2. Mitosis is the process in which the
nucleus divides to form two new
nuclei.
It plays an important part
in the development of embryos, and it
is important for the growth and
development of our bodies as
well. Mitosis produces new cells, and
replaces cells that are old, lost or
damaged. In mitosis a cell divides to
form two identical daughter cells.
4. Cells may appear inactive during this
stage, but they are quite the opposite.
This is the longest period of the complete
cell cycle during which DNA replicatesDNA replicates,
the centrioles divide, and proteins are
actively produced.
CELL
MEMBRANENucleus
Cytoplasm
5. • Chromosomes are copied (doubles)
• Chromosomes appear as threadlike coils
(chromatin) at the start, but each chromosome
and its copy(sister chromosome) change to sister
chromatids at end of this phase
CELL
MEMBRANENucleus
Cytoplasm
7. During this first mitotic stage, the nucleolus
fades and chromatin condenses into
chromosomes. Each replicated chromosome
comprises two chromatids, both with the same
genetic information. Microtubules of the
cytoskeleton, responsible for cell shape,
motility and attachment to other cells during
interphase, disassemble. And the building
blocks of these microtubules are used to grow
the mitotic spindle from the region of the
centrosomes.
8. • Mitosis begins (cell begins to divide)
• Centrioles (or poles) appear and begin to
move to opposite end of the cell.
• Spindle fibers form between the poles.
Centrioles
Sister chromatids
Spindle fibers
10. In this stage the nuclear envelope breaks
down so there is no longer a recognizable
nucleus. Some mitotic spindle fibers elongate
from the centrosomes and attach to
kinetochores, protein bundles at the
centromere region on the chromosomes
where sister chromatids are joined. Other
spindle fibers elongate but instead of
attaching to chromosomes, overlap each
other at the cell center.
11. • Chromatids (or pairs of chromosomes) attach
to the spindle fibers.
• The chromosomes arrange at the centre.
Centrioles
Spindle fibers
Kinetochore
13. Spindle fibers shorten, the kinetochores
separate, and the chromatids (daughter
chromosomes) are pulled apart and begin
moving to the cell poles.
Centrioles
Spindle fibers
14. • Chromatids (or pairs of chromosomes)
separate and begin to move to opposite
ends of the cell.
Centrioles
Spindle fibers
16. The daughter chromosomes arrive at the
poles and the spindle fibers that have pulled
them apart disappear.
The spindle fibers not attached to
chromosomes begin breaking down until
only that portion of overlap is left. It is in this
region that a contractile ring cleaves the
cell into two daughter cells. Microtubules
then reorganize into a new cytoskeleton for
the return to interphase.
17. • Two new nuclei form.
• Chromosomes appear as chromatin (threads
rather than rods).
• Mitosis ends.
NucleiNuclei
Chromatin