes when
acid or base is added to a solution
A pair of substance is involved: one substance yield H+ ion
when PH is increased the other binds with H+ ion when pH
is decreased.
15. Chemical buffer system
Combination of weak acid and weak base
Binds to H+ as H+ concentration rises
Releases H+ as H+ concentration falls
Can restore normal pH almost immediately
Three major chemical buffer systems
Bicarbonate system
Phosphate system
Protein system
16. Accomplished by converting:
Strong acid Weak acid
Strong base Weak base
17. bicarbonate/carbonic acid
major plasma buffer
phosphate: H2PO4- / HPO42-
major urine buffer
ammonium: NH3 / NH4+
also used to buffer the urine
proteins: important in ICF
Hb: is the main buffer against CO2 changes
18. BICARBONATE BUFFER SYSTEM
Carbonic acid (H2CO3)
Weak acid
Bicarbonate ion (HCO3-)
Weak base
CO2 + H20 H2CO3 H+ + HCO3-
Works along with respiratory and urinary system
These systems remove CO2 or HCO3-
THE RATIO OF BICARBONATE TO CARBONIC ACID IS
NORMALLY 20:1
Alterations in the ratio alters Ph irrespective of
absolute concetrations
19. NaOH + H2CO3 H2O + Na HCO3
HCl + Na HCO3 NaCl + H2CO3
23. pK 6.1
the concentrations of CO2 and HCO3 not great.
the most powerful extracellular buffer in the body
the two elements of the buffer system are
regulated by the kidneys and the lungs
24. PHOSPHATE BUFFER SYSTEM
Dihydrogen phosphate ion (H2PO4-)
Weak acid
Monohydrogen phosphate ion (HPO42-)
Weak base
H2PO4- H+ + HPO42-
More important in buffering kidney filtrate than in
tissue
25. The main elements of the phosphate buffer
system are H2PO4- and HPO4
NaOH + NaH2PO4 H2O+ Na2HPO4
HCl + Na2HPO4 NaCl + NaH2PO4
26. pK 6.8
8 % of the concentration of the bicarbonate
buffer
the total buffering power less than that of the
bicarbonate buffering system.
27. the phosphate buffer is important in the tubular
fluids of the kidney for two reasons
(1) phosphate concentrated in the tubules
(2) the tubular fluid has lower pH than the
extracellular fluid does
- bringing the operating range of the buffer
closer to the pK (6.8) of the system
important in buffering intracellular fluid
because the concentration of phosphate in this
fluid is many times that in the extracellular
fluid
29. PROTEIN BUFFER SYSTEM
Proteins are more concentrated than bicarbonate
and phosphate buffers
Accounts for ~75% of all chemical buffering of body
fluids
Buffering ability due to certain functional groups of
amino acid residues
30. except for the red blood cells, the slowness
with which H+ and HCO3 move through the cell
membranes often delays the maximum ability of
the intracellular proteins to buffer extracellular
acid-base abnormalities.
the pKs of many of these protein systems close
to 7.4.
31. The buffer system buffers each other by shifting
hydrogen from buffer to other
32. Exhalation of carbon dioxide
Powerful, but only works with volatile acids
Doesn’t affect fixed acids like lactic acid
CO2 + H20 ↔ H2CO3 ↔ H+ + HCO3-
Body pH can be adjusted by changing rate
and depth of breathing
33. the overall buffering power of the respiratory
system is one to two times as great as the buffering
power of all other chemical buffers in the ECF
combined
47. compensatory mechanisms in respiratory acidosis
compensatory mechanisms in respiratory acidosis
*Image via Bing
48. Inadequate ventilation of anaesthetized
patient
When the effects of muscle relaxants have
not worn off or been fully reversed at the
end of anaesthesia
Risk increases when the patient has pre
existing pulmonary disease like ch. Bronchitis
or emphysema
Thoracic & upper abdominal incisions
49. A CONDITION WHERE THE ARTERIAL PCO2 IS
BELOW THE NORMAL RANGE
LESS THAN 31 MM OF HG
(OR) LESS THAN 5.6 KILO PASCALS
60. This is a calculated estimation of the
undetermined or unmeasured anions in the
blood
This is some times used to establish the
cause of metabolic acidosis
ANIONGAP= (Na) _ (HCO3+Cl)
NORMAL ANION GAP IS 10-16 mmol / L