The CARPHA Evidence Portal and MedCarib database work together to provide public health professionals in the Caribbean region access to evidence-based information. They do this by: 1) Indexing and cataloging relevant local data through the MedCarib methodology to support decision-making and policy development. 2) The CARPHA Evidence Portal is built on BIREME's Virtual Health Library platform and collects Caribbean evidence, while MedCarib provides a database of health and medicine information for the English-speaking Caribbean. 3) Strategies to realize this collaboration included bringing together experts, using BIREME's reliable ICT infrastructure, and sharing previously undiscovered information.