3. Dedicated to Histopathology
We provide our customer in histopathology
laboratories worldwide with reliable, high
quality products and support, while
pursuing continuous
improvement, customer
satisfaction, market leadership and a
positive employee work environment.
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4.
5. Sakura Core Values
Reliability
High Quality
Innovation
Customer Added Value
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9. Challenges in histopathology
Doing more with less
• Higher workload
• Turnaround time An inefficient lab
• Shortage of skilled staff Bottlenecks
• Cost pressure Waiting time
• Safety requirements
No standardisation
Multiple protocols
• Increased quality requirements
• Competitive working environment
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12. A Rapid, Efficient & Consistent
Quality Lab
Removing Bottlenecks & Standardisation Increase Same Day Diagnosis
Reducing waiting time and errors Create a continuous workflow Efficiency and Quality
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13. Remove bottlenecks and waiting time:
Increase same day diagnosis
Conventional Process
Waiting/ Batching
1x per day
10 - 12 hours
SMART Automation Process
Every 15 min
1 hour
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14. Average processing turnaround times:
Superior performance Xpress ® x Series
Overnight processing 20 hours
Multi-batch processing 8 hours
Continuous Processing 1,5 hours
* Average processing turnaround times include waiting time (Source: SMART Analysis Tool)
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15. Same Day Results:
Superior performance
Xpress® x Series
100% Before-Xpress
90%
Xpress
80%
70%
60%
50%
40%
30%
20%
10%
0%
Same day 2 days 3 days >3 days
80% same day results after using Xpress 1
1.) Rapid response, Molecular Friendly Surgical Pathology, Morales et al, Journal of American College of Surgeons, Vol. 207, September 2008
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19. Tissue-Tek® AutoWrite®
Cassette & Slide Printers
Efficiency
• Continuous printing supporting a LEAN workflow
• Ease of use with stacked cassettes
• Full flexibility of all tissue carriers
Speed
• Rapid printing, up to 900 cassettes/ 800 slides per
hour
• Convenient & rapid loading and unloading
Quality
• High quality 1D, 2D bar coding, graphics for easy and
reliable identification
• Compliant with SIX Sigma principles
• Connectable to LIMS & stand alone computer
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20. Accu-Edge®
Grossing Tool System
Quality
• Standardization of grossing leading to consistent
quality
• Successful LEAN and SIX Sigma implementation
• Quality Management demands standardization
• In-place Quality Management is required for laboratory
accreditation
Efficiency & speed
• Error reduction
• Less delays later in the process
• Overall process improvement
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22. Tissue-Tek ® Xpress® x Series
Efficiency
• Continuous efficient workflow/ Loading every 20 minutes:
• Workload leveling & Increased productivity
• Reduced levels of stress: Fewer human errors and rework Reduced cost
• Reagent volume reduction of more than 80%
Speed
• Standardized 1-hour processing/ Loading every 20 minutes
• Throughput of 120 cassettes/ to 960 cassettes in an 8-hour shift
• Unmatched same day diagnoses for all tissue types
• Reduced patient waiting time
Quality
• Excellent morphology and sharp nuclear details due to gentle microwave technology
• Standardized reproducible results: QC ready to use reagent kits
• Future ready: All results on one block including molecular studies
• Formalin- and xylene free processing
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23. Tissue-Tek ® Xpress® x Series
Tissue-Tek® Xpress® x120 Tissue-Tek® Xpress® x50
• Throughput of 120 cassettes per hour yielding to • Throughput of 50 cassettes per hour yielding to
a continuous throughput of up to 960 cassettes a continuous throughput of up to 400 cassettes
in an 8-hour shift in an 8-hour shift
• Load up to 40 cassettes every 15 minutes • Load up to 40 cassettes every 40 minutes
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24. How does it work?
SMART Automation and Intelligent Design
• Unique retort design with novel microwave technology and advanced robotics
• Reduced reagent carryover
• Intuitive menu screens and reporting tool
• Compatible with the AutoTEC® and Paraform®
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25. How does it work?
15 min 15 min 15 min 15 min
MW MW Heat Heat
Agitation agitation Vacuum Vacuum
Acetone Acetone
Isopropanol Isopropanol Paraffin Paraffin
Others Others
1-40
Cassettes
26. How does it work?
Complete Tissue Processing with only 2 reagents
• Low power microwave and reliable vacuum technology
• Circular microwave patterns
• Eliminate hot and cold spots
• Continuous throughput
• All specimens processed in the same program
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27. How does it work?
