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What is Sentinella : A truly global opportunity A revolutionary & integrated equipment for : Real time intra-operative imaging of tumors and superficial OR deep lymph nodes , in open and/or laparoscopic surgery.  A peace of mind warranty  for surgeons and referring physicians!
Radioguided Surgery: Present Situation Fantastic results, BUT technological limitations: Long learning curve, technical limitation of probes; subjective assessment of sound, limitation of amplitude and depth of detection, low sensibility in nodes near by the tumor / small / deep.   Innovation is the vital spark of all human change v.s
Radioguided Surgery: Present Situation Limited depth of detection with conventional Gamma probes Problem ~2 or 3 cm
 
 
Dificulty of localization 3 6 Distance (cm)
Dificulty of localization 3 6 9 4x4 8x8 12x12 Distance (cm) FOV(cm)
Innovation is the vital spark of all human change Radioguided Surgery: wanted Situation NO technological limitations:  A complete system for radioguided surgery. Revolutionary integrated cancer detection equipment for ease use in / out the OR.   GAMMACAMERA + POINTERS + PROBE + VERIFICATION SOFTWARE Real time vision in OR of tumours and related drainage + lymph nodes, with high sensibility and sensitivity (>75% than probes 1 ): variable FOV and collimator, acquisition time, comparative images IN VIVO / EX VIVO + node verification software .   EVIDENCE BASED MEDICINE:  Wide range of international publications
What  can Sentinella improve?  Part 1 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],A B C Innovation is the vital spark of all human change accurate localisation  ex vivo verification: roll   technique – tumor margin
What  can Sentinella improve?  Part 2 ,[object Object],[object Object],[object Object],[object Object],[object Object],A B C Innovation is the vital spark of all human change
Sentinella specifications : A B C Innovation is the vital spark of all human change
Sentinella procedures : A B C Innovation is the vital spark of all human change
Practical example I: Sentinella in ROLL technique Images from H. Clinic Barcelona Dr. Sergi Vidal-Sicart (nm), Dra.P.Paredes (nm), Dr. G. Zanon (s) Innovation is the vital spark of all human change Centered lesion No Centered lesion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Practical example 2: Sentinella in H&N cancer  Images from NKI-AvL /  Dr. Renato Valdes Olmos Innovation is the vital spark of all human change ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Practical example 3: Sentinella in  Prostate cancer   Images from NKI-AvL /  Dr. Renato Valdes Olmos Innovation is the vital spark of all human change
Absence of perfusion: confirmation of death Normal encephallic blood  perfusion Confirmation of possible donors for transplants, encephalic death ,[object Object],[object Object],[object Object],[object Object],Practical example 4: Hospital Univ.Virgen Macarena Innovation is the vital spark of all human change Anterior Left Lateral  Anterior Left Lateral
Succesful experience in 4000 patients!

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R2Innovations / OncoVision : Sentinella - your new eyes

  • 1.  
  • 2. What is Sentinella : A truly global opportunity A revolutionary & integrated equipment for : Real time intra-operative imaging of tumors and superficial OR deep lymph nodes , in open and/or laparoscopic surgery. A peace of mind warranty for surgeons and referring physicians!
  • 3. Radioguided Surgery: Present Situation Fantastic results, BUT technological limitations: Long learning curve, technical limitation of probes; subjective assessment of sound, limitation of amplitude and depth of detection, low sensibility in nodes near by the tumor / small / deep. Innovation is the vital spark of all human change v.s
  • 4. Radioguided Surgery: Present Situation Limited depth of detection with conventional Gamma probes Problem ~2 or 3 cm
  • 5.  
  • 6.  
  • 7. Dificulty of localization 3 6 Distance (cm)
  • 8. Dificulty of localization 3 6 9 4x4 8x8 12x12 Distance (cm) FOV(cm)
  • 9. Innovation is the vital spark of all human change Radioguided Surgery: wanted Situation NO technological limitations: A complete system for radioguided surgery. Revolutionary integrated cancer detection equipment for ease use in / out the OR. GAMMACAMERA + POINTERS + PROBE + VERIFICATION SOFTWARE Real time vision in OR of tumours and related drainage + lymph nodes, with high sensibility and sensitivity (>75% than probes 1 ): variable FOV and collimator, acquisition time, comparative images IN VIVO / EX VIVO + node verification software . EVIDENCE BASED MEDICINE: Wide range of international publications
  • 10.
  • 11.
  • 12. Sentinella specifications : A B C Innovation is the vital spark of all human change
  • 13. Sentinella procedures : A B C Innovation is the vital spark of all human change
  • 14.
  • 15.
  • 16. Practical example 3: Sentinella in Prostate cancer Images from NKI-AvL / Dr. Renato Valdes Olmos Innovation is the vital spark of all human change
  • 17.
  • 18. Succesful experience in 4000 patients!

Notas del editor

  1. GI: gastrointestinal MI: minimal invasive
  2. GI: gastrointestinal MI: minimal invasive
  3. GI: gastrointestinal MI: minimal invasive
  4. GI: gastrointestinal MI: minimal invasive
  5. ROLL (RadioguideOccult LessionLocalization’ techniek voor niet palpabele leasies. Veel ervaring Clinica Barcelona / Dr Vidal en consorten. Toepassing T1 T2 tumoren en ductaal carcinoma in situ. Sentinel Node (SN) exclussion criteria in breast cancer: - Tumors > 3 cm - Previous chemiotheraphy and radiotheraphy - Previous surgery or lymphadenectomy - Multicentric and multifocal cancer - Pregnants Doel± controle snijranden – elimineren harpoon techniek! 2h after injection images in NMdept: SPECT/CT, LYmfescinitgrafie of Sentinella. 18-24h after injection: surgery with Sentinella.
  6. ROLL (RadioguideOccult LessionLocalization’ techniek voor niet palpabele leasies. Veel ervaring Clinica Barcelona / Dr Vidal en consorten. Toepassing T1 T2 tumoren en ductaal carcinoma in situ. Sentinel Node (SN) exclussion criteria in breast cancer: - Tumors > 3 cm - Previous chemiotheraphy and radiotheraphy - Previous surgery or lymphadenectomy - Multicentric and multifocal cancer - Pregnants Doel± controle snijranden – elimineren harpoon techniek! 2h after injection images in NMdept: SPECT/CT, LYmfescinitgrafie of Sentinella. 18-24h after injection: surgery with Sentinella.
  7. SPECT-CT in combinatie met REAL TIME INTRA OPERATIVE IMAGING: de ideale combinaie voor SN localisatie VOORDELEN: NAUWKEURIGE TUMOR STATUS - high prognostic value & significant TNM! MORE DETAILED ANATOMIC INFORMATION – KRITIEKE ORGANEN! VERBETERED LOCALISATIE EN DIEPTE BEPALING DETECTEREN VAN TWEE RADIONUCLIDES (Jodium / Gd ) VOOR OPTIMALE VERIFICATIE
  8. Controle hersendood aan de hand van perusie scan + voorbeeld in spanje