8. Plaque Morphology
Vs.
Plaque Activity
Why do we need to go beyond
morphological assessment of
plaques? Why do we need both?
The short answer is: because not all
plaques with similar morphology would
result in similar outcome.
9. SPIO
Super
Paramagnetic
Iron
Oxide
Colloidal coated particles of iron oxide, e.g.
dextran coated SPIO (Feridex I.V.)
13. Non-invasive MRI study of
atherosclerotic plaques using SPIO
(pre and post injection comparison)
may be a likely method for detection of
vulnerable plaques
Further studies particularly human
clinical trials are warranted
14. SPIO Clinical Trial:
- The first human clinical trial on
detection of carotid vulnerable
plaque using SPIO in patients
undergoing carotid
endartherectomy
Baseline
Scan
SPIO
Injection
1hr post-
injection
5days
Scan
Surgery