Novel System of Reagents for Distinct Detail
• Includes an exclusive paraffin formulation
• Preserves DNA, RNA, and proteins
• Eliminates the use of formalin and Xylene,
minimizing waste management costs
• Virtually eliminates chemical exposure due to closed system
• Features easy-to-use processing reagent sets
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29. Tissue-Tek® AutoTEC® & Paraform®
Efficiency
• Fully automated embedding
• A continuous efficient workflow
• Free up capacity for more value adding work
Speed
• Continuous loading and unloading
• 120 cassettes per hour/ Loading every 15 minutes
• Perfect fit with Tissue-Tek® Xpress® x Series®
• Same throughput: 120 cassettes per hour
Quality
• Eliminating orientation mistakes, mix up and tissue loss
• Usage of one magazine, identical paraffin wax
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32. Tissue-Tek® AutoTEC® & Paraform®
Principles
• Create a gentle workflow
• Create a higher productivity.
– 120 blocks an hour are embedded
• Blocks will have a consistent quality
• Orientation is preserved by the special
design of the Paraform® Cassettes
• Paraform Cassettes are compatible with
all existing methods, like
printing, processing and microtomy
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33. Operation of the Paraform® Cassette
Place the inner cassette
1 in the outer frame on a flat surface
Position the cassette underneath the 4 tabs
2
Place the tissue sample in the center of the cassette
3
Close the lid
4
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34. Operation of the AutoTEC®
Cassettes are placed in magazine
1
Magazines are loaded
2
Each cassette is picked from magazine one by one
3 Cassette type is identified
Cassettes are placed in pre-heated basemolds
4
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35. Operation of the AutoTEC®
Stager pushes down the cassette through the frame
1 A precise amount of paraffin is dispensed
Basemold cools to form a solid block
2 Block is removed from basemold and presented to
sensors
Paraffin block is placed in one of the output doors
3
Consistent quality blocks ready for microtomy
4
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37. Tissue-Tek® Prisma® & Film®
Efficiency
• True walk-away staining and coverslipping
• Automated transfer from stainer to coverslipper
• A continuous efficient workflow
• Unmatched capacity, up to 11 runs of 60 slides simultaneously
Speed
• Unmatched speed, 660 slides per hour
• Full flexibility in staining protocols and batch size with reagent
reservoirs of 160 mL, 260 mL and 680 mL
• Multiple programs at the same time (routine and specials)
Quality
• Long lasting protection with adhesive backed polymer film
• Air bubble detector guarantees bubble free coverslipping
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39. Hillerød hospital:
Not only figures but real life results
We are now delivering a better service to more patients
The workflow is steady and there are no batches to face
each morning, staff are no longer so stressed.
The increased automation, as well as other innovations
resulting from LEAN, have lead to a greatly improved
Hanne Bjørn, Senior Chief Biomedical workflow and processing time, and reduced standby time.
Laboratory Scientist, Hillerød
Hospital, Denmark
Our improvements have had a knock-on effect on the
cytology lab personnel who have also increased output
and become more patient focused.
Source: Clinical Lab Magazine
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40. Maastricht University Medical Centre:
Faster Diagnosis of Cancer
Now, diagnoses are made within two hours. Continuously.
Malignant tumours can be diagnosed within a few hours
without any concessions to quality.
New cassettes can be loaded every fifteen minutes on the
Xpress without unnecessary waiting.
Professor Axel zur Hausen, Chair of the
Pathology Department at Maastricht
University Medical Centre. It is an improvement that we no longer have big stacks of
specimen to process. In addition, it decreases the chance
of making mistakes
“A quick and reliable diagnosis implies that treatment can
be started sooner.
Source: Clinical Lab Magazine
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43. Be SMART
A continuous efficient workflow
Improved
Unmatched same day results
patient care
A consistent high quality
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Notas del editor
HigherworkloadMore ptn casesMore test per case, includingincreasingimportannce of MolecularDiagnosticsIncreasedqualityrequirements: reproducibility of results
Quote: By doing more of the same no new results can be expectedQuote: ‘’Your current safe boundries were once unknown frontiers.’’
There are four chambers in Xpress. 1 and 2 there are microwave and a agitation with airbobbles.2 and 3 heat and vacuum
