wound epidermis manacle gene shinguard gene mammalian liver axolotl salamander hydra morphallaxis epimorphosis regeneration dave henderson james farrell imprinting defects oca2 gene ube3a gene dr. harry angelman happy puppet syndrome chromosome 15 paternal disomy 15 puppet syndrome puppet 15q deletion upd as angelman syndrome trypsin srm university pbs pbmc karyotyping karyogram iscn hypotonic kcl harvesting gtg banding giemsa buffer genetic engineering cytogenetics culturing colchicine chromosome landmarks chromosome banding chromosome casting banding vmax km half-life time half-life enzyme deactivation kinetics thermal denaturation effect of ph on enzyme activity derivations substrate inhibition mixed inhibition non-competitive inhibition uncompetitive inhibition competitive inhibition inhibition reversible inhibition lb plot mm equation lineweaver-burk plot michaelis-menten enzyme kinetics hemoglobin beta-chain 6th amino acid hba2 hba hbf hbb gene autosomal recessive bone-marrow transplantation hydroxyurea augmentation therapy carbamazepine 14 q-arm chromosome 14 hepatocyte endoplasmic reticulum signalling jaundice copd chronic obstructive pulmonary disease elastin neutrophil elastase liver cirrhosis emphysema piz pis pimm serpina1 a1at aatd alpha-1 anti-trypsin deficiency alpha-1 anti-trypsin hbs sickle hemoglobin sca sickle cell anemia scd malaria genetics sickling sickle cell disease male reproductive system-associated diseases spermatogenesis male reproductive system
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