This study found that immune deficiency results in increased neointimal formation (thickening of the artery wall) after arterial injury in mice. Adoptive transfer of B cells from wild type mice to immune deficient Rag-1 KO mice inhibited neointimal formation in the Rag-1 KO mice after arterial injury, regardless of diet. The presence of immunoglobulins like IgM and IgG increased in the injured arteries of wild type mice and B cell reconstituted Rag-1 KO mice. This suggests that humoral aspects of the immune system mediated by B cells and immunoglobulins may play a role in inhibiting neointimal formation after arterial injury